2. Gene
  3. STRIP1 - striatin interacting protein 1 Gene

STRIP1 - striatin interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FAM40A; FAR11A

Gene ID: 85369 | Gene type: protein coding

About STRIP1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,031,577-110,054,641 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.7), bone marrow (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a member of the striatin-interacting Phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

STRIP1 Products(2)

mRNA Protein Name
NM_001270768.2 NP_001257697.1 striatin-interacting protein 1 isoform 2
NM_033088.4 NP_149079.2 striatin-interacting protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
30622739 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cortical actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
30622739 GOA
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
21834987 GOA
Cellular Component GO Annotation Evidence Reference Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15302935 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRIP1 Protein Structure

N1221

N1221: N1221-like protein (66 - 347)

DUF3402

DUF3402: Domain of unknown function (DUF3402) (420 - 808)

  • 0
  • 200
  • 400
  • 600
  • 837 a.a.
Protein Preferred Names Protein Names

striatin-interacting protein 1

FAR11 factor arrest 11 homolog A

STRIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STRIP1 Q5VSL9 PPP2CB Homo sapiens P62714
Anti Tag CoIP
33961781
Intra
STRIP1 Q5VSL9 PPP2CB Homo sapiens P62714
Anti Tag CoIP
25531779
Intra
STRIP1 Q5VSL9 PPP2CB Homo sapiens P62714
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
33961781
Intra
STRIP1 Q5VSL9 STK26 Homo sapiens Q9P289
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 PPP2CA Homo sapiens P67775
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 PPP2CA Homo sapiens P67775
Anti Tag CoIP
33961781
Intra
STRIP1 Q5VSL9 PPP2CA Homo sapiens P67775
Anti Tag CoIP
25531779
Intra
STRIP1 Q5VSL9 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
25531779
Intra
STRIP1 Q5VSL9 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 TRAF3IP3 Homo sapiens Q9Y228
Anti Tag CoIP
18782753
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3
Root Caries

Cementum Caries

Dental Caries Of Root Surface
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N10881 Dihydrocurcumenone / Unkown
HY-RS13964 STRIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STRIP1 MGD MGI:2443884
Canis familiaris STRIP1 VGNC VGNC:46943
Rattus norvegicus STRIP1 RGD RGD:1564249
Macaca mulatta STRIP1 VGNC VGNC:78217
Bos taurus STRIP1 VGNC VGNC:35422
Felis catus STRIP1 VGNC VGNC:65801