CDC20 - cell division cycle 20 Gene

Homo sapiens

Also known as CDC20A; p55CDC; bA276H19.3

Gene ID: 991 | Gene type: protein coding

About CDC20

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,358,981-43,363,203 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues and 2 paralogues. Biased expression in testis (RPKM 26.5), bone marrow (RPKM 19.7) and 12 other tissues.

Summary

CDC20 appears to act as a regulatory protein interacting with several Other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

CDC20 Products(1)

mRNA	Protein	Name
NM_001255.3	NP_001246.2	cell division cycle protein 20 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables anaphase-promoting complex binding	IDA IDA: Inferred from direct assay	14743218	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10700282	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	27030811	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	17443180	GOA
involved in metaphase/anaphase transition of meiosis I	IMP IMP: Inferred from mutant phenotype	32666501	GOA
involved in positive regulation of mitotic metaphase/anaphase transition	IDA IDA: Inferred from direct assay	9637688	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11459826	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	11459825	GOA
part of mitotic checkpoint complex	IPI IPI: Inferred from physical interaction	27509861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC20 Protein Structure

WD40

0
100
200
300
400
499 a.a.

Protein Preferred Names

Protein Names

cell division cycle protein 20 homolog

CDC20 cell division cycle 20 homolog

CDC20 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDC20	Q12834	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	25383541
Intra	CDC20	Q12834	ANAPC4	Homo sapiens	Q9UJX5	TAP	20360068
Intra	CDC20	Q12834	ANAPC4	Homo sapiens	Q9UJX5	Anti Tag CoIP	25383541
Intra	CDC20	Q12834	RASSF1	Homo sapiens	Q9NS23-2	CoIP	14743218
Cross	CDC20	Q12834	Axin2	Mus musculus	O88566	Anti Tag CoIP	22322943
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	15182668
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	21407176
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	22340593
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	24581499
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	37926298
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Pull Down	18022367
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	25383541
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	TAP	20360068
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	33961781
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	20212161
Intra	CDC20	Q12834	MAD2L1	Homo sapiens	Q13257	Pull Down	17443186
Intra	CDC20	Q12834	CDC27	Homo sapiens	P30260	TAP	20360068
Intra	CDC20	Q12834	CDC27	Homo sapiens	P30260	Anti Bait CoIP	17443186
Intra	CDC20	Q12834	CDC27	Homo sapiens	P30260	Anti Bait CoIP	24781523
Intra	CDC20	Q12834	CDC27	Homo sapiens	P30260	Anti Tag CoIP	22014574

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome	MVA1
Mosaic Variegated Aneuploidy Syndrome, Type 1	Mosaic Variegated Aneuploidy Syndrome
Congenital Chromosomal Disease

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110287	Apcin	Inhibitor	99.71%	Unkown
HY-130257	CP5V	Inhibitor	99.31%	Unkown
HY-100341	M2I-1	Inhibitor	≥98.0%	Unkown
HY-116006	Bis-PEG5-acid		95.77%	Unkown
HY-130841	Apcin-A	Inhibitor	≥98.0%	Unkown
HY-13255	TAME	Inhibitor	99.51%	Unkown
HY-131959	(S,R,S)-AHPC-PEG5-Boc		95.29%	Unkown
HY-13255A	TAME hydrochloride	Inhibitor	98.31%	Unkown
HY-161257	CDC20-IN-1	Inducer	/	Unkown
HY-RS02288	CDC20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02289	CDC20B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W614725	Apcin-A monohydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC20	VGNC	VGNC:107502
Rattus norvegicus	CDC20	RGD	RGD:620477
Mus musculus	CDC20	MGD	MGI:1859866
Bos taurus	CDC20	VGNC	VGNC:27060
Canis familiaris	CDC20	VGNC	VGNC:38987

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