MNDA - myeloid cell nuclear differentiation antigen Gene

Homo sapiens

Also known as PYHIN3

Gene ID: 4332 | Gene type: protein coding

About MNDA

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,831,351-158,849,502 (from NCBI)

This gene has 3 transcripts (splice variants), 48 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 108.7), appendix (RPKM 52.2) and 7 other tissues.

Summary

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

MNDA Products(1)

mRNA	Protein	Name
NM_002432.3	NP_002423.1	myeloid cell nuclear differentiation antigen

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17875758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MNDA Protein Structure

PYRIN

HIN

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

myeloid cell nuclear differentiation antigen

epididymis secretory sperm binding protein

MNDA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MNDA	P41218	MET	Homo sapiens	P08581	Validated Y2H	32814053
Intra	MNDA	P41218	MET	Homo sapiens	P08581	Y2H Array	32814053
Intra	MNDA	P41218	MET	Homo sapiens	P08581	Y2H Pooling	32814053
Intra	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	MNDA	P41218	NSD3	Homo sapiens	Q9BZ95	Y2H	23455924
Intra	MNDA	P41218	NSD3	Homo sapiens	Q9BZ95	Anti Tag CoIP	23455924
Intra	MNDA	P41218	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	MNDA	P41218	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	MNDA	P41218	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	MNDA	P41218	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	MNDA	P41218	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	MNDA	P41218	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	MNDA	P41218	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	MNDA	P41218	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	MNDA	P41218	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
Intra	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	MNDA	P41218	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	MNDA	P41218	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	MNDA	P41218	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Methotrexate-Associated Lymphoproliferation

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

Parkinson Disease 4, Autosomal Dominant

Autosomal Dominant Parkinson Disease 4	PARK4
Parkinson Disease 4, Autosomal Dominant Lewy Body	Parkinson Disease 4
Parkinson'S Disease 4	Autosomal Dominant Lewy Body Parkinson Disease 4
Autosomal Dominant Parkinson'S Disease 4	Parkinson Disease 4 Autosomal Dominant Lewy Body
Parkinson Disease Autosomal Dominant 4	Parkinson Disease Familial Type 4
Parkinson Disease, Type 4

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160018	BAY-155	Inhibitor	/	Unkown
HY-RS08568	MNDA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MNDA	VGNC	VGNC:53122
Macaca mulatta	MNDA	VGNC	VGNC:74906

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