VPS29 - VPS29 retromer complex component Gene

Homo sapiens

Also known as DC7; DC15; PEP11

Gene ID: 51699 | Gene type: protein coding

About VPS29

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,491,083-110,502,111 (from NCBI)

This gene has 12 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in fat (RPKM 31.1), esophagus (RPKM 28.7) and 25 other tissues.

Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]

VPS29 Products(4)

mRNA	Protein	Name
NM_001282150.2	NP_001269079.1	vacuolar protein sorting-associated protein 29 isoform 3
NM_001282151.2	NP_001269080.1	vacuolar protein sorting-associated protein 29 isoform 4
NM_016226.5	NP_057310.1	vacuolar protein sorting-associated protein 29 isoform 1
NM_057180.3	NP_476528.1	vacuolar protein sorting-associated protein 29 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11102511	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	28892079	GOA
NOT involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24603492	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11102511	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	11102511	GOA
part of retromer, cargo-selective complex	IDA IDA: Inferred from direct assay	27385586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS29 Protein Structure

Metallophos_2

0
100
182 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 29

PEP11 homolog

VPS29 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VPS29	Q9UBQ0	TBC1D5	Homo sapiens	B9A6K1	Y2H Prey Pooling	25416956
Intra	VPS29	Q9UBQ0	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	17891154
Intra	VPS29	Q9UBQ0	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	35271311
Intra	VPS29	Q9UBQ0	VPS26A	Homo sapiens	O75436	GMS	11102511
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	35271311
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	Y2H Array	25502805
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	37172566
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	ITC	24980502
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	GMS	17891154
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	Y2H Array	25416956
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	X-Ray Diffraction	17891154
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	33961781
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	LexA B52 Complement	11102511
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	17891154
Intra	VPS29	Q9UBQ0	VPS35	Homo sapiens	Q96QK1	Y2H Array	31515488
Intra	VPS29	Q9UBQ0	VPS35L	Homo sapiens	Q7Z3J2	Anti Tag CoIP	35271311
Intra	VPS29	Q9UBQ0	VPS35L	Homo sapiens	Q7Z3J2	Anti Tag CoIP	37172566
Intra	VPS29	Q9UBQ0	VPS35L	Homo sapiens	Q7Z3J2	ITC	37172566
Intra	VPS29	Q9UBQ0	VPS35L	Homo sapiens	Q7Z3J2	X-Ray Diffraction	37172566
Intra	VPS29	Q9UBQ0	VPS35L	Homo sapiens	Q7Z3J2	Anti Tag CoIP	33961781
Intra	VPS29	Q9UBQ0	VPS35L	Homo sapiens	Q7Z3J2	Pull Down	37172566
Intra	VPS29	Q9UBQ0	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	35271311
Intra	VPS29	Q9UBQ0	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	37172566
Intra	VPS29	Q9UBQ0	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	24603492
Intra	VPS29	Q9UBQ0	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ritscher-Schinzel Syndrome

3c Syndrome	Ccc Dysplasia
Craniocerebellocardiac Dysplasia	Cranio-Cerebello-Cardiac Dysplasia

Spastic Paraplegia 36, Autosomal Dominant

SPG36	Hereditary Spastic Paraplegia 36
Autosomal Dominant Spastic Paraplegia Type 36	Autosomal Dominant Spastic Paraplegia 36

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15682	VPS29 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	VPS29	VGNC	VGNC:82553
Bos taurus	VPS29	VGNC	VGNC:36816
Canis familiaris	VPS29	VGNC	VGNC:48283
Rattus norvegicus	VPS29	RGD	RGD:1308332
Macaca mulatta	VPS29	VGNC	VGNC:78956
Mus musculus	VPS29	MGD	MGI:1928344
Others	VPS29	NCBI

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