PALM - paralemmin Gene

Homo sapiens

Also known as PALM1

Gene ID: 5064 | Gene type: protein coding

About PALM

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:708,935-748,329 (from NCBI)

This gene has 11 transcripts (splice variants), 235 orthologues and 3 paralogues. Broad expression in fat (RPKM 28.7), brain (RPKM 22.8) and 18 other tissues.

Summary

This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and Other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

PALM Products(2)

mRNA	Protein	Name
NM_001040134.2	NP_001035224.1	paralemmin-1 isoform 2
NM_002579.3	NP_002570.2	paralemmin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16386234	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	16386234	GOA
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	14978216	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in filopodium membrane	IDA IDA: Inferred from direct assay	14978216	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16386234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALM Protein Structure

Paralemmin

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

paralemmin-1

PALM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PALM	O75781	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	PALM	O75781	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	PALM	O75781	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Osteopetrosis, Autosomal Dominant 2

OPTA2	Autosomal Dominant Osteopetrosis 2
Osteopetrosis Autosomal Dominant Type 2	Osteopetrosis, Autosomal Dominant, Type Ii
Albers-Schonberg Osteopetrosis	Autosomal Dominant Albers-Schonberg Disease
Osteopetrosis	Marble Bones, Autosomal Dominant
Osteosclerosis Fragilis Generalisata	Albers-Schonberg Disease, Autosomal Dominant
Autosomal Dominant Osteopetrosis Type Ii	Albers-Schönberg Osteopetrosis
Autosomal Dominant Osteopetrosis Type 2	Marble Disease Autosomal Dominant
Osteopetrosis, Autosomal Dominant, Type 2

Pettigrew Syndrome

PGS	Mrxs5
Mrx59	Mrxs21
X-Linked Intellectual Disability-Dandy-Walker Malformation-Basal Ganglia Disease-Seizures Syndrome	Mental Retardation, X-Linked, Syndromic 5
Mrxsf	Syndromic X-Linked Intellectual Disability 5
Fried Syndrome	Mental Retardation, X-Linked Syndromic 5
Mental Retardation, X-Linked, With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures	Mental Retardation, X-Linked, Syndromic, Fried Type
Mental Retardation, X-Linked, Syndromic 21	Syndromic X-Linked Mental Retardation 21
Syndromic X-Linked Mental Retardation Fried Type	X-Linked Metal Retardation With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures
Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease An	Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease And Seizures
X-Linked Syndromic Intellectual Disability 5	X-Linked Intellectual Disability With Dandy-Walker Malformation Basal Ganglia Disease And Seizures
X-Linked Intellectual Disability - Dandy-Walker Malformation - Basal Ganglia Disease - Seizures	X-Linked Intellectual Disability-Hypotonia-Facial Dysmorphism-Aggressive Behavior Syndrome
Mental Retardation, X-Linked Syndromic, Fried Type	Dandy-Walker Malformation With Mental Retardation, Basal Ganglia Disease, And Seizures
Mental Retardation, X-Linked 59

Differentiating Neuroblastoma

Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii	Isolated Growth Hormone Deficiency Type Ii
IGHD2	Growth Hormone Deficiency, Isolated, Type Ii
Congenital Ighd Type Ii	Congenital Isolated Gh Deficiency Type Ii
Congenital Isolated Growth Hormone Deficiency Type Ii	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant
Growth Hormone Deficiency, Isolated, Autosomal Dominant	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant
Autosomal Dominant Isolated Growth Hormone Deficiency	Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 2	Growth Hormone Deficiency, Isolated Autosomal Dominant
Growth Hormone Deficiency, Isolated, 2	Growth Hormone Deficiency Isolated Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10031A	SAR441255 TFA	Agonist	99.65%	Phase 1
HY-P10031	SAR441255	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2041	Myristic acid		≥98.0%	Unkown
HY-N0773	Isovitexin	Inhibitor	99.82%	Unkown
HY-N2041S	Myristic acid-d27		98.83%	Unkown
HY-135087	Caprylic/Capric Triglyceride		≥97.0%	Unkown
HY-N2041S3	Myristic acid-d3		98.62%	Unkown
HY-N2041S6	Myristic acid-d5		≥98.0%	Unkown
HY-P0064	Palmitoyl Tetrapeptide-3	Inhibitor	99.20%	Unkown
HY-148702	di-Pal-MTO		98.37%	Unkown
HY-N2041S7	Myristic acid-d7		99.80%	Unkown
HY-W013788	2-Palmitoylglycerol	Agonist	≥99.0%	Unkown
HY-B0828	Triazophos		/	Unkown
HY-D1196	Direct Blue 71		/	Unkown
HY-120634	BMS-929075	Inhibitor	/	Unkown
HY-128430	Farnesyl acetate		/	Unkown
HY-133535	PA Janelia Fluor® 646, SE		/	Unkown
HY-145519	Mu-6S-Palm-β-Glc		/	Unkown
HY-148701	mono-Pal-MTO		/	Unkown
HY-157172	MorHap	Inhibitor	/	Unkown
HY-N2041S1	Myristic acid-d2		/	Unkown
HY-N2041S2	Myristic acid-13C		/	Unkown
HY-N2041S4	Myristic acid-13C3		/	Unkown
HY-N2041S5	Myristic acid-d1		/	Unkown
HY-N7813	1,2-Dipalmitoyl-3-oleoylglycerol		/	Unkown
HY-P10379	palm-PrRP31	Agonist	/	Unkown
HY-P10380	palm11-PrRP31	Agonist	/	Unkown
HY-RS10005	PALM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10006	PALM2AKAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10007	PALM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W010736A	1,2-Dipalmitoyl-rac-glycerol		/	Unkown
HY-W099600	Lauric anhydride		/	Unkown
HY-W250170	Decyl glucoside		/	Unkown
HY-10467	HCV-796 analog	Inhibitor	/	Unkown
HY-W010667	(Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate		/	Unkown
HY-W710399	2-Hydroxy-3-(palmitoyloxy)propyl stearate		/	Unkown
HY-W710976	4-Methyl-5-nonanone		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PALM	VGNC	VGNC:32558
Macaca mulatta	PALM	VGNC	VGNC:75751
Felis catus	PALM	VGNC	VGNC:102653
Canis familiaris	PALM	VGNC	VGNC:54980
Rattus norvegicus	PALM	RGD	RGD:620341
Mus musculus	PALM	MGD	MGI:1261814
Others	PALM	NCBI

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