EIF3B - eukaryotic translation initiation factor 3 subunit B Gene

Homo sapiens

Also known as PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116

Gene ID: 8662 | Gene type: protein coding

About EIF3B

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,354,086-2,380,745 (from NCBI)

This gene has 12 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues.

Summary

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3B Products(5)

mRNA	Protein	Name
NM_001037283.2	NP_001032360.1	eukaryotic translation initiation factor 3 subunit B isoform 1
NM_001362791.2	NP_001349720.1	eukaryotic translation initiation factor 3 subunit B isoform 1
NM_001362792.2	NP_001349721.1	eukaryotic translation initiation factor 3 subunit B isoform 2
NM_001362793.2	NP_001349722.1	eukaryotic translation initiation factor 3 subunit B isoform 2
NM_003751.4	NP_003742.2	eukaryotic translation initiation factor 3 subunit B isoform 1

EIF3B Protein Structure

RRM_1

eIF2A

0
200
400
600
814 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit B

eukaryotic translation initiation factor 3 subunit 9

EIF3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3B	P55884	RPS6KB1	Homo sapiens	P23443	Anti Bait CoIP	18423201
Intra	EIF3B	P55884	RPS6KB1	Homo sapiens	P23443	Anti Bait CoIP	21986499
Intra	EIF3B	P55884	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	18599441
Intra	EIF3B	P55884	EIF3E	Homo sapiens	P60228	SLCA	18599441
Intra	EIF3B	P55884	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3E	Homo sapiens	P60228	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	DDX3X	Homo sapiens	O00571	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	18599441
Intra	EIF3B	P55884	EIF3M	Homo sapiens	Q7L2H7	SLCA	18599441
Intra	EIF3B	P55884	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	14688252
Intra	EIF3B	P55884	EIF3I	Homo sapiens	Q13347	SLCA	18599441
Intra	EIF3B	P55884	EIF3I	Homo sapiens	Q13347	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3K	Homo sapiens	Q9UBQ5	SLCA	18599441
Intra	EIF3B	P55884	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	18599441
Intra	EIF3B	P55884	EIF3K	Homo sapiens	Q9UBQ5	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3A	Homo sapiens	Q14152	Anti Bait CoIP	19245811
Intra	EIF3B	P55884	EIF3A	Homo sapiens	Q14152	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	14688252
Intra	EIF3B	P55884	EIF3G	Homo sapiens	O75821	SLCA	18599441
Intra	EIF3B	P55884	EIF3G	Homo sapiens	O75821	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3G	Homo sapiens	O75821	Anti Tag CoIP	14688252
Intra	EIF3B	P55884	EIF3G	Homo sapiens	O75821	Crosslink	30021884
Intra	EIF3B	P55884	EIF3G	Homo sapiens	O75821	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3J	Homo sapiens	O75822	Anti Tag CoIP	14688252
Intra	EIF3B	P55884	EIF3J	Homo sapiens	O75822	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3J	Homo sapiens	O75822	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3L	Homo sapiens	Q9Y262	Anti Tag CoIP	18599441
Intra	EIF3B	P55884	EIF3L	Homo sapiens	Q9Y262	SLCA	18599441
Intra	EIF3B	P55884	EIF3L	Homo sapiens	Q9Y262	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3H	Homo sapiens	O15372	SLCA	18599441
Intra	EIF3B	P55884	EIF3H	Homo sapiens	O15372	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3H	Homo sapiens	O15372	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3H	Homo sapiens	O15372	Anti Tag CoIP	18599441
Intra	EIF3B	P55884	EIF3F	Homo sapiens	O00303	Anti Bait CoIP	18628297
Intra	EIF3B	P55884	EIF3F	Homo sapiens	O00303	Anti Tag CoIP	35271311
Intra	EIF3B	P55884	EIF3F	Homo sapiens	O00303	Anti Tag CoIP	18599441
Intra	EIF3B	P55884	EIF3F	Homo sapiens	O00303	SLCA	18599441
Intra	EIF3B	P55884	EIF3F	Homo sapiens	O00303	Anti Bait CoIP	19245811
Intra	EIF3B	P55884	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	23023399
Intra	EIF3B	P55884	EIF4G1	Homo sapiens	Q04637	Anti Tag CoIP	35271311
Cross	EIF3B	P55884	UL54	Human herpesvirus 1	Q9J0X9	Pull Down	15567442

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF3B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83000	eIF3B Antibody (YA2745)	WB, IHC-P	Human

Related Diseases

Diseases

Alias

Craniotubular Dysplasia, Ikegawa Type

CTDI	Craniotubular Dysplasia Ikegawa Type
Doid:0112340

Mouth Disease

Mouth Diseases

Mouth Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04258	EIF3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EIF3B	VGNC	VGNC:72193
Bos taurus	EIF3B	VGNC	VGNC:28393
Rattus norvegicus	EIF3B	RGD	RGD:1309018
Canis familiaris	EIF3B	VGNC	VGNC:40269
Felis catus	EIF3B	VGNC	VGNC:61781
Mus musculus	EIF3B	MGD	MGI:106478

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