Gpr35 - G protein-coupled receptor 35 Gene

Rattus norvegicus

Gene ID: 367315 | Gene type: protein coding

About Gpr35

Primary_assembly 9: 93,527,127-93,539,299 forward strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 228 orthologues, 14 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 9.6), Thymus (RPKM 4.6) and 6 other tissues.

Summary

Predicted to enable C-X-C Chemokine Receptor activity. Involved in negative regulation of neuronal action potential. Located in plasma membrane. Orthologous to human GPR35 (G protein-coupled receptor 35). [provided by Alliance of Genome Resources, Apr 2022]

Gpr35 Products(1)

mRNA	Protein	Name
NM_001037359.2	NP_001032436.2	G-protein coupled receptor 35

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	17996730	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	17940199	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16754668	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr35 Protein Structure

7tm_GPCRs

0
100
200
306 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 35

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100806	Kynurenic acid	Agonist	99.21%	Phase 1
HY-107512	Kynurenic acid sodium	Agonist	99.79%	Phase 1
HY-100806R	Kynurenic acid (Standard)	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107537	CID 2745687	Agonist	98.07%	Unkown
HY-W008613	Pamoic acid	Agonist	98.15%	Unkown
HY-B1816	Zaprinast	Agonist	99.95%	Unkown
HY-100806S	Kynurenic acid-d5	Agonist	98.35%	Unkown
HY-107536	ML 145		97.04%	Unkown
HY-W010907	Pamoic acid disodium	Agonist	99.86%	Unkown
HY-134801	CID1231538		99.74%	Unkown
HY-101033	GPR35 agonist 1		99.22%	Unkown
HY-W018158	DHICA	Activator	≥97.0%	Unkown
HY-15705	GPR35 agonist 2	Agonist	98.84%	Unkown
HY-149190	GPR35 agonist 5	Agonist	98.86%	Unkown
HY-107538	YE120	Agonist	99.80%	Unkown
HY-107539	GPR35 agonist 4	Agonist	≥99.0%	Unkown
HY-169302	GPR35 activator-1	Activator	/	Unkown
HY-169304	Gpr35 modulator 3	Modulator	/	Unkown
HY-169301	Gpr35 modulator 1	Modulator	/	Unkown
HY-169303	Gpr35 modulator 2	Modulator	/	Unkown
HY-106481	Bufrolin	Agonist	/	Unkown
HY-131728	GPR35 agonist 3	Agonist	98.32%	Unkown
HY-101958	Tyrphostin 25	Agonist	99.00%	Unkown
HY-167706	Diethyl-Lodoxamide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpr35	NCBI	NCBI:2859

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