2. Gene
  3. VBP1 - VHL binding protein 1 Gene

VBP1 - VHL binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PFD3; PFDN3; VBP-1; HIBBJ46

Gene ID: 7411 | Gene type: protein coding

About VBP1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,197,007-155,239,841 (from NCBI)

This gene has 4 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in brain (RPKM 27.3), heart (RPKM 18.7) and 25 other tissues.

Summary

The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]

VBP1 Products(4)

mRNA Protein Name
NM_001303543.1 NP_001290472.1 prefoldin subunit 3 isoform 2
NM_001303544.1 NP_001290473.1 prefoldin subunit 3 isoform 3
NM_001303545.1 NP_001290474.1 prefoldin subunit 3 isoform 4
NM_003372.7 NP_003363.1 prefoldin subunit 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
23614719 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17698809 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
30955883 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of amyloid fibril formation IDA
IDA: Inferred from direct assay
23614719 GOA
involved in protein folding IDA
IDA: Inferred from direct assay
30955883 GOA
Cellular Component GO Annotation Evidence Reference Source
part of prefoldin complex IDA
IDA: Inferred from direct assay
23614719 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VBP1 Protein Structure

Prefoldin

Prefoldin: Prefoldin subunit (60 - 182)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

prefoldin subunit 3

von Hippel-Lindau binding protein 1

VBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra VBP1 P61758 SULT1B1 Homo sapiens O43704
Validated Y2H
32814053
Intra VBP1 P61758 SULT1B1 Homo sapiens O43704
Y2H Pooling
32814053
Intra VBP1 P61758 SULT1B1 Homo sapiens O43704
Y2H Array
32814053
Intra VBP1 P61758 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra VBP1 P61758 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra VBP1 P61758 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra VBP1 P61758 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
Intra VBP1 P61758 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra VBP1 P61758 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra VBP1 P61758 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra VBP1 P61758 THAP3 Homo sapiens Q8WTV1
Y2H Pooling
32814053
Intra VBP1 P61758 THAP3 Homo sapiens Q8WTV1
Validated Y2H
32814053
Intra VBP1 P61758 THAP3 Homo sapiens Q8WTV1
Y2H Array
32814053
Intra VBP1 P61758 MISP Homo sapiens Q8IVT2
Validated Y2H
32296183
Intra VBP1 P61758 ZNF488 Homo sapiens Q96MN9-2
Validated Y2H
32814053
Intra VBP1 P61758 ZNF488 Homo sapiens Q96MN9-2
Y2H Pooling
32814053
Intra VBP1 P61758 ZNF488 Homo sapiens Q96MN9-2
Y2H Array
32814053
Intra VBP1 P61758 UBL7 Homo sapiens Q96S82
Y2H Prey Pooling
25416956
Intra VBP1 P61758 UBL7 Homo sapiens Q96S82
Y2H Prey Pooling
32296183
Intra VBP1 P61758 UBL7 Homo sapiens Q96S82
Validated Y2H
25416956
Intra VBP1 P61758 UBL7 Homo sapiens Q96S82
Validated Y2H
32296183
Intra VBP1 P61758 UBL7 Homo sapiens Q96S82
Anti Tag CoIP
33961781
Intra VBP1 P61758 UBL7 Homo sapiens Q96S82
Y2H Array
32296183
Intra VBP1 P61758 UBL7 Homo sapiens Q96S82
Anti Tag CoIP
28514442
Intra VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Validated Y2H
32296183
Intra VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Y2H Array
32296183
Intra VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Y2H Prey Pooling
25416956
Intra VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Y2H Prey Pooling
32296183
Intra VBP1 P61758 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra VBP1 P61758 PFDN5 Homo sapiens Q99471
Anti Tag CoIP
33961781
Intra VBP1 P61758 PFDN5 Homo sapiens Q99471
Anti Tag CoIP
28514442
Intra VBP1 P61758 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra VBP1 P61758 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Y2H Array
32814053
Intra VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Y2H Pooling
32814053
Intra VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Validated Y2H
32296183
Intra VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Validated Y2H
32814053
Intra VBP1 P61758 ZNF576 Homo sapiens Q9H609
Validated Y2H
32296183
Intra VBP1 P61758 GABPB1 Homo sapiens Q06547-2
Validated Y2H
32814053
Intra VBP1 P61758 GABPB1 Homo sapiens Q06547-2
Y2H Pooling
32814053
Intra VBP1 P61758 GABPB1 Homo sapiens Q06547-2
Y2H Array
32814053
Intra VBP1 P61758 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
Intra VBP1 P61758 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
32296183
Intra VBP1 P61758 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
32296183
Intra VBP1 P61758 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
32296183
Intra VBP1 P61758 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra VBP1 P61758 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
32296183
Intra VBP1 P61758 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra VBP1 P61758 MYOZ1 Homo sapiens Q9NP98
Validated Y2H
32296183
Intra VBP1 P61758 ZNF581 Homo sapiens Q9P0T4
Y2H Array
32814053
Intra VBP1 P61758 ZNF581 Homo sapiens Q9P0T4
Y2H Pooling
32814053
Intra VBP1 P61758 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32814053
Intra VBP1 P61758 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra VBP1 P61758 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra VBP1 P61758 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra VBP1 P61758 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32814053
Intra VBP1 P61758 ZNF232 Homo sapiens Q9UNY5
Y2H Pooling
32814053
Intra VBP1 P61758 ZNF232 Homo sapiens Q9UNY5
Y2H Array
32814053
Intra VBP1 P61758 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra VBP1 P61758 BECN1 Homo sapiens Q14457
Validated Y2H
32814053
Intra VBP1 P61758 BECN1 Homo sapiens Q14457
Y2H Array
32814053
Intra VBP1 P61758 BECN1 Homo sapiens Q14457
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome

Mental Retardation, X-Linked, Syndromic 32

Mrxs32
Non-Syndromic X-Linked Intellectual Disability 72

Mrx72
Hypomelanosis Of Ito

Incontinentia Pigmenti Achromians

Nevus Of Ito

Ipa

Ito Hypomelanosis

Ito

Pigmentation Disorders

HMI

Incontinentia Pigmenti, Type I, Formerly

Ip1, Formerly

Bloch-Siemans Syndrome

Incontinentia Pigmenti Achromians Syndrome

Ito'S Nevus

Incontinentia Pigmenti Type 1

Nevi Of Ito

Nevus Fuscocaeruleus Acromiodeltoideus

Bloch Sulzberger Syndrome

Skin Pigmentation Disorder
Schimmelpenning-Feuerstein-Mims Syndrome

Nevus Sebaceus Of Jadassohn

Organoid Nevus Phakomatosis

Linear Nevus Sebaceous Syndrome

Sfm Syndrome

Jadassohn Nevus Phakomatosis

Jnp

Schimmelpenning Syndrome

Solomon Syndrome

SFM

Linear Sebaceous Nevus Syndrome

Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic

Nevus Sebaceus Syndrome

Organoid Nevus Syndrome

Schimmelpenning Feuerstein Mims Syndrome

Sebaceous Nevus Syndrome, Linear

Epidermal Nevus Syndrome, Formerly

Sebaceous Nevus Syndrome Linear

Linear Nevus Sebaceus Syndrome

Epidermal Nevus Syndrome

Ss

Nevus Sebaceous
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15617 VBP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VBP1 VGNC VGNC:36777
Mus musculus VBP1 MGD MGI:1333804
Rattus norvegicus VBP1 RGD RGD:1590535
Canis familiaris VBP1 VGNC VGNC:48239
Felis catus VBP1 VGNC VGNC:66929