2. Gene
  3. SLC30A4 - solute carrier family 30 member 4 Gene

SLC30A4 - solute carrier family 30 member 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZNT4; znT-4

Gene ID: 7782 | Gene type: protein coding

About SLC30A4

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,479,606-45,522,755 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 8 paralogues. Biased expression in prostate (RPKM 22.0), testis (RPKM 4.0) and 12 other tissues.

Summary

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

SLC30A4 Products(2)

mRNA Protein Name
NM_001321036.2 NP_001307965.1 zinc transporter 4 isoform 2
NM_013309.6 NP_037441.2 zinc transporter 4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25657003 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
17349999 GOA
Biological Process GO Annotation Evidence Reference Source
involved in response to toxic substance IDA
IDA: Inferred from direct assay
17575980 GOA
involved in zinc ion import into lysosome IDA
IDA: Inferred from direct assay
17349999 GOA
involved in zinc ion transmembrane transport IDA
IDA: Inferred from direct assay
19521526 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17349999 GOA
located in late endosome IDA
IDA: Inferred from direct assay
17349999 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A4 Protein Structure

Cation_efflux

Cation_efflux: Cation efflux family (114 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
Protein Preferred Names Protein Names

zinc transporter 4

solute carrier family 30 (zinc transporter), member 4

SLC30A4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC30A4 O14863 SLC30A3 Homo sapiens Q99726
BiFC
25657003
Intra
SLC30A4 O14863 SLC30A3 Homo sapiens Q99726
Anti Tag CoIP
26728129
Intra
SLC30A4 O14863 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
SLC30A4 O14863 SLC30A10 Homo sapiens Q6XR72
Crosslink
26728129
Intra
SLC30A4 O14863 SLC30A10 Homo sapiens Q6XR72
Anti Tag CoIP
26728129
Intra
SLC30A4 O14863 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
SLC30A4 O14863 TNF Homo sapiens P01375
Validated Y2H
32296183
Intra
SLC30A4 O14863 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra
SLC30A4 O14863 NSG1 Homo sapiens P42857
Validated Y2H
32296183
Intra
SLC30A4 O14863 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Intra
SLC30A4 O14863 FZD7 Homo sapiens O75084
Validated Y2H
32296183
Intra
SLC30A4 O14863 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra
SLC30A4 O14863 LEPROTL1 Homo sapiens O95214
Validated Y2H
32296183
Intra
SLC30A4 O14863 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra
SLC30A4 O14863 SLC30A2 Homo sapiens Q9BRI3
BiFC
25657003
Intra
SLC30A4 O14863 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
Intra
SLC30A4 O14863 BTN2A2 Homo sapiens Q8WVV5
Validated Y2H
32296183
Cross
SLC30A4 O14863 Tfrc Rattus norvegicus Q99376
Anti Tag CoIP
26728129
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
Acrodermatitis
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like

Scd-Eds

EDSSPD3

Ehlers-Danlos Syndrome Spondylodysplastic Type 3

Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type

Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome

Slc39a13-Related Speds

Slc39a13-Related Spondylodysplastic Eds

Spondylocheirodysplastic Ehlers-Danlos Syndrome

Speds-Slc39a13

Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia

Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13182 SLC30A4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC30A4 VGNC VGNC:49968
Felis catus SLC30A4 VGNC VGNC:65310
Mus musculus SLC30A4 MGD MGI:1345282
Rattus norvegicus SLC30A4 RGD RGD:619750
Canis familiaris SLC30A4 VGNC VGNC:46349
Macaca mulatta SLC30A4 VGNC VGNC:77454
Others SLC30A4 NCBI