PARD3 - par-3 family cell polarity regulator Gene

Homo sapiens

Also known as Baz; ASIP; PAR3; PARD-3; PARD3A; SE2-5T2; PPP1R118; SE2-5L16; SE2-5LT1; PAR3alpha

Gene ID: 56288 | Gene type: protein coding

About PARD3

Cytogenetic location: 10p11.22-p11.21 Genomic coordinates (GRCh38): 10:34,109,561-34,815,296 (from NCBI)

This gene has 16 transcripts (splice variants), 267 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 6.9), skin (RPKM 6.8) and 24 other tissues.

Summary

This gene encodes a member of the PARD protein family. PARD family members interact with Other PARD family members and Other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

PARD3 Products(11)

mRNA	Protein	Name
NM_001184785.2	NP_001171714.1	partitioning defective 3 homolog isoform 2
NM_001184786.2	NP_001171715.1	partitioning defective 3 homolog isoform 3
NM_001184787.2	NP_001171716.1	partitioning defective 3 homolog isoform 4
NM_001184788.2	NP_001171717.1	partitioning defective 3 homolog isoform 5
NM_001184789.2	NP_001171718.1	partitioning defective 3 homolog isoform 6
NM_001184790.2	NP_001171719.1	partitioning defective 3 homolog isoform 7
NM_001184791.2	NP_001171720.1	partitioning defective 3 homolog isoform 8
NM_001184792.2	NP_001171721.1	partitioning defective 3 homolog isoform 9
NM_001184793.2	NP_001171722.1	partitioning defective 3 homolog isoform 10
NM_001184794.2	NP_001171723.1	partitioning defective 3 homolog isoform 11
NM_019619.4	NP_062565.2	partitioning defective 3 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10934474	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: Inferred from direct assay	11257119	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PAR polarity complex	IPI IPI: Inferred from physical interaction	11257119	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	14676191	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	20332120	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARD3 Protein Structure

DUF3534

PDZ

0
300
600
900
1200
1356 a.a.

Protein Preferred Names

Protein Names

partitioning defective 3 homolog

CTCL tumor antigen se2-5

PARD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PARD3	Q8TEW0	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	14676191
Intra	PARD3	Q8TEW0	CDH5	Homo sapiens	P33151	Imaging	17057644
Intra	PARD3	Q8TEW0	CDH5	Homo sapiens	P33151	Pull Down	17057644
Intra	PARD3	Q8TEW0	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	14676191
Intra	PARD3	Q8TEW0	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
Intra	PARD3	Q8TEW0	PNMA1	Homo sapiens	Q8ND90	Anti Tag CoIP	14676191
Intra	PARD3	Q8TEW0	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
Intra	PARD3	Q8TEW0	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	PARD3	Q8TEW0	F11R	Homo sapiens	Q9Y624	Pull Down	17057644
Cross	PARD3	Q8TEW0	Tiam2	Mus musculus	Q6ZPF3	Pull Down	19893486
Cross	PARD3	Q8TEW0	Tiam2	Mus musculus	Q6ZPF3	SPR	19893486
Intra	PARD3	Q8TEW0	PARD6A	Homo sapiens	Q9NPB6	Anti Bait CoIP	17057644
Intra	PARD3	Q8TEW0	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	14676191
Intra	PARD3	Q8TEW0	PARD6A	Homo sapiens	Q9NPB6	CoIP	11257119
Cross	PARD3	Q8TEW0	Prkci	Mus musculus	Q62074	Protein Kinase Assay	22579248
Cross	PARD3	Q8TEW0	Prkci	Mus musculus	Q62074	Pull Down	22579248

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Myelomeningocele

Meningomyelocele

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10037	PARD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PARD3	VGNC	VGNC:44263
Rattus norvegicus	PARD3	RGD	RGD:620374
Mus musculus	PARD3	MGD	MGI:2135608
Felis catus	PARD3	VGNC	VGNC:64040
Bos taurus	PARD3	VGNC	VGNC:32582
Macaca mulatta	PARD3	VGNC	VGNC:75618

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