2. Gene
  3. PDE4B - phosphodiesterase 4B Gene

PDE4B - phosphodiesterase 4B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DPDE4; PDEIVB

Gene ID: 5142 | Gene type: protein coding

About PDE4B

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:65,792,510-66,374,579 (from NCBI)

This gene has 18 transcripts (splice variants), 290 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues.

Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

PDE4B Products(7)

mRNA Protein Name
NM_001037339.2 NP_001032416.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2
NM_001037340.3 NP_001032417.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3
NM_001037341.2 NP_001032418.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
NM_001297440.2 NP_001284369.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 4
NM_001297441.1 NP_001284370.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 5
NM_001297442.2 NP_001284371.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6
NM_002600.4 NP_002591.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

PDE4B Protein Structure

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (405 - 649)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

dunce-like phosphodiesterase E4

Related Diseases

Diseases Alias
Ocular Hypotension

Hypotony Of Eye
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Brugada Syndrome 3

BRGDA3

Brugada Syndrome, Type 3
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities

Scn8

Sdsl

Shwachman-Diamond Syndrome-Like
Acrodysostosis

Acrodysplasia

Arkless-Graham Syndrome

Maroteaux-Malamut Syndrome

Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-153192 Nerandomilast Inhibitor 99.93% Phase 3
HY-153192A Nerandomilast dihydrate Inhibitor / Phase 3
HY-16900 Rolipram Inhibitor 99.58% Phase 2
HY-10469 GSK256066 Inhibitor 98.15% Phase 2
HY-117960 Orismilast Inhibitor 99.37% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-70069 GSK256066 Trifluoroacetate Inhibitor 99.54% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128358 MR-L2 Activator 99.23% Unkown
HY-122942 Moracin M 98.90% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.21% Unkown
HY-16900A (R)-(-)-Rolipram Inhibitor 99.89% Unkown
HY-147830 PDE4B-IN-3 Inhibitor 99.40% Unkown
HY-119190 PF-06445974 Inhibitor 98.23% Unkown
HY-103050 ML-030 Inhibitor 99.50% Unkown
HY-131707 LEO 39652 Inhibitor 99.51% Unkown
HY-100246 CI-1044 Inhibitor 98.02% Unkown
HY-117977 FCPR03 Inhibitor 99.82% Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-121162 Mesembrine Inhibitor / Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor / Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-146201 PDE4B/7A-IN-1 / Unkown
HY-146202 PDE4B/7A-IN-2 / Unkown
HY-147950 PDE4-IN-10 Inhibitor / Unkown
HY-159654 PDE4-IN-19 Inhibitor / Unkown
HY-161851 MDL3 Inhibitor / Unkown
HY-162582 Z19153 Inhibitor / Unkown
HY-162583 PDE4-IN-17 Inhibitor / Unkown
HY-163604 PDE4B/D-IN-1 Inhibitor / Unkown
HY-163605 PDE4B/D-IN-2 Inhibitor / Unkown
HY-163606 PDE4B/D-IN-3 Inhibitor / Unkown
HY-168558 PDE4B/D-IN-4 Inhibitor / Unkown
HY-RS10223 PDE4B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-119799 UK-500001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDE4B VGNC VGNC:75916
Rattus norvegicus PDE4B RGD RGD:3280
Bos taurus PDE4B VGNC VGNC:32676
Felis catus PDE4B VGNC VGNC:82496
Mus musculus PDE4B MGD MGI:99557
Canis familiaris PDE4B VGNC VGNC:44354