PFDN2 - prefoldin subunit 2 Gene

Homo sapiens

Also known as PFD2

Gene ID: 5202 | Gene type: protein coding

About PFDN2

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,100,561-161,118,037 (from NCBI)

This gene has 2 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in fat (RPKM 33.7), brain (RPKM 30.3) and 25 other tissues.

Summary

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

PFDN2 Products(1)

mRNA	Protein	Name
NM_012394.4	NP_036526.2	prefoldin subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	23614719	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15923622	GOA
enables protein folding chaperone	IPI IPI: Inferred from physical interaction	16876117	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	30955883	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of amyloid fibril formation	IDA IDA: Inferred from direct assay	23614719	GOA
involved in positive regulation of cytoskeleton organization	IDA IDA: Inferred from direct assay	16876117	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RPAP3/R2TP/prefoldin-like complex	IPI IPI: Inferred from physical interaction	31738558	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16876117	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	17936702	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16876117	GOA
part of prefoldin complex	IDA IDA: Inferred from direct assay	23614719	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFDN2 Protein Structure

Prefoldin_2

0
100
154 a.a.

Protein Preferred Names

Protein Names

prefoldin subunit 2

prefoldin 2

PFDN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PFDN2	Q9UHV9	UQCRC1	Homo sapiens	P31930	Validated Y2H	32814053
Intra	PFDN2	Q9UHV9	UQCRC1	Homo sapiens	P31930	Y2H Array	32814053
Intra	PFDN2	Q9UHV9	UQCRC1	Homo sapiens	P31930	Y2H Pooling	32814053
Intra	PFDN2	Q9UHV9	ZNF726	Homo sapiens	A6NNF4-2	Y2H Prey Pooling	32296183
Intra	PFDN2	Q9UHV9	ZNF726	Homo sapiens	A6NNF4-2	Y2H Array	32296183
Intra	PFDN2	Q9UHV9	POLR3A	Homo sapiens	O14802	Anti Tag CoIP	33961781
Intra	PFDN2	Q9UHV9	PDRG1	Homo sapiens	Q9NUG6	Anti Tag CoIP	28514442
Intra	PFDN2	Q9UHV9	PDRG1	Homo sapiens	Q9NUG6	Lumier	25036637
Intra	PFDN2	Q9UHV9	PDRG1	Homo sapiens	Q9NUG6	Anti Tag CoIP	33961781
Intra	PFDN2	Q9UHV9	PFDN1	Homo sapiens	O60925	Anti Tag CoIP	28514442
Intra	PFDN2	Q9UHV9	PFDN1	Homo sapiens	O60925	Anti Tag CoIP	33961781
Intra	PFDN2	Q9UHV9	PFDN1	Homo sapiens	O60925	Y2H	16876117
Intra	PFDN2	Q9UHV9	RPAP3	Homo sapiens	Q9H6T3	Lumier	25036637
Intra	PFDN2	Q9UHV9	URI1	Homo sapiens	O94763	Lumier	25036637
Intra	PFDN2	Q9UHV9	URI1	Homo sapiens	O94763	Anti Tag CoIP	33961781
Intra	PFDN2	Q9UHV9	PFDN5	Homo sapiens	Q99471	Lumier	25036637
Intra	PFDN2	Q9UHV9	PFDN5	Homo sapiens	Q99471	Anti Tag CoIP	33961781
Intra	PFDN2	Q9UHV9	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	PFDN2	Q9UHV9	PFDN5	Homo sapiens	Q99471	Anti Tag CoIP	28514442
Intra	PFDN2	Q9UHV9	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	PFDN2	Q9UHV9	UXT	Homo sapiens	Q9UBK9	Anti Tag CoIP	33961781
Intra	PFDN2	Q9UHV9	UXT	Homo sapiens	Q9UBK9	Anti Tag CoIP	28514442
Intra	PFDN2	Q9UHV9	VBP1	Homo sapiens	P61758	Anti Tag CoIP	33961781
Intra	PFDN2	Q9UHV9	VBP1	Homo sapiens	P61758	Y2H Array	32296183
Intra	PFDN2	Q9UHV9	VBP1	Homo sapiens	P61758	Y2H Prey Pooling	32296183
Intra	PFDN2	Q9UHV9	VBP1	Homo sapiens	P61758	Anti Tag CoIP	28514442
Cross	PFDN2	Q9UHV9	f_hcv77	Hepatitis C virus	P0C045	Confocal	16876117
Cross	PFDN2	Q9UHV9	f_hcv77	Hepatitis C virus	P0C045	Y2H	16876117

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PFDN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71197	PFDN2 Protein, Human (His)	Q9UHV9 (M1-S154)	≥95%

Related Diseases

Diseases

Alias

Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 4	SRTD4
Atd4	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 4

Variegate Porphyria

Porphyria Variegata	Protoporphyrinogen Oxidase Deficiency
VP	Ppox Deficiency
Porphyria, South African Type	Porphyria Variegata, Susceptibility To
Protocoproporphyria	Porphyria Variegate
Porphyria South African Type	Pv
Porphyria, Variegate	Vp - [Variegate Porphyria]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10358	PFDN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PFDN2	RGD	RGD:1591406
Mus musculus	PFDN2	MGD	MGI:1276111
Bos taurus	PFDN2	VGNC	VGNC:59188
Macaca mulatta	PFDN2	VGNC	VGNC:106469
Felis catus	PFDN2	VGNC	VGNC:68802
Canis familiaris	PFDN2	VGNC	VGNC:44440
Others	PFDN2	NCBI

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