2. Gene
  3. ITGB5 - integrin subunit beta 5 Gene

ITGB5 - integrin subunit beta 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 3693 | Gene type: protein coding

About ITGB5

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:124,761,948-124,901,418 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 40.4), gall bladder (RPKM 34.0) and 24 other tissues.

Summary

This gene encodes a beta subunit of Integrin, which can combine with different alpha chains to form a variety of Integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 Integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

ITGB5 Products(4)

mRNA Protein Name
NM_001354764.2 NP_001341693.1 integrin beta-5 isoform b
NM_001354765.1 NP_001341694.1 integrin beta-5 isoform b
NM_001354766.2 NP_001341695.1 integrin beta-5 isoform c
NM_002213.5 NP_002204.2 integrin beta-5 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
1694173 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
26934001 GOA
involved in cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in endodermal cell differentiation IEP
IEP: Inferred from expression pattern
23154389 GOA
involved in epithelial cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
7525578 GOA
part of integrin alphav-beta5 complex IDA
IDA: Inferred from direct assay
25063885 GOA
part of integrin alphav-beta5 complex IPI
IPI: Inferred from physical interaction
1694173 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB5 Protein Structure

Integrin_beta

Integrin_beta: Integrin beta chain VWA domain (35 - 463)

Integrin_B_tail

Integrin_B_tail: Integrin beta tail domain (635 - 719)

Integrin_b_cyt

Integrin_b_cyt: Integrin beta cytoplasmic domain (743 - 789)

  • 0
  • 200
  • 400
  • 600
  • 799 a.a.
Protein Preferred Names Protein Names

integrin beta-5

testis secretory sperm-binding protein Li 217p

ITGB5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ITGB5 P18084 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
ITGB5 P18084 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
ITGB5 P18084 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRTAP10-9 Homo sapiens P60411
Validated Y2H
32296183
Intra
ITGB5 P18084 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
ITGB5 P18084 KRTAP10-7 Homo sapiens P60409
Validated Y2H
32296183
Intra
ITGB5 P18084 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
ITGB5 P18084 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
ITGB5 P18084 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Cross
ITGB5 P18084 Myo7a Mus musculus P97479
Pull Down
24997346
Intra
ITGB5 P18084 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
ITGB5 P18084 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
ITGB5 P18084 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
ITGB5 P18084 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
ITGB5 P18084 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
ITGB5 P18084 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra
ITGB5 P18084 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
ITGB5 P18084 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
ITGB5 P18084 ANGPTL4 Homo sapiens Q9BY76
PLA
21397862
Intra
ITGB5 P18084 ANGPTL4 Homo sapiens Q9BY76
SPR
21397862
Intra
ITGB5 P18084 MYO10 Homo sapiens Q9HD67
Pull Down
21642953
Intra
ITGB5 P18084 MYO10 Homo sapiens Q9HD67
Competition Binding
21642953
Intra
ITGB5 P18084 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ITGB5 P18084 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ITGB5 P18084 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
ITGB5 P18084 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
ITGB5 P18084 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
ITGB5 P18084 FRMD5 Homo sapiens Q7Z6J6
Pull Down
25448675
Intra
ITGB5 P18084 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
ITGB5 P18084 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra
ITGB5 P18084 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra
ITGB5 P18084 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
ITGB5 P18084 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra
ITGB5 P18084 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
ITGB5 P18084 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
ITGB5 P18084 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra
ITGB5 P18084 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
ITGB5 P18084 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
ITGB5 P18084 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ITGB5 Proteins

Cat. No. Product Name Accession Purity
HY-P77720 Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi) P06756-1 (F31-V992)&P18084 (G24-N719) ≥95%

ITGB5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83363 Integrin beta 5 Antibody (YA3108) WB Human, Hamster, Rat

Related Diseases

Diseases Alias
Villous Adenocarcinoma
Osteopetrosis, Autosomal Dominant 2

OPTA2

Autosomal Dominant Osteopetrosis 2

Osteopetrosis Autosomal Dominant Type 2

Osteopetrosis, Autosomal Dominant, Type Ii

Albers-Schonberg Osteopetrosis

Autosomal Dominant Albers-Schonberg Disease

Osteopetrosis

Marble Bones, Autosomal Dominant

Osteosclerosis Fragilis Generalisata

Albers-Schonberg Disease, Autosomal Dominant

Autosomal Dominant Osteopetrosis Type Ii

Albers-Schönberg Osteopetrosis

Autosomal Dominant Osteopetrosis Type 2

Marble Disease Autosomal Dominant

Osteopetrosis, Autosomal Dominant, Type 2
Luminal Breast Carcinoma A

Breast Tumor Luminal

Luminal A Breast Carcinoma

Luminal Breast Cancer
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06969 ITGB5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ITGB5 VGNC VGNC:73788
Canis familiaris ITGB5 VGNC VGNC:42140
Felis catus ITGB5 VGNC VGNC:67854
Bos taurus ITGB5 VGNC VGNC:30330
Rattus norvegicus ITGB5 RGD RGD:628869
Mus musculus ITGB5 MGD MGI:96614
Others ITGB5 NCBI