IMP3 - IMP U3 small nucleolar ribonucleoprotein 3 Gene

Homo sapiens

Also known as BRMS2; MRPS4; C15orf12

Gene ID: 55272 | Gene type: protein coding

About IMP3

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,639,093-75,640,224 (from NCBI)

This gene has 3 transcripts (splice variants) and 184 orthologues.

Summary

This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]

IMP3 Products(1)

mRNA	Protein	Name
NM_018285.4	NP_060755.1	U3 small nucleolar ribonucleoprotein protein IMP3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12655004	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Mpp10 complex	IDA IDA: Inferred from direct assay	12655004	GOA
part of Mpp10 complex	IPI IPI: Inferred from physical interaction	12655004	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12655004	GOA
part of preribosome	IDA IDA: Inferred from direct assay	12655004	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMP3 Protein Structure

0
100
184 a.a.

Protein Preferred Names

Protein Names

U3 small nucleolar ribonucleoprotein protein IMP3

IMP3, U3 small nucleolar ribonucleoprotein, homolog

IMP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IMP3	Q9NV31	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	IMP3	Q9NV31	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	IMP3	Q9NV31	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	IMP3	Q9NV31	NANOS3	Homo sapiens	P60323-2	Y2H Array	32296183
Intra	IMP3	Q9NV31	NANOS3	Homo sapiens	P60323-2	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	MCC	Homo sapiens	P23508	Anti Tag CoIP	33961781
Intra	IMP3	Q9NV31	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	IMP3	Q9NV31	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	ZYX	Homo sapiens	Q15942	Y2H Array	31515488
Intra	IMP3	Q9NV31	ZYX	Homo sapiens	Q15942	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	ZYX	Homo sapiens	Q15942	Y2H Prey Pooling	25416956
Intra	IMP3	Q9NV31	ZYX	Homo sapiens	Q15942	Y2H Array	32296183
Intra	IMP3	Q9NV31	ZYX	Homo sapiens	Q15942	Y2H Array	29892012
Intra	IMP3	Q9NV31	MPHOSPH10	Homo sapiens	O00566	Anti Tag CoIP	35271311
Intra	IMP3	Q9NV31	MPHOSPH10	Homo sapiens	O00566	Pull Down	12655004
Intra	IMP3	Q9NV31	MPHOSPH10	Homo sapiens	O00566	Anti Tag CoIP	33961781
Intra	IMP3	Q9NV31	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	IMP3	Q9NV31	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Array	32296183
Intra	IMP3	Q9NV31	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	IMP3	Q9NV31	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	IMP3	Q9NV31	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	IMP3	Q9NV31	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	IMP3	Q9NV31	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	IMP3	Q9NV31	CCNDBP1	Homo sapiens	O95273	Y2H Array	31515488
Intra	IMP3	Q9NV31	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	IMP3	Q9NV31	CCNDBP1	Homo sapiens	O95273	Y2H Array	19060904
Intra	IMP3	Q9NV31	CCNDBP1	Homo sapiens	O95273	Y2H Pooling	19060904
Intra	IMP3	Q9NV31	EVI5	Homo sapiens	O60447	Y2H Prey Pooling	32296183
Intra	IMP3	Q9NV31	EVI5	Homo sapiens	O60447	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dermatosis Papulosa Nigra

Melanoacanthoma

Animal Phobia

Zoophobia

Fear Of Animals

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06793	IMP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IMP3	VGNC	VGNC:42006
Macaca mulatta	IMP3	VGNC	VGNC:73594
Mus musculus	IMP3	MGD	MGI:1916119
Bos taurus	IMP3	VGNC	VGNC:30182
Rattus norvegicus	IMP3	RGD	RGD:1306825
Others	IMP3	NCBI

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