MBD3 - methyl-CpG binding domain protein 3 Gene

Homo sapiens

Gene ID: 53615 | Gene type: protein coding

About MBD3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,573,596-1,592,865 (from NCBI)

This gene has 11 transcripts (splice variants), 234 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 23.4), fat (RPKM 18.3) and 25 other tissues.

Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the Other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

MBD3 Products(2)

mRNA	Protein	Name
NM_001281453.2	NP_001268382.1	methyl-CpG-binding domain protein 3 isoform 1
NM_001281454.2	NP_001268383.1	methyl-CpG-binding domain protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	24307175	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12183469	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	33283408	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15701600	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MBD3 Protein Structure

MBD

MBD_C

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

methyl-CpG-binding domain protein 3

MBD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MBD3	O95983	ZNF277	Homo sapiens	Q8WWA6	Y2H Prey Pooling	25416956
Intra	MBD3	O95983	ZNF277	Homo sapiens	Q8WWA6	Validated Y2H	25416956
Intra	MBD3	O95983	ZNF277	Homo sapiens	Q8WWA6	Y2H Array	25416956
Intra	MBD3	O95983	ICA1	Homo sapiens	Q05084	Validated Y2H	25416956
Intra	MBD3	O95983	ICA1	Homo sapiens	Q05084	Y2H Array	25416956
Intra	MBD3	O95983	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	MBD3	O95983	HDAC1	Homo sapiens	Q13547	Pull Down	25123934
Intra	MBD3	O95983	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	24048479
Intra	MBD3	O95983	HDAC1	Homo sapiens	Q13547	Crosslink	25123934
Intra	MBD3	O95983	MYC	Homo sapiens	P01106	Anti Tag CoIP	24048479
Intra	MBD3	O95983	POU5F1	Homo sapiens	Q01860	Anti Tag CoIP	24048479
Intra	MBD3	O95983	SOX2	Homo sapiens	P48431	Anti Tag CoIP	24048479
Intra	MBD3	O95983	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	MBD3	O95983	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	MBD3	O95983	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MBD3	O95983	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	MBD3	O95983	KLF4	Homo sapiens	O43474	Anti Tag CoIP	24048479
Intra	MBD3	O95983	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	MBD3	O95983	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	MBD3	O95983	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	MBD3	O95983	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	25416956
Intra	MBD3	O95983	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	25416956
Intra	MBD3	O95983	CEP76	Homo sapiens	Q8TAP6	Y2H Array	25416956
Intra	MBD3	O95983	RCN3	Homo sapiens	Q96D15	Y2H Prey Pooling	25416956
Intra	MBD3	O95983	RCN3	Homo sapiens	Q96D15	Validated Y2H	25416956
Intra	MBD3	O95983	RCN3	Homo sapiens	Q96D15	Y2H Array	25416956
Intra	MBD3	O95983	GATAD2B	Homo sapiens	Q8WXI9	Validated Y2H	25416956
Intra	MBD3	O95983	GATAD2B	Homo sapiens	Q8WXI9	Pull Down	25123934
Intra	MBD3	O95983	GATAD2B	Homo sapiens	Q8WXI9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08183	MBD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99506	Tamrintamab		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MBD3	VGNC	VGNC:31274
Canis familiaris	MBD3	VGNC	VGNC:43050
Macaca mulatta	MBD3	VGNC	VGNC:81470
Rattus norvegicus	MBD3	RGD	RGD:1307389
Felis catus	MBD3	VGNC	VGNC:68199
Mus musculus	MBD3	MGD	MGI:1333812

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