SLC39A2 - solute carrier family 39 member 2 Gene

Homo sapiens

Also known as 6A1; ZIP2; ETI-1; ZIP-2

Gene ID: 29986 | Gene type: protein coding

About SLC39A2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,999,293-21,001,871 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 2 paralogues. Biased expression in skin (RPKM 12.0), esophagus (RPKM 8.3) and 3 other tissues.

Summary

This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]

SLC39A2 Products(2)

mRNA	Protein	Name
NM_001256588.2	NP_001243517.1	zinc transporter ZIP2 isoform b
NM_014579.4	NP_055394.2	zinc transporter ZIP2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metal ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	29791142	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	29791142	GOA
enables zinc ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20148757	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cadmium ion transmembrane transport	IDA IDA: Inferred from direct assay	29791142	GOA
involved in zinc ion transmembrane transport	IDA IDA: Inferred from direct assay	29791142	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20148757	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A2 Protein Structure

Zip

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

zinc transporter ZIP2

ZRT/IRT-like protein 2

SLC39A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC39A2	Q9NP94	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	TRHR	Homo sapiens	P34981	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	TRHR	Homo sapiens	P34981	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	SLC39A2	Q9NP94	CNR2	Homo sapiens	P34972	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	CNR2	Homo sapiens	P34972	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	SLC39A2	Q9NP94	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	LY6G6C	Homo sapiens	O95867	Y2H Prey Pooling	32296183
Intra	SLC39A2	Q9NP94	LY6G6C	Homo sapiens	O95867	Y2H Array	32296183
Intra	SLC39A2	Q9NP94	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Carotid Artery Disease

Carotid Artery Diseases

Disorder Of Carotid Artery

Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica	AEZ
Enteropathica	Brandt Syndrome
Ae	Acrodermatitis Enteropathica Zinc Deficiency Type
Danbolt-Cross Syndrome	Acrodermatitis Enteropathica, Zinc Deficiency Type
Inherited Zinc Deficiency	Acrodermatitis Enteropathica, Zinc Deficiency
Danbolt-Closs Syndrome	Primary Zinc Malabsorption Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13234	SLC39A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC39A2	MGD	MGI:2684326
Rattus norvegicus	SLC39A2	RGD	RGD:1306291
Bos taurus	SLC39A2	VGNC	VGNC:34863
Canis familiaris	SLC39A2	VGNC	VGNC:46403
Felis catus	SLC39A2	VGNC	VGNC:65359

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