2. Gene
  3. EIF3B - eukaryotic translation initiation factor 3 subunit B Gene

EIF3B - eukaryotic translation initiation factor 3 subunit B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116

Gene ID: 8662 | Gene type: protein coding

About EIF3B

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,354,086-2,380,745 (from NCBI)

This gene has 12 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues.

Summary

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3B Products(5)

mRNA Protein Name
NM_001037283.2 NP_001032360.1 eukaryotic translation initiation factor 3 subunit B isoform 1
NM_001362791.2 NP_001349720.1 eukaryotic translation initiation factor 3 subunit B isoform 1
NM_001362792.2 NP_001349721.1 eukaryotic translation initiation factor 3 subunit B isoform 2
NM_001362793.2 NP_001349722.1 eukaryotic translation initiation factor 3 subunit B isoform 2
NM_003751.4 NP_003742.2 eukaryotic translation initiation factor 3 subunit B isoform 1

EIF3B Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (207 - 257)

eIF2A

eIF2A: Eukaryotic translation initiation factor eIF2A (507 - 701)

  • 0
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  • 600
  • 814 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit B

eukaryotic translation initiation factor 3 subunit 9

Related Diseases

Diseases Alias
Craniotubular Dysplasia, Ikegawa Type

CTDI

Craniotubular Dysplasia Ikegawa Type

Doid:0112340
Mouth Disease

Mouth Diseases

Mouth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04258 EIF3B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EIF3B VGNC VGNC:72193
Bos taurus EIF3B VGNC VGNC:28393
Rattus norvegicus EIF3B RGD RGD:1309018
Canis familiaris EIF3B VGNC VGNC:40269
Felis catus EIF3B VGNC VGNC:61781
Mus musculus EIF3B MGD MGI:106478