VBP1 - VHL binding protein 1 Gene

Homo sapiens

Also known as PFD3; PFDN3; VBP-1; HIBBJ46

Gene ID: 7411 | Gene type: protein coding

About VBP1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,197,007-155,239,841 (from NCBI)

This gene has 4 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in brain (RPKM 27.3), heart (RPKM 18.7) and 25 other tissues.

Summary

The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]

VBP1 Products(4)

mRNA	Protein	Name
NM_001303543.1	NP_001290472.1	prefoldin subunit 3 isoform 2
NM_001303544.1	NP_001290473.1	prefoldin subunit 3 isoform 3
NM_001303545.1	NP_001290474.1	prefoldin subunit 3 isoform 4
NM_003372.7	NP_003363.1	prefoldin subunit 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	23614719	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17698809	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	30955883	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of amyloid fibril formation	IDA IDA: Inferred from direct assay	23614719	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of prefoldin complex	IDA IDA: Inferred from direct assay	23614719	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VBP1 Protein Structure

Prefoldin

0
100
197 a.a.

Protein Preferred Names

Protein Names

prefoldin subunit 3

von Hippel-Lindau binding protein 1

VBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VBP1	P61758	SULT1B1	Homo sapiens	O43704	Validated Y2H	32814053
Intra	VBP1	P61758	SULT1B1	Homo sapiens	O43704	Y2H Pooling	32814053
Intra	VBP1	P61758	SULT1B1	Homo sapiens	O43704	Y2H Array	32814053
Intra	VBP1	P61758	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	VBP1	P61758	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	VBP1	P61758	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	VBP1	P61758	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	VBP1	P61758	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	VBP1	P61758	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	VBP1	P61758	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	VBP1	P61758	THAP3	Homo sapiens	Q8WTV1	Y2H Pooling	32814053
Intra	VBP1	P61758	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32814053
Intra	VBP1	P61758	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32814053
Intra	VBP1	P61758	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	VBP1	P61758	ZNF488	Homo sapiens	Q96MN9-2	Validated Y2H	32814053
Intra	VBP1	P61758	ZNF488	Homo sapiens	Q96MN9-2	Y2H Pooling	32814053
Intra	VBP1	P61758	ZNF488	Homo sapiens	Q96MN9-2	Y2H Array	32814053
Intra	VBP1	P61758	UBL7	Homo sapiens	Q96S82	Y2H Prey Pooling	25416956
Intra	VBP1	P61758	UBL7	Homo sapiens	Q96S82	Y2H Prey Pooling	32296183
Intra	VBP1	P61758	UBL7	Homo sapiens	Q96S82	Validated Y2H	25416956
Intra	VBP1	P61758	UBL7	Homo sapiens	Q96S82	Validated Y2H	32296183
Intra	VBP1	P61758	UBL7	Homo sapiens	Q96S82	Anti Tag CoIP	33961781
Intra	VBP1	P61758	UBL7	Homo sapiens	Q96S82	Y2H Array	32296183
Intra	VBP1	P61758	UBL7	Homo sapiens	Q96S82	Anti Tag CoIP	28514442
Intra	VBP1	P61758	PFDN4	Homo sapiens	Q9NQP4	Validated Y2H	32296183
Intra	VBP1	P61758	PFDN4	Homo sapiens	Q9NQP4	Y2H Array	32296183
Intra	VBP1	P61758	PFDN4	Homo sapiens	Q9NQP4	Y2H Prey Pooling	25416956
Intra	VBP1	P61758	PFDN4	Homo sapiens	Q9NQP4	Y2H Prey Pooling	32296183
Intra	VBP1	P61758	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	VBP1	P61758	PFDN5	Homo sapiens	Q99471	Anti Tag CoIP	33961781
Intra	VBP1	P61758	PFDN5	Homo sapiens	Q99471	Anti Tag CoIP	28514442
Intra	VBP1	P61758	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	VBP1	P61758	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	VBP1	P61758	PFDN2	Homo sapiens	Q9UHV9	Y2H Array	32814053
Intra	VBP1	P61758	PFDN2	Homo sapiens	Q9UHV9	Y2H Pooling	32814053
Intra	VBP1	P61758	PFDN2	Homo sapiens	Q9UHV9	Validated Y2H	32296183
Intra	VBP1	P61758	PFDN2	Homo sapiens	Q9UHV9	Validated Y2H	32814053
Intra	VBP1	P61758	ZNF576	Homo sapiens	Q9H609	Validated Y2H	32296183
Intra	VBP1	P61758	GABPB1	Homo sapiens	Q06547-2	Validated Y2H	32814053
Intra	VBP1	P61758	GABPB1	Homo sapiens	Q06547-2	Y2H Pooling	32814053
Intra	VBP1	P61758	GABPB1	Homo sapiens	Q06547-2	Y2H Array	32814053
Intra	VBP1	P61758	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	VBP1	P61758	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Prey Pooling	32296183
Intra	VBP1	P61758	TSC22D4	Homo sapiens	Q9Y3Q8	Validated Y2H	32296183
Intra	VBP1	P61758	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Array	32296183
Intra	VBP1	P61758	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	VBP1	P61758	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183
Intra	VBP1	P61758	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	VBP1	P61758	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	VBP1	P61758	ZNF581	Homo sapiens	Q9P0T4	Y2H Array	32814053
Intra	VBP1	P61758	ZNF581	Homo sapiens	Q9P0T4	Y2H Pooling	32814053
Intra	VBP1	P61758	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32814053
Intra	VBP1	P61758	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	VBP1	P61758	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	VBP1	P61758	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	VBP1	P61758	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32814053
Intra	VBP1	P61758	ZNF232	Homo sapiens	Q9UNY5	Y2H Pooling	32814053
Intra	VBP1	P61758	ZNF232	Homo sapiens	Q9UNY5	Y2H Array	32814053
Intra	VBP1	P61758	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	VBP1	P61758	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	VBP1	P61758	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	VBP1	P61758	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome

