MARK3 - microtubule affinity regulating kinase 3 Gene

Homo sapiens

Also known as KP78; VIPB; CTAK1; PAR1A; Par-1a

Gene ID: 4140 | Gene type: protein coding

About MARK3

Cytogenetic location: 14q32.32-q32.33 Genomic coordinates (GRCh38): 14:103,385,415-103,503,831 (from NCBI)

This gene has 81 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 22.5), testis (RPKM 17.6) and 25 other tissues.

Summary

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

MARK3 Products(7)

mRNA	Protein	Name
NM_001128918.3	NP_001122390.2	MAP/microtubule affinity-regulating kinase 3 isoform a
NM_001128919.3	NP_001122391.2	MAP/microtubule affinity-regulating kinase 3 isoform b
NM_001128920.3	NP_001122392.2	MAP/microtubule affinity-regulating kinase 3 isoform d
NM_001128921.3	NP_001122393.2	MAP/microtubule affinity-regulating kinase 3 isoform e
NM_001411055.1	NP_001397984.1	MAP/microtubule affinity-regulating kinase 3 isoform f
NM_001411056.1	NP_001397985.1	MAP/microtubule affinity-regulating kinase 3 isoform g
NM_002376.7	NP_002367.5	MAP/microtubule affinity-regulating kinase 3 isoform c

MARK3 Protein Structure

Pkinase

KA1

0
200
400
600
753 a.a.

Protein Preferred Names

Protein Names

MAP/microtubule affinity-regulating kinase 3

C-TAK1

MARK3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MARK3	P27448	RIMS1	Homo sapiens	Q86UR5	Anti Bait CoIP	37207277
Intra	MARK3	P27448	HCN1	Homo sapiens	O60741	Anti Bait CoIP	37207277
Cross	MARK3	P27448	ORF9b	Human SARS coronavirus	Q6S8E0	Y2H Pooling	22046132
Cross	MARK3	P27448	ORF9b	Human SARS coronavirus	Q6S8E0	Lumier	22046132
Intra	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
Intra	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Far-WB	15161933
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	25852190
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	TAP	16306228
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	TAP	16306228
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	Pull Down	32707033
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	CoIP	15324660
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	Pull Down	32707033
Intra	MARK3	P27448	SFN	Homo sapiens	P31947	TAP	15778465
Intra	MARK3	P27448	ASB13	Homo sapiens	Q8WXK3	Y2H Pooling	16169070
Cross	MARK3	P27448	Ppm1l	Mus musculus	Q8BHN0	Phosphatase Assay	12556533
Cross	MARK3	P27448	Ppm1l	Mus musculus	Q8BHN0	Anti Bait CoIP	12556533

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Visual Impairment And Progressive Phthisis Bulbi

VIPB	Eye Diseases

Peutz-Jeghers Syndrome

PJS	Polyposis, Hamartomatous Intestinal
Polyps-And-Spots Syndrome	Lentiginosis, Perioral
Periorificial Lentiginosis Syndrome	Hamartomatous Intestinal Polyposis
Hamartomatous Polyp	Colonic Hamartomatous Polyp
Gastric Peutz-Jeghers Polyp	Peutz Jeghers Colon Polyp
Peutz Jeghers Polyp	Peutz-Jeghers Polyp Of Small Intestine
Peutz-Jeghers Small Bowel Hamartoma	Peutz Jeghers Polyposis
Intestinal Polyposis-Cutaneous Pigmentation Syndrome	Peutz-Jeghers Polyposis
Polyposis, Intestinal, Ii	Intestinal Hamartomatous Polyposis
Peutz-Jeghers Polyp	Peutz-Jeghers Polyp Of The Stomach
Peutz Jehgers Polyp	Peutz-Jeghers Polyps Of Small Bowel

Acute Cystitis

Urinary Tract Infection

Recurrent Urinary Tract Infection

Gaucher Disease, Type Iii

Gaucher Disease, Subacute Neuronopathic Type	Gd Iii
Gaucher Disease, Chronic Neuronopathic Type	Gaucher Disease, Juvenile And Adult, Cerebral
Gaucher Disease Type 3	GD3
Gaucher'S Disease Type Iii	Gaucher Disease Type Iii
Gd 3	Cerebral Juvenile And Adult Form Of Gaucher Disease
Chronic Neuronopathic Gaucher Disease	Gaucher Disease 3
Cerebral, Juvenile And Adult, Gaucher Disease	Gaucher Disease Chronic Neuronopathic Type
Gaucher Disease Type Ii	Subacute Neuronopathic Gaucher Disease
Type 3 Gaucher Disease	Gaucher Disease, Type 3
Gaucher Disease, Type 2

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120877	MRT199665		99.74%	Unkown
HY-139604	PCC0208017		99.56%	Unkown
HY-120877A	(R)-MRT199665		98.70%	Unkown
HY-RS08151	MARK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MARK3	MGD	MGI:1341865
Canis familiaris	MARK3	VGNC	VGNC:43025
Macaca mulatta	MARK3	VGNC	VGNC:74659
Bos taurus	MARK3	VGNC	VGNC:31249
Felis catus	MARK3	VGNC	VGNC:68185
Rattus norvegicus	MARK3	RGD	RGD:619883

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