PARD6A - par-6 family cell polarity regulator alpha Gene

Homo sapiens

Also known as PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

Gene ID: 50855 | Gene type: protein coding

About PARD6A

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,660,960-67,662,774 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 2 paralogues. Broad expression in testis (RPKM 9.8), brain (RPKM 5.0) and 23 other tissues.

Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

PARD6A Products(2)

mRNA	Protein	Name
NM_001037281.2	NP_001032358.1	partitioning defective 6 homolog alpha isoform 2
NM_016948.3	NP_058644.1	partitioning defective 6 homolog alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10934474	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	20719959	GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: Inferred from direct assay	11257119	GOA
involved in positive regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	20719959	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PAR polarity complex	IPI IPI: Inferred from physical interaction	11257119	GOA
located in centriolar satellite	IDA IDA: Inferred from direct assay	20719959	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20719959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARD6A Protein Structure

PB1

PDZ

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

partitioning defective 6 homolog alpha

PAR-6 alpha

PARD6A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	Y2H	11257119
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	Y2H	21516116
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	Validated Y2H	25416956
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	26496610
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	Y2H Array	25416956
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	Anti Bait CoIP	17057644
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	14676191
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	CoIP	11257119
Intra	PARD6A	Q9NPB6	PRKCI	Homo sapiens	P41743	X-Ray Diffraction	15590654
Intra	PARD6A	Q9NPB6	CDH5	Homo sapiens	P33151	Pull Down	17057644
Intra	PARD6A	Q9NPB6	CDH5	Homo sapiens	P33151	Anti Bait CoIP	17057644
Intra	PARD6A	Q9NPB6	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	17350623
Intra	PARD6A	Q9NPB6	PRKCZ	Homo sapiens	Q05513	Imaging	17057644
Intra	PARD6A	Q9NPB6	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	14676191
Intra	PARD6A	Q9NPB6	CDC42	Homo sapiens	P60953	Pull Down	11260256
Intra	PARD6A	Q9NPB6	CDC42	Homo sapiens	P60953	Anti Tag CoIP	14676191
Intra	PARD6A	Q9NPB6	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	14676191
Intra	PARD6A	Q9NPB6	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	26496610
Intra	PARD6A	Q9NPB6	PARD3	Homo sapiens	Q8TEW0	CoIP	11257119

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10038	PARD6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PARD6A	VGNC	VGNC:44265
Mus musculus	PARD6A	MGD	MGI:1927223
Rattus norvegicus	PARD6A	RGD	RGD:1303273
Felis catus	PARD6A	VGNC	VGNC:64041
Bos taurus	PARD6A	VGNC	VGNC:32583
Macaca mulatta	PARD6A	VGNC	VGNC:104743

Name
Email *

	Sorry, but the email address you supplied was invalid.