2. Gene
  3. PDK1 - pyruvate dehydrogenase kinase 1 Gene

PDK1 - pyruvate dehydrogenase kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 5163 | Gene type: protein coding

About PDK1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:172,555,373-172,724,312 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 4.7), adrenal (RPKM 4.3) and 25 other tissues.

Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major Enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

PDK1 Products(36)

mRNA Protein Name
XR_427093.4
XM_047444740.1 XP_047300696.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X7
XR_007076392.1
XR_007076402.1
NR_103729.2
XR_001738771.2
XR_922944.3
XR_007076401.1
XR_007076399.1
XR_922945.1
XR_007076391.1
XR_007076400.1
XR_007076403.1
XM_006712594.3 XP_006712657.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X6
XR_922942.2
XR_007076393.1
XM_047444736.1 XP_047300692.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XM_011511344.3 XP_011509646.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XR_007076398.1
XM_047444739.1 XP_047300695.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X5
XR_001738775.3
XR_922943.2
XR_007076394.1
XM_011511347.3 XP_011509649.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XM_047444737.1 XP_047300693.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X3
XM_011511345.4 XP_011509647.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XR_007076395.1
XR_001738774.3
XR_001738772.3
XR_007076396.1
XR_007076397.1
NR_103731.1
NM_001278549.2 NP_001265478.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor
XM_047444738.1 XP_047300694.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X4
NM_002610.5 NP_002601.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2 precursor
XM_011511343.3 XP_011509645.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

PDK1 Protein Structure

BCDHK_Adom3

BCDHK_Adom3: Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (56 - 220)

HATPase_c

HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (269 - 390)

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  • 436 a.a.
Protein Preferred Names Protein Names

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

PDH kinase 1

mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1

pyruvate dehydrogenase kinase, isoenzyme 1

Recombinant PDK1 Proteins

Cat. No. Product Name Accession Purity
HY-P73718 PDK1 Protein, Human (sf9, His) Q15118 (S29-A436) ≥95%

Related Diseases

Diseases Alias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0645 Dicoumarol Inhibitor 99.59% Unkown
HY-124060 PS423 / Unkown
Pre-clinical Phase
Bioactive Molecules (39)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10514 BX795 99.84% Unkown
HY-14981 GSK2334470 Inhibitor 99.78% Unkown
HY-121744 PS10 Inhibitor 99.01% Unkown
HY-N0047 Polyphyllin I 99.89% Unkown
HY-12492 VER-246608 Inhibitor 98.92% Unkown
HY-19564 JX06 99.78% Unkown
HY-11005 BX-912 99.13% Unkown
HY-15967 PS48 Activator 99.71% Unkown
HY-124379 TPCK 98.55% Unkown
HY-10547 OSU-03012 98.88% Unkown
HY-14440 MP7 Inhibitor 99.67% Unkown
HY-N6769 Radicicol Inhibitor 99.63% Unkown
HY-121629 PS210 Activator 98.30% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-13842 BX517 Inhibitor ≥98.0% Unkown
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% Unkown
HY-114645 PDK1-IN-RS2 Inhibitor 98.50% Unkown
HY-13856 (R)-PS210 Inhibitor 98.09% Unkown
HY-157299 PDK-IN-3 Inhibitor 99.87% Unkown
HY-10515 BX-320 Inhibitor 99.4% Unkown
HY-13851 PS47 98.83% Unkown
HY-149814 PDK-IN-1 Inhibitor 99.74% Unkown
HY-129426 PDK1/Akt/Flt dual pathway inhibitor Inhibitor / Unkown
HY-117809 PDK1-IN-2 Inhibitor 98.90% Unkown
HY-151465 HIF-1α-IN-4 Inhibitor 99.95% Unkown
HY-151466 HIF-1α-IN-5 Inhibitor 99.95% Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-W070306 PDK1-IN-1 Inhibitor 99.95% Unkown
HY-W998345 SMART1 Inhibitor / Unkown
HY-135773 CRTh2 antagonist 3 / Unkown
HY-149275 PKM2/PDK1-IN-1 / Unkown
HY-156109 PDK-IN-2 / Unkown
HY-P5450 PDKtide / Unkown
HY-RS10273 PDK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10274 Pdk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10275 Pdk1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-117885 PF-5177624 Inhibitor / Unkown
HY-124288 PDK1/AurA-IN-1 / Unkown
HY-W837864 PDK1 allosteric modulator 1 / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDK1 VGNC VGNC:97211
Rattus norvegicus PDK1 RGD RGD:69427
Felis catus PDK1 VGNC VGNC:68775
Bos taurus PDK1 VGNC VGNC:32703
Macaca mulatta PDK1 VGNC VGNC:75932
Mus musculus PDK1 MGD MGI:1926119
Others PDK1 NCBI