2. Gene
  3. PARD6A - par-6 family cell polarity regulator alpha Gene

PARD6A - par-6 family cell polarity regulator alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

Gene ID: 50855 | Gene type: protein coding

About PARD6A

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,660,960-67,662,774 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 2 paralogues. Broad expression in testis (RPKM 9.8), brain (RPKM 5.0) and 23 other tissues.

Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

PARD6A Products(2)

mRNA Protein Name
NM_001037281.2 NP_001032358.1 partitioning defective 6 homolog alpha isoform 2
NM_016948.3 NP_058644.1 partitioning defective 6 homolog alpha isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10934474 GOA
Biological Process GO Annotation Evidence Reference Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
20719959 GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity IDA
IDA: Inferred from direct assay
11257119 GOA
involved in positive regulation of protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
20719959 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PAR polarity complex IPI
IPI: Inferred from physical interaction
11257119 GOA
located in centriolar satellite IDA
IDA: Inferred from direct assay
20719959 GOA
located in centrosome IDA
IDA: Inferred from direct assay
20719959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARD6A Protein Structure

PB1

PB1: PB1 domain (16 - 94)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (158 - 246)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

partitioning defective 6 homolog alpha

PAR-6 alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10038 PARD6A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PARD6A VGNC VGNC:44265
Mus musculus PARD6A MGD MGI:1927223
Rattus norvegicus PARD6A RGD RGD:1303273
Felis catus PARD6A VGNC VGNC:64041
Bos taurus PARD6A VGNC VGNC:32583
Macaca mulatta PARD6A VGNC VGNC:104743