2. Gene
  3. LTBR - lymphotoxin beta receptor Gene

LTBR - lymphotoxin beta receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III

Gene ID: 4055 | Gene type: protein coding

About LTBR

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,375,160-6,391,566 (from NCBI)

This gene has 15 transcripts (splice variants), 546 orthologues and 21 paralogues. Ubiquitous expression in prostate (RPKM 23.4), placenta (RPKM 23.0) and 25 other tissues.

Summary

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and Other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

LTBR Products(12)

mRNA Protein Name
NM_001270987.2 NP_001257916.1 tumor necrosis factor receptor superfamily member 3 isoform 2
NM_001414303.1 NP_001401232.1 tumor necrosis factor receptor superfamily member 3 isoform 3 precursor
NM_001414304.1 NP_001401233.1 tumor necrosis factor receptor superfamily member 3 isoform 4 precursor
NM_001414305.1 NP_001401234.1 tumor necrosis factor receptor superfamily member 3 isoform 5 precursor
NM_001414306.1 NP_001401235.1 tumor necrosis factor receptor superfamily member 3 isoform 6 precursor
NM_001414307.1 NP_001401236.1 tumor necrosis factor receptor superfamily member 3 isoform 7 precursor
NM_001414308.1 NP_001401237.1 tumor necrosis factor receptor superfamily member 3 isoform 8 precursor
NM_001414309.1 NP_001401238.1 tumor necrosis factor receptor superfamily member 3 isoform 9
NM_001414310.1 NP_001401239.1 tumor necrosis factor receptor superfamily member 3 isoform 10 precursor
NM_001414311.1 NP_001401240.1 tumor necrosis factor receptor superfamily member 3 isoform 11 precursor
NM_001414312.1 NP_001401241.1 tumor necrosis factor receptor superfamily member 3 isoform 12 precursor
NM_002342.3 NP_002333.1 tumor necrosis factor receptor superfamily member 3 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20732415 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8995654 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
20732415 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: Inferred from expression pattern
12761501 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
20732415 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTBR Protein Structure

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (43 - 80)

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (83 - 124)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 435 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 3

lymphotoxin B receptor

LTBR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LTBR P36941 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
Intra
LTBR P36941 ZMYND11 Homo sapiens Q15326
Y2H
20732415
Intra
LTBR P36941 ZMYND11 Homo sapiens Q15326
Anti Tag CoIP
20732415
Intra
LTBR P36941 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra
LTBR P36941 ns7b_sars2 SARS-CoV-2 P0DTD8
Y2H Array
36217030
Intra
LTBR P36941 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
20732415
Intra
LTBR P36941 BIRC2 Homo sapiens Q13490
Anti Tag CoIP
33961781
Intra
LTBR P36941 BIRC2 Homo sapiens Q13490
Anti Tag CoIP
28514442
Intra
LTBR P36941 TRAF3 Homo sapiens Q13114
Anti Tag CoIP
33961781
Intra
LTBR P36941 BLZF1 Homo sapiens Q9H2G9
Anti Tag CoIP
28514442
Intra
LTBR P36941 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
29329668
Intra
LTBR P36941 TRAF3 Homo sapiens Q13114
Anti Tag CoIP
28514442
Intra
LTBR P36941 TRAF3 Homo sapiens Q13114
Anti Tag CoIP
20732415
Intra
LTBR P36941 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
33961781
Intra
LTBR P36941 TNFSF14 Homo sapiens O43557
Yeast Display
26977880
Cross
LTBR P36941 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666
Far-WB
8995654
Cross
LTBR P36941 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666
Y2H
8995654
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LTBR Proteins

Cat. No. Product Name Accession Purity
HY-P70345 TNFRSF3/LTBR Protein, Human (HEK293, His) P36941-1 (Q31-M227) ≥95%
HY-P72806 TNFRSF3/LTBR Protein, Human (HEK293, Fc) P36941-1 (Q31-M227) ≥95%

Related Diseases

Diseases Alias
External Ear Basal Cell Carcinoma

Basal Cell Carcinoma Of External Ear

Basal Cell Carcinoma Of The External Ear
External Ear Squamous Cell Carcinoma

Epidermoid Carcinoma Of The External Ear

Squamous Cell Carcinoma Of External Ear
External Ear Carcinoma

Carcinoma Of External Ear

Carcinoma Of The External Ear
Bone Squamous Cell Carcinoma
Inflammatory Bowel Disease 18

IBD18
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07881 LTBR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LTBR VGNC VGNC:42860
Bos taurus LTBR VGNC VGNC:31075
Mus musculus LTBR MGD MGI:104875
Felis catus LTBR VGNC VGNC:68105
Macaca mulatta LTBR VGNC VGNC:100075
Rattus norvegicus LTBR RGD RGD:1309448
Macaca fascicularis LTBR NCBI NCBI:102135920
Others LTBR NCBI