KIF18A - kinesin family member 18A Gene

Homo sapiens

Also known as PPP1R99; MS-KIF18A

Gene ID: 81930 | Gene type: protein coding

About KIF18A

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:28,020,619-28,108,156 (from NCBI)

This gene has 4 transcripts (splice variants), 190 orthologues and 41 paralogues. Biased expression in testis (RPKM 7.1), bone marrow (RPKM 2.7) and 11 other tissues.

Summary

KIF18A is a member of the Kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]

KIF18A Products(1)

mRNA	Protein	Name
NM_031217.4	NP_112494.3	kinesin-like protein KIF18A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IPI IPI: Inferred from physical interaction	18680169	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	18680169	GOA
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	17346968	GOA
enables plus-end-directed microtubule motor activity	IDA IDA: Inferred from direct assay	17346968	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231748	GOA
enables tubulin-dependent ATPase activity	IDA IDA: Inferred from direct assay	17346968	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in microtubule depolymerization	IDA IDA: Inferred from direct assay	17346968	GOA
involved in mitotic metaphase chromosome alignment	IDA IDA: Inferred from direct assay	17346968	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	17006958	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17006958	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	17346968	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17006958	GOA
located in ruffle	IDA IDA: Inferred from direct assay	17006958	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF18A Protein Structure

Kinesin

0
200
400
600
800
898 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF18A

protein phosphatase 1, regulatory subunit 99

KIF18A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KIF18A	Q8NI77	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	23288039

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Asbestosis

Idiopathic Interstitial Pneumonitis - From Asbestos Exposure

Pulmonary Fibrosis - From Asbestos Exposure

Goldberg-Shprintzen Syndrome

Goldberg-Shprintzen Megacolon Syndrome	GOSHS
Megacolon-Microcephaly Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132840	Sovilnesib	Inhibitor	99.89%	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101770	BTB-1	Inhibitor	99.75%	Unkown
HY-153065	KIF18A-IN-6	Inhibitor	98.56%	Unkown
HY-144894	AM-5308	Inhibitor	99.26%	Unkown
HY-145034	KIF18A-IN-1	Inhibitor	98.39%	Unkown
HY-145803	KIF18A-IN-3	Inhibitor	99.30%	Unkown
HY-153066	KIF18A-IN-7	Inhibitor	98.09%	Unkown
HY-162110	AM-9022	Inhibitor	99.48%	Unkown
HY-145802	KIF18A-IN-2	Inhibitor	99.34%	Unkown
HY-145827	KIF18A-IN-4	Inhibitor	/	Unkown
HY-158683	KIF18A-IN-11	Inhibitor	/	Unkown
HY-158757	KIF18A-IN-12	Inhibitor	/	Unkown
HY-162110A	(S)-AM-9022	Control	99.88%	Unkown
HY-162531	KIF18A-IN-9	Inhibitor	/	Unkown
HY-162532	KIF18A-IN-10	Inhibitor	/	Unkown
HY-162667	EX05	Inhibitor	/	Unkown
HY-162937	KIF18A-IN-13	Inhibitor	/	Unkown
HY-164978	KIF18A-IN-14	Inhibitor	/	Unkown
HY-164979	KIF18A-IN-15	Inhibitor	/	Unkown
HY-164980	KIF18A-IN-16	Inhibitor	/	Unkown
HY-RS07267	KIF18A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KIF18A	RGD	RGD:1561740
Felis catus	KIF18A	VGNC	VGNC:63107
Macaca mulatta	KIF18A	VGNC	VGNC:73944
Bos taurus	KIF18A	VGNC	VGNC:30587
Canis familiaris	KIF18A	VGNC	VGNC:42387
Mus musculus	KIF18A	MGD	MGI:2446977
Others	KIF18A	NCBI

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