Mental Retardation, X-Linked, Syndromic 32

Mrxs32

Non-Syndromic X-Linked Intellectual Disability 72

Mrx72

Hypomelanosis Of Ito

Incontinentia Pigmenti Achromians	Nevus Of Ito
Ipa	Ito Hypomelanosis
Ito	Pigmentation Disorders
HMI	Incontinentia Pigmenti, Type I, Formerly
Ip1, Formerly	Bloch-Siemans Syndrome
Incontinentia Pigmenti Achromians Syndrome	Ito'S Nevus
Incontinentia Pigmenti Type 1	Nevi Of Ito
Nevus Fuscocaeruleus Acromiodeltoideus	Bloch Sulzberger Syndrome
Skin Pigmentation Disorder

Schimmelpenning-Feuerstein-Mims Syndrome

Nevus Sebaceus Of Jadassohn	Organoid Nevus Phakomatosis
Linear Nevus Sebaceous Syndrome	Sfm Syndrome
Jadassohn Nevus Phakomatosis	Jnp
Schimmelpenning Syndrome	Solomon Syndrome
SFM	Linear Sebaceous Nevus Syndrome
Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic	Nevus Sebaceus Syndrome
Organoid Nevus Syndrome	Schimmelpenning Feuerstein Mims Syndrome
Sebaceous Nevus Syndrome, Linear	Epidermal Nevus Syndrome, Formerly
Sebaceous Nevus Syndrome Linear	Linear Nevus Sebaceus Syndrome
Epidermal Nevus Syndrome	Ss
Nevus Sebaceous

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15617	VBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VBP1	VGNC	VGNC:36777
Mus musculus	VBP1	MGD	MGI:1333804
Rattus norvegicus	VBP1	RGD	RGD:1590535
Canis familiaris	VBP1	VGNC	VGNC:48239
Felis catus	VBP1	VGNC	VGNC:66929

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