CRY2 - cryptochrome circadian regulator 2 Gene

Homo sapiens

Also known as HCRY2; PHLL2

Gene ID