2. Gene
  3. ITGB5 - integrin subunit beta 5 Gene

ITGB5 - integrin subunit beta 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 3693 | Gene type: protein coding

About ITGB5

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:124,761,948-124,901,418 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 40.4), gall bladder (RPKM 34.0) and 24 other tissues.

Summary

This gene encodes a beta subunit of Integrin, which can combine with different alpha chains to form a variety of Integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 Integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

ITGB5 Products(4)

mRNA Protein Name
NM_001354764.2 NP_001341693.1 integrin beta-5 isoform b
NM_001354765.1 NP_001341694.1 integrin beta-5 isoform b
NM_001354766.2 NP_001341695.1 integrin beta-5 isoform c
NM_002213.5 NP_002204.2 integrin beta-5 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
1694173 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
26934001 GOA
involved in cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in endodermal cell differentiation IEP
IEP: Inferred from expression pattern
23154389 GOA
involved in epithelial cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
7525578 GOA
part of integrin alphav-beta5 complex IDA
IDA: Inferred from direct assay
25063885 GOA
part of integrin alphav-beta5 complex IPI
IPI: Inferred from physical interaction
1694173 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB5 Protein Structure

Integrin_beta

Integrin_beta: Integrin beta chain VWA domain (35 - 463)

Integrin_B_tail

Integrin_B_tail: Integrin beta tail domain (635 - 719)

Integrin_b_cyt

Integrin_b_cyt: Integrin beta cytoplasmic domain (743 - 789)

  • 0
  • 200
  • 400
  • 600
  • 799 a.a.
Protein Preferred Names Protein Names

integrin beta-5

testis secretory sperm-binding protein Li 217p

Recombinant ITGB5 Proteins

Cat. No. Product Name Accession Purity
HY-P77720 Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi) P06756-1 (F31-V992)&P18084 (G24-N719) ≥95%

Related Diseases

Diseases Alias
Villous Adenocarcinoma
Osteopetrosis, Autosomal Dominant 2

OPTA2

Autosomal Dominant Osteopetrosis 2

Osteopetrosis Autosomal Dominant Type 2

Osteopetrosis, Autosomal Dominant, Type Ii

Albers-Schonberg Osteopetrosis

Autosomal Dominant Albers-Schonberg Disease

Osteopetrosis

Marble Bones, Autosomal Dominant

Osteosclerosis Fragilis Generalisata

Albers-Schonberg Disease, Autosomal Dominant

Autosomal Dominant Osteopetrosis Type Ii

Albers-Schönberg Osteopetrosis

Autosomal Dominant Osteopetrosis Type 2

Marble Disease Autosomal Dominant

Osteopetrosis, Autosomal Dominant, Type 2
Luminal Breast Carcinoma A

Breast Tumor Luminal

Luminal A Breast Carcinoma

Luminal Breast Cancer
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06969 ITGB5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ITGB5 VGNC VGNC:73788
Canis familiaris ITGB5 VGNC VGNC:42140
Felis catus ITGB5 VGNC VGNC:67854
Bos taurus ITGB5 VGNC VGNC:30330
Rattus norvegicus ITGB5 RGD RGD:628869
Mus musculus ITGB5 MGD MGI:96614
Others ITGB5 NCBI