ZBTB48 - zinc finger and BTB domain containing 48 Gene

Homo sapiens

Also known as HKR3; TZAP; ZNF855; pp9964

Gene ID: 3104 | Gene type: protein coding

About ZBTB48

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,579,994-6,589,280 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 7.4) and 25 other tissues.

Summary

Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription, DNA-templated and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB48 Products(3)

mRNA	Protein	Name
NM_001278647.2	NP_001265576.1	telomere zinc finger-associated protein
NM_001278648.2	NP_001265577.1	telomere zinc finger-associated protein
NM_005341.4	NP_005332.1	telomere zinc finger-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded telomeric DNA binding	IDA IDA: Inferred from direct assay	28082411	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	28500257	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28500257	GOA
involved in telomere maintenance via telomere lengthening	IMP IMP: Inferred from mutant phenotype	28082411	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	28082411	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB48 Protein Structure

BTB

zf-H2C2_2

zf-C2H2_4

zf-H2C2_2

0
200
400
600
688 a.a.

Protein Preferred Names

Protein Names

telomere zinc finger-associated protein

GLI-Kruppel family member HKR3

ZBTB48 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZBTB48	P10074	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	ZBTB48	P10074	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	ZBTB48	P10074	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	ZBTB48	P10074	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	ZBTB48	P10074	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	ZBTB48	P10074	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	ZBTB48	P10074	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZNF317	Homo sapiens	Q96PQ6	Y2H Array	32296183
Intra	ZBTB48	P10074	ZNF317	Homo sapiens	Q96PQ6	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZNF317	Homo sapiens	Q96PQ6	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	ZBTB48	P10074	MCC	Homo sapiens	P23508	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	ZBTB48	P10074	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZBTB9	Homo sapiens	Q96C00	Y2H Array	32296183
Intra	ZBTB48	P10074	WDR5	Homo sapiens	P61964	Validated Y2H	32296183
Intra	ZBTB48	P10074	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Prey Pooling	25416956
Intra	ZBTB48	P10074	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Array	25416956
Intra	ZBTB48	P10074	GPATCH2L	Homo sapiens	Q9NWQ4	Validated Y2H	25416956
Intra	ZBTB48	P10074	ZBTB6	Homo sapiens	Q15916	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	ZBTB6	Homo sapiens	Q15916	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZBTB6	Homo sapiens	Q15916	Y2H Array	32296183
Intra	ZBTB48	P10074	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	TRIM41	Homo sapiens	Q8WV44	Y2H Array	32296183
Intra	ZBTB48	P10074	TRIM41	Homo sapiens	Q8WV44	Y2H	21516116
Intra	ZBTB48	P10074	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	ZBTB48	P10074	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	ZBTB48	P10074	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	ZBTB48	P10074	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	ZBTB48	P10074	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	ZBTB48	P10074	L3MBTL2	Homo sapiens	Q969R5	Validated Y2H	32296183
Intra	ZBTB48	P10074	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	ZBTB48	P10074	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	ZBTB48	P10074	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	ZBTB48	P10074	ZBTB8A	Homo sapiens	Q96BR9	Y2H Pooling	16189514
Intra	ZBTB48	P10074	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	25416956
Intra	ZBTB48	P10074	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	ZBTB48	P10074	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	ZBTB48	P10074	NME7	Homo sapiens	Q9Y5B8	Y2H Array	25416956
Intra	ZBTB48	P10074	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	25416956
Intra	ZBTB48	P10074	ZBTB48	Homo sapiens	P10074	Y2H Array	32296183
Intra	ZBTB48	P10074	ZBTB48	Homo sapiens	P10074	Validated Y2H	32296183
Intra	ZBTB48	P10074	ZBTB48	Homo sapiens	P10074	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	ZBTB48	Homo sapiens	P10074	Y2H Array	25416956
Intra	ZBTB48	P10074	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ZBTB48	P10074	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	ZBTB48	P10074	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ZBTB48	P10074	TSPYL2	Homo sapiens	Q9H2G4	Y2H Prey Pooling	32296183
Intra	ZBTB48	P10074	TSPYL2	Homo sapiens	Q9H2G4	Validated Y2H	32296183
Intra	ZBTB48	P10074	TSPYL2	Homo sapiens	Q9H2G4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15978	ZBTB48 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZBTB48	VGNC	VGNC:79959
Rattus norvegicus	ZBTB48	RGD	RGD:1311581
Bos taurus	ZBTB48	VGNC	VGNC:37085
Canis familiaris	ZBTB48	VGNC	VGNC:48540
Felis catus	ZBTB48	VGNC	VGNC:80407
Mus musculus	ZBTB48	MGD	MGI:2140248
Others	ZBTB48	NCBI

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