2. Gene
  3. RASD1 - ras related dexamethasone induced 1 Gene

RASD1 - ras related dexamethasone induced 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AGS1; DEXRAS1; MGC:26290

Gene ID: 51655 | Gene type: protein coding

About RASD1

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,494,437-17,496,395 (from NCBI)

This gene has 2 transcripts (splice variants), 123 orthologues and 35 paralogues. Broad expression in fat (RPKM 57.3), kidney (RPKM 34.9) and 16 other tissues.

Summary

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

RASD1 Products(2)

mRNA Protein Name
NM_001199989.2 NP_001186918.1 dexamethasone-induced Ras-related protein 1 isoform 2
NM_016084.5 NP_057168.1 dexamethasone-induced Ras-related protein 1 isoform 1 proprotein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASD1 Protein Structure

Ras

Ras: Ras family (26 - 192)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

dexamethasone-induced Ras-related protein 1

RAS, dexamethasone-induced 1

RASD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RASD1 Q9Y272 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra RASD1 Q9Y272 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra RASD1 Q9Y272 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra RASD1 Q9Y272 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra RASD1 Q9Y272 CDR2L Homo sapiens Q86X02
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra RASD1 Q9Y272 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra RASD1 Q9Y272 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra RASD1 Q9Y272 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra RASD1 Q9Y272 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Array
32296183
Intra RASD1 Q9Y272 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 HNRNPR Homo sapiens O43390-2
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 HNRNPR Homo sapiens O43390-2
Y2H Array
32296183
Intra RASD1 Q9Y272 PRDM5 Homo sapiens Q9NQX1-2
Y2H Array
32296183
Intra RASD1 Q9Y272 PRDM5 Homo sapiens Q9NQX1-2
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra RASD1 Q9Y272 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra RASD1 Q9Y272 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Intra RASD1 Q9Y272 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
Intra RASD1 Q9Y272 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 HNRNPK Homo sapiens P61978
Y2H Prey Pooling
25416956
Intra RASD1 Q9Y272 HNRNPK Homo sapiens P61978
Validated Y2H
25416956
Intra RASD1 Q9Y272 RASAL3 Homo sapiens Q86YV0
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 RASAL3 Homo sapiens Q86YV0
Y2H Array
32296183
Intra RASD1 Q9Y272 MATR3 Homo sapiens P43243
Y2H Prey Pooling
25416956
Intra RASD1 Q9Y272 MATR3 Homo sapiens P43243
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 MATR3 Homo sapiens P43243
Y2H Array
32296183
Intra RASD1 Q9Y272 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra RASD1 Q9Y272 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra RASD1 Q9Y272 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra RASD1 Q9Y272 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra RASD1 Q9Y272 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra RASD1 Q9Y272 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra RASD1 Q9Y272 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra RASD1 Q9Y272 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra RASD1 Q9Y272 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra RASD1 Q9Y272 RBMY1F Homo sapiens Q15415
Y2H Array
25416956
Intra RASD1 Q9Y272 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Intra RASD1 Q9Y272 RBMY1F Homo sapiens Q15415
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malt Worker'S Lung

Alveolitis Due To Aspergillus Clavatus

Malt Worker Lung

Malt Workers' Lung

Malt-Workers' Lung

Malt Fever

Malt House Workers' Cough

Malt-Workers' Alveolitis

Malt-Workers' Lung Disease

Alveolitis Due To Aspergillus Fumigatus

Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Potocki-Lupski Syndrome

PTLS

Chromosome 17p11.2 Duplication Syndrome

17p11.2 Microduplication Syndrome

Duplication 17p11.2 Syndrome

Trisomy 17p11.2

Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))

17p11.2 Duplication Syndrome

Dup(17)(P11.2p11.2)

Pls

Chromosome 17, Trisomy 17p11 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11685 RASD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RASD1 VGNC VGNC:45364
Bos taurus RASD1 VGNC VGNC:33740
Mus musculus RASD1 MGD MGI:1270848
Rattus norvegicus RASD1 RGD RGD:619727
Felis catus RASD1 VGNC VGNC:64498
Macaca mulatta RASD1 VGNC VGNC:76485