PPP2CB - protein phosphatase 2 catalytic subunit beta Gene

Homo sapiens

Also known as PP2CB; PP2Abeta

Gene ID: 5516 | Gene type: protein coding

About PPP2CB

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,785,616-30,812,818 (from NCBI)

This gene has 10 transcripts (splice variants), 150 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 83.4), thyroid (RPKM 78.1) and 24 other tissues.

Summary

This gene encodes the Phosphatase 2A catalytic subunit. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

PPP2CB Products(1)

mRNA	Protein	Name
NM_001009552.2	NP_001009552.1	serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647778	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of NF-kappaB transcription factor activity	IGI IGI: Inferred from genetic interaction	28159925	GOA
acts upstream of negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	28159925	GOA
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28159925	GOA
acts upstream of negative regulation of tumor necrosis factor-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	28159925	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2CB Protein Structure

Metallophos

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

PP2A-beta

PPP2CB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2CB	P62714	TIPRL	Homo sapiens	O75663	Anti Tag CoIP	27880917
Intra	PPP2CB	P62714	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	27880917
Intra	PPP2CB	P62714	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	26496610
Intra	PPP2CB	P62714	IGBP1	Homo sapiens	P78318	Y2H	9647778
Intra	PPP2CB	P62714	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	35271311
Intra	PPP2CB	P62714	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	33961781
Intra	PPP2CB	P62714	IGBP1	Homo sapiens	P78318	TAP	18782753
Intra	PPP2CB	P62714	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	19156129
Intra	PPP2CB	P62714	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	35271311
Intra	PPP2CB	P62714	STRIP1	Homo sapiens	Q5VSL9	TAP	18782753
Intra	PPP2CB	P62714	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	33961781
Intra	PPP2CB	P62714	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	26496610
Intra	PPP2CB	P62714	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	28514442
Intra	PPP2CB	P62714	AXIN2	Homo sapiens	Q9Y2T1	Pull Down	10698523
Intra	PPP2CB	P62714	q13642-2	Homo sapiens	Q13642-2	Anti Bait CoIP	20969868
Intra	PPP2CB	P62714	q13642-2	Homo sapiens	Q13642-2	Y2H	20969868

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11008	PPP2CB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PPP2CB	VGNC	VGNC:44904
Felis catus	PPP2CB	VGNC	VGNC:107425
Macaca mulatta	PPP2CB	VGNC	VGNC:76373
Rattus norvegicus	PPP2CB	RGD	RGD:3381
Bos taurus	PPP2CB	VGNC	VGNC:33252
Mus musculus	PPP2CB	MGD	MGI:1321161

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