EIF3L - eukaryotic translation initiation factor 3 subunit L Gene

Homo sapiens

Also known as EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP

Gene ID: 51386 | Gene type: protein coding

About EIF3L

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,849,419-37,889,407 (from NCBI)

This gene has 15 transcripts (splice variants) and 225 orthologues. Ubiquitous expression in ovary (RPKM 248.8), thyroid (RPKM 164.0) and 25 other tissues.

Summary

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3L Products(3)

mRNA	Protein	Name
NM_001242923.2	NP_001229852.1	eukaryotic translation initiation factor 3 subunit L isoform 2
NM_001363785.2	NP_001350714.1	eukaryotic translation initiation factor 3 subunit L isoform 3
NM_016091.4	NP_057175.1	eukaryotic translation initiation factor 3 subunit L isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA
involved in viral translational termination-reinitiation	IDA IDA: Inferred from direct assay	21347434	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3L Protein Structure

Paf67

0
100
200
300
400
500
564 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit L

eIEF associated protein HSPC021

EIF3L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3L	Q9Y262	EIF3E	Homo sapiens	P60228	Pull Down	23623729
Intra	EIF3L	Q9Y262	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	18599441
Intra	EIF3L	Q9Y262	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	33961781
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	28514442
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	18599441
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Y2H Array	32296183
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	SLCA	19748344
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Pull Down	23623729
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Y2H Prey Pooling	25416956
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	33961781
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Validated Y2H	25416956
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Y2H Prey Pooling	32296183
Intra	EIF3L	Q9Y262	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Cross	EIF3L	Q9Y262	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Yellow Fever

Urban Yellow Fever	Jungle Yellow Fever
Sylvatic Yellow Fever	Yf
Yellow Fever, Sylvan	Bronze John
Yellow Jack	Yf- [Yellow Fever]
Febris Flava

Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH	Bone Dysplasia With Medullary Fibrosarcoma
Bdmf	Bone Dysplasia With Malignant Fibrous Histiocytoma
Hardcastle Syndrome	Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome
Myopathy, Limb-Girdle, With Bone Fragility	Bone Dysplasia-Medullary Fibrosarcoma Syndrome
Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome	Dms-Mfh
Limb-Girdle Myopathy With Bone Fragility	Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04268	EIF3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EIF3L	VGNC	VGNC:61786
Mus musculus	EIF3L	MGD	MGI:2386251
Rattus norvegicus	EIF3L	RGD	RGD:1308230
Bos taurus	EIF3L	VGNC	VGNC:28402
Canis familiaris	EIF3L	VGNC	VGNC:40278
Macaca mulatta	EIF3L	VGNC	VGNC:84764

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