VPS26A - VPS26 retromer complex component A Gene

Homo sapiens

Also known as HB58; PEP8A; VPS26; Hbeta58

Gene ID: 9559 | Gene type: protein coding

About VPS26A

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,124,178-69,174,412 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 20.4), esophagus (RPKM 15.7) and 25 other tissues.

Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

VPS26A Products(5)

mRNA	Protein	Name
NM_001035260.3	NP_001030337.1	vacuolar protein sorting-associated protein 26A isoform 2
NM_001318944.2	NP_001305873.1	vacuolar protein sorting-associated protein 26A isoform 3
NM_001318945.2	NP_001305874.1	vacuolar protein sorting-associated protein 26A isoform 4
NM_001318946.2	NP_001305875.1	vacuolar protein sorting-associated protein 26A isoform 5
NM_004896.5	NP_004887.2	vacuolar protein sorting-associated protein 26A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11102511	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	21602791	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	15078903	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	15078903	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	22431521	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	11102511	GOA
part of retromer, cargo-selective complex	IDA IDA: Inferred from direct assay	27385586	GOA
located in tubular endosome	IDA IDA: Inferred from direct assay	15078903	GOA
located in vesicle	IDA IDA: Inferred from direct assay	20682791	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS26A Protein Structure

Vps26

0
100
200
300
327 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 26A

VPS26 retromer complex comonent A

VPS26A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VPS26A	O75436	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	28514442
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	Confocal	15078903
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	GMS	17891154
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	Anti Bait CoIP	11102511
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	GMS	11102511
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	26496610
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	CoIP	16732284
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	Validated Y2H	32296183
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	33961781
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	Pull Down	37172566
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	LexA B52 Complement	11102511
Intra	VPS26A	O75436	VPS35	Homo sapiens	Q96QK1	TEM	17891154
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	26496610
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	CoIP	16732284
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	Anti Bait CoIP	11102511
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	33961781
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	GMS	11102511
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	TEM	17891154
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	Pull Down	37172566
Intra	VPS26A	O75436	VPS29	Homo sapiens	Q9UBQ0	GMS	17891154

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ritscher-Schinzel Syndrome

3c Syndrome	Ccc Dysplasia
Craniocerebellocardiac Dysplasia	Cranio-Cerebello-Cardiac Dysplasia

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15679	VPS26A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VPS26A	MGD	MGI:1353654
Canis familiaris	VPS26A	VGNC	VGNC:48280
Felis catus	VPS26A	VGNC	VGNC:66960
Rattus norvegicus	VPS26A	RGD	RGD:1359254
Macaca mulatta	VPS26A	VGNC	VGNC:78775
Bos taurus	VPS26A	VGNC	VGNC:36814

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