1. Gene
  2. PDK1 - pyruvate dehydrogenase kinase 1 Gene

PDK1 - pyruvate dehydrogenase kinase 1 Gene

Homo sapiens
Gene ID: 5163 | Gene type: protein coding

About PDK1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:172,555,373-172,724,312 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 4.7), adrenal (RPKM 4.3) and 25 other tissues.

Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major Enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

PDK1 Products(36)

mRNA Protein Name
XR_427093.4
XM_047444740.1 XP_047300696.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X7
XR_007076392.1
XR_007076402.1
NR_103729.2
XR_001738771.2
XR_922944.3
XR_007076401.1
XR_007076399.1
XR_922945.1
XR_007076391.1
XR_007076400.1
XR_007076403.1
XM_006712594.3 XP_006712657.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X6
XR_922942.2
XR_007076393.1
XM_047444736.1 XP_047300692.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XM_011511344.3 XP_011509646.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XR_007076398.1
XM_047444739.1 XP_047300695.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X5
XR_001738775.3
XR_922943.2
XR_007076394.1
XM_011511347.3 XP_011509649.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XM_047444737.1 XP_047300693.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X3
XM_011511345.4 XP_011509647.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XR_007076395.1
XR_001738774.3
XR_001738772.3
XR_007076396.1
XR_007076397.1
NR_103731.1
NM_001278549.2 NP_001265478.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor
XM_047444738.1 XP_047300694.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X4
NM_002610.5 NP_002601.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2 precursor
XM_011511343.3 XP_011509645.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

PDK1 Protein Structure

BCDHK_Adom3

BCDHK_Adom3: Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (56 - 220)

HATPase_c

HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (269 - 390)

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  • 436 a.a.
Protein Preferred Names Protein Names

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

PDH kinase 1

mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1

pyruvate dehydrogenase kinase, isoenzyme 1

Recombinant PDK1 Proteins

Cat. No. Product Name Accession Purity
HY-P73718 PDK1 Protein, Human (sf9, His) Q15118 (S29-A436) ≥95%

Related Diseases

Diseases Alias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PDK1 VGNC VGNC:97211
Rattus norvegicus PDK1 RGD RGD:69427
Felis catus PDK1 VGNC VGNC:68775
Bos taurus PDK1 VGNC VGNC:32703
Macaca mulatta PDK1 VGNC VGNC:75932
Mus musculus PDK1 MGD MGI:1926119
Others PDK1 NCBI