FZR1 - fizzy and cell division cycle 20 related 1 Gene

Homo sapiens

Also known as FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C; DEE109

Gene ID: 51343 | Gene type: protein coding

About FZR1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,506,311-3,538,334 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 11.7), bone marrow (RPKM 10.3) and 25 other tissues.

Summary

Predicted to enable anaphase-promoting complex binding activity and ubiquitin Ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colocalizes with anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]

FZR1 Products(3)

mRNA	Protein	Name
NM_001136197.1	NP_001129669.1	fizzy-related protein homolog isoform 3
NM_001136198.1	NP_001129670.1	fizzy-related protein homolog isoform 1
NM_016263.4	NP_057347.2	fizzy-related protein homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10548110	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	14701726	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	14701726	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	18662541	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11459826	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	34788397	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZR1 Protein Structure

WD40

0
100
200
300
400
496 a.a.

Protein Preferred Names

Protein Names

fizzy-related protein homolog

CDC20 homolog 1

FZR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FZR1	Q9UM11	CLSPN	Homo sapiens	Q9HAW4	Anti Tag CoIP	18662541
Intra	FZR1	Q9UM11	CLSPN	Homo sapiens	Q9HAW4	Pull Down	18662541
Intra	FZR1	Q9UM11	RRM2	Homo sapiens	P31350	Anti Tag CoIP	33961781
Intra	FZR1	Q9UM11	VHL	Homo sapiens	P40337	Anti Bait CoIP	20802534
Intra	FZR1	Q9UM11	VHL	Homo sapiens	P40337-3	Anti Bait CoIP	20802534
Intra	FZR1	Q9UM11	VHL	Homo sapiens	P40337-1	Pull Down	20802534
Intra	FZR1	Q9UM11	VHL	Homo sapiens	P40337-1	Anti Bait CoIP	20802534
Intra	FZR1	Q9UM11	MAK	Homo sapiens	P20794	Anti Bait CoIP	21986944
Intra	FZR1	Q9UM11	MAK	Homo sapiens	P20794	Protein Kinase Assay	21986944
Intra	FZR1	Q9UM11	SKP2	Homo sapiens	Q13309	Anti Tag CoIP	33961781
Intra	FZR1	Q9UM11	MAD2L2	Homo sapiens	Q9UI95	Pull Down	17719540
Intra	FZR1	Q9UM11	RAD17	Homo sapiens	O75943	Anti Bait CoIP	20424596
Intra	FZR1	Q9UM11	CDC27	Homo sapiens	P30260	Anti Tag CoIP	18662541
Intra	FZR1	Q9UM11	CDC27	Homo sapiens	P30260	Anti Tag CoIP	22014574
Intra	FZR1	Q9UM11	CDC27	Homo sapiens	P30260	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05186	FZR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FZR1	VGNC	VGNC:62408
Canis familiaris	FZR1	VGNC	VGNC:41036
Macaca mulatta	FZR1	VGNC	VGNC:72774
Bos taurus	FZR1	VGNC	VGNC:29173
Rattus norvegicus	FZR1	RGD	RGD:1308713
Mus musculus	FZR1	MGD	MGI:1926790

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