NEK2 - NIMA related kinase 2 Gene

Homo sapiens

Also known as NLK1; RP67; NEK2A; HsPK21; PPP1R111

Gene ID: 4751 | Gene type: protein coding

About NEK2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,658,256-211,675,621 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in testis (RPKM 28.1), bone marrow (RPKM 3.8) and 6 other tissues.

Summary

This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

NEK2 Products(3)

mRNA	Protein	Name
NM_001204182.2	NP_001191111.1	serine/threonine-protein kinase Nek2 isoform 3
NM_001204183.2	NP_001191112.1	serine/threonine-protein kinase Nek2 isoform 2
NM_002497.4	NP_002488.1	serine/threonine-protein kinase Nek2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647649	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	10880350	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	24554434	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10880350	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome separation	IDA IDA: Inferred from direct assay	18086858	GOA
involved in chromosome segregation	IDA IDA: Inferred from direct assay	14978040	GOA
involved in negative regulation of centriole-centriole cohesion	IMP IMP: Inferred from mutant phenotype	24554434	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	17626005	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	10880350	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	21076410	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24554434	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	18297113	GOA
involved in regulation of mitotic centrosome separation	IMP IMP: Inferred from mutant phenotype	26220856	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	17621308	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	14978040	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	10880350	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK2 Protein Structure

Pkinase

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Nek2

NIMA (never in mitosis gene a)-related kinase 2

NEK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEK2	P51955	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	23288039
Intra	NEK2	P51955	KIF24	Homo sapiens	Q5T7B8	IF	26290419
Intra	NEK2	P51955	KIF24	Homo sapiens	Q5T7B8	Protein Kinase Assay	26290419
Intra	NEK2	P51955	MCC	Homo sapiens	P23508	Y2H	21900206
Intra	NEK2	P51955	PPP1CC	Homo sapiens	P36873-1	Far-WB	24116158
Intra	NEK2	P51955	PPP1CC	Homo sapiens	P36873-1	Y2H	21382349
Intra	NEK2	P51955	NEK11	Homo sapiens	Q8NG66	Pull Down	15161910
Intra	NEK2	P51955	CDC27	Homo sapiens	P30260	Anti Bait CoIP	16648845
Cross	NEK2	P51955	MGC80529	Crosspus laevis	Q6GQ04	Anti Bait CoIP	16648845

Cross: Cross-species interaction Intra: Intraspecies interaction

NEK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82165	NEK2 Antibody (YA1910)	WB	Human

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 67

RP67	Retinitis Pigmentosa, Type 67

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-120356A	T-1101 tosylate	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16660	INH1	Inhibitor	99.85%	Unkown
HY-117154	INH154		99.89%	Unkown
HY-101029	MBM-55	Inhibitor	99.94%	Unkown
HY-116423	JH295		98.99%	Unkown
HY-100541	INH6	Inhibitor	99.53%	Unkown
HY-B0790	TAI-1	Inhibitor	98.02%	Unkown
HY-101030A	MBM-17S	Inhibitor	/	Unkown
HY-137046	Nek2-IN-4		/	Unkown
HY-156437	NBI-961	Inhibitor	99.73%	Unkown
HY-116423A	JH295 hydrate		≥99.0%	Unkown
HY-153749	Nek2/Hec1-IN-2		≥98.0%	Unkown
HY-101029A	MBM-55S	Inhibitor	/	Unkown
HY-101030	MBM-17	Inhibitor	/	Unkown
HY-150046	Nek2-IN-6		/	Unkown
HY-120356	T-1101	Inhibitor	/	Unkown
HY-120330	Nek2-IN-5		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NEK2	VGNC	VGNC:75308
Mus musculus	NEK2	MGD	MGI:109359
Canis familiaris	NEK2	VGNC	VGNC:43731
Bos taurus	NEK2	VGNC	VGNC:31993
Felis catus	NEK2	VGNC	VGNC:68456
Rattus norvegicus	NEK2	RGD	RGD:619792
Others	NEK2	NCBI

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