PPP5C - protein phosphatase 5 catalytic subunit Gene

Homo sapiens

Also known as PP5; PPT; PPP5

Gene ID: 5536 | Gene type: protein coding

About PPP5C

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,347,087-46,390,975 (from NCBI)

This gene has 15 transcripts (splice variants), 197 orthologues and 12 paralogues. Ubiquitous expression in heart (RPKM 18.5), brain (RPKM 17.4) and 25 other tissues.

Summary

This gene encodes a serine/threonine Phosphatase which is a member of the protein Phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to Hormones or cellular stress, and elevated levels of this protein may be associated with breast Cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

PPP5C Products(2)

mRNA	Protein	Name
NM_001204284.2	NP_001191213.1	serine/threonine-protein phosphatase 5 isoform 2
NM_006247.4	NP_006238.1	serine/threonine-protein phosphatase 5 isoform 1

PPP5C Protein Structure

TPR_11

TPR_1

PPP5

Metallophos

0
100
200
300
400
499 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 5

PP-T

PPP5C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP5C	P53041	STIP1	Homo sapiens	P31948	Anti Tag CoIP	21360678
Intra	PPP5C	P53041	STIP1	Homo sapiens	P31948	Pull Down	28330616
Intra	PPP5C	P53041	STIP1	Homo sapiens	P31948	Anti Tag CoIP	28330616
Intra	PPP5C	P53041	NOL9	Homo sapiens	Q5SY16	Pull Down	28330616
Intra	PPP5C	P53041	NOL9	Homo sapiens	Q5SY16	Anti Tag CoIP	28330616
Intra	PPP5C	P53041	CDK9	Homo sapiens	P50750	BioID	28330616
Intra	PPP5C	P53041	CDK9	Homo sapiens	P50750	Pull Down	28330616
Intra	PPP5C	P53041	CDK9	Homo sapiens	P50750	Anti Tag CoIP	28330616
Intra	PPP5C	P53041	CRY2	Homo sapiens	Q49AN0	Anti Tag CoIP	16790549
Intra	PPP5C	P53041	AGO3	Homo sapiens	Q9H9G7	Anti Tag CoIP	28330616
Intra	PPP5C	P53041	AGO3	Homo sapiens	Q9H9G7	Pull Down	28330616
Intra	PPP5C	P53041	CDC37	Homo sapiens	Q16543	Pull Down	28330616
Intra	PPP5C	P53041	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	25036637
Intra	PPP5C	P53041	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	21360678
Intra	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	26496610
Intra	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	21360678
Intra	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	BioID	28330616
Intra	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Pull Down	28330616
Intra	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	27880917
Intra	PPP5C	P53041	PPP2R1A	Homo sapiens	P30153	CoIP	11504734
Intra	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	27880917
Intra	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	BioID	28330616
Intra	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	NMR	16531226
Intra	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Pull Down	28330616
Intra	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	26496610
Intra	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	21360678
Intra	PPP5C	P53041	AGO1	Homo sapiens	Q9UL18	Pull Down	28330616
Intra	PPP5C	P53041	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	28330616
Intra	PPP5C	P53041	PTGES3	Homo sapiens	Q15185	Anti Tag CoIP	25036637
Intra	PPP5C	P53041	PTGES3	Homo sapiens	Q15185	Pull Down	28330616
Intra	PPP5C	P53041	ESR1	Homo sapiens	P03372	Pull Down	14764652
Intra	PPP5C	P53041	ESR1	Homo sapiens	P03372	Anti Bait CoIP	14764652
Intra	PPP5C	P53041	ESR2	Homo sapiens	Q92731	Y2H	14764652

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly, Seizures, And Developmental Delay

MCSZ	Developmental And Epileptic Encephalopathy 10
Epileptic Encephalopathy, Early Infantile, 10	Eiee10
Dee10	Early Infantile Epileptic Encephalopathy 10

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11032	PPP5C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP5C	VGNC	VGNC:33272
Canis familiaris	PPP5C	VGNC	VGNC:49945
Rattus norvegicus	PPP5C	RGD	RGD:68415
Macaca mulatta	PPP5C	VGNC	VGNC:76385
Mus musculus	PPP5C	MGD	MGI:102666
Felis catus	PPP5C	VGNC	VGNC:69024

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