LECT2 - leukocyte cell derived chemotaxin 2 Gene

Homo sapiens

Also known as chm2; chm-II

Gene ID: 3950 | Gene type: protein coding

About LECT2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,946,904-135,954,983 (from NCBI)

This gene has 5 transcripts (splice variants) and 213 orthologues. Restricted expression toward liver (RPKM 110.6).

Summary

This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

LECT2 Products(1)

mRNA	Protein	Name
NM_002302.3	NP_002293.2	leukocyte cell-derived chemotaxin-2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23352894	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27334921	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LECT2 Protein Structure

Peptidase_M23

0
100
151 a.a.

Protein Preferred Names

Protein Names

leukocyte cell-derived chemotaxin-2

chondromodulin-II

LECT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LECT2	O14960	WDR26	Homo sapiens	Q9H7D7	Anti Tag CoIP	33961781
Intra	LECT2	O14960	ITIH2	Homo sapiens	P19823	Anti Tag CoIP	33961781
Intra	LECT2	O14960	LRP2	Homo sapiens	P98164	Anti Tag CoIP	33961781
Intra	LECT2	O14960	GID4	Homo sapiens	Q8IVV7	Anti Tag CoIP	33961781
Intra	LECT2	O14960	LECT2	Homo sapiens	O14960	Comigration in Gel	23352894
Intra	LECT2	O14960	RNF123	Homo sapiens	Q5XPI4	Anti Tag CoIP	33961781
Intra	LECT2	O14960	GID8	Homo sapiens	Q9NWU2	Anti Tag CoIP	33961781
Intra	LECT2	O14960	THUMPD3	Homo sapiens	Q9BV44	Anti Tag CoIP	33961781
Intra	LECT2	O14960	UBAC1	Homo sapiens	Q9BSL1	Anti Tag CoIP	33961781
Intra	LECT2	O14960	RANBP10	Homo sapiens	Q6VN20	Anti Tag CoIP	33961781
Intra	LECT2	O14960	ARMC8	Homo sapiens	Q8IUR7	Anti Tag CoIP	33961781
Intra	LECT2	O14960	NPM1	Homo sapiens	P06748	Crosslink	30021884
Intra	LECT2	O14960	RANBP9	Homo sapiens	Q96S59	Anti Tag CoIP	33961781
Intra	LECT2	O14960	CSPG4	Homo sapiens	Q6UVK1	Anti Tag CoIP	33961781
Intra	LECT2	O14960	AKAP11	Homo sapiens	Q9UKA4	Anti Tag CoIP	33961781
Intra	LECT2	O14960	KIAA0232	Homo sapiens	Q92628	Anti Tag CoIP	33961781
Intra	LECT2	O14960	FREM2	Homo sapiens	Q5SZK8	Anti Tag CoIP	33961781
Intra	LECT2	O14960	MKLN1	Homo sapiens	Q9UL63	Anti Tag CoIP	33961781
Intra	LECT2	O14960	RSL1D1	Homo sapiens	O76021	Crosslink	30021884
Intra	LECT2	O14960	RMND5A	Homo sapiens	Q9H871	Anti Tag CoIP	33961781
Intra	LECT2	O14960	MAEA	Homo sapiens	Q7L5Y9	Anti Tag CoIP	33961781
Intra	LECT2	O14960	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Immunoglobulin Heavy Chain Amyloidosis

Ah Amyloidosis	Heavy Chain Amyloidosis
Amyloidosis Derived From Immunoglobulin Heavy Chain	Ig Heavy-Chain-Associated Amyloidosis

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Immunoglobulin Light Chain Amyloidosis

Al Amyloidosis	Primary Amyloidosis
Primary Systemic Amyloidosis	Light Chain Amyloidosis
Amyloidosis Al	Amyloidosis Primary Systemic
Primary Al Amyloidosis	Primary Systemic Al Amyloidosis
Systemic Al Amyloidsis	Systemic Al Amyloidosis
Light-Chain Amyloidosis	Alys Amyloidosis
Familial Amyloid Nephropathy Due To Lysozyme Variant	Familial Renal Amyloidosis Due To Lysozyme Variant
Hereditary Amyloid Nephropathy Due To Lysozyme Variant	Hereditary Renal Amyloidosis Due To Lysozyme Variant
Lysozyme Amyloidosis	Amyloidosis Primary
Immunoglobulin Deposition Disease	Immunoglobulinic Amyloidosis
Amyloid Al

Amyloidosis, Finnish Type

Finnish Type Amyloidosis	Meretoja Syndrome
Amyloidosis V	Amyloidosis, Meretoja Type
Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy	Lattice Corneal Dystrophy Type Ii
Familial Amyloidosis, Finnish Type	Familial Amyloid Polyneuropathy Type Iv
Amyloidosis Due To Mutant Gelsolin	Agel Amyloidosis
Gelsolin Amyloidosis	Hereditary Gelsolin Amyloidosis
Lattice Corneal Dystrophy Type Ii Finnish	Gelsolin-Related Amyloidosis
Kymenlaakso Syndrome	Lattice Corneal Dystrophy, Gelsolin Type
Hereditary Amyloidosis, Finnish Type	Lattice Corneal Dystrophy Type 2
Amyloidosis 5	AMYL5
Agel	Familial Amyloidosis Finnish Type
Meretoja Type Amyloidosis	Type Iv Familial Amyloid Polyneuropathy
Familial Amyloid Polyneuropathy, Type V	Familial Amyloid Polyneuropathy, Type Iv

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07583	LECT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LECT2	VGNC	VGNC:30832
Macaca mulatta	LECT2	VGNC	VGNC:74250
Canis familiaris	LECT2	VGNC	VGNC:42629
Mus musculus	LECT2	MGD	MGI:1278342
Rattus norvegicus	LECT2	RGD	RGD:1305404
Felis catus	LECT2	VGNC	VGNC:68033

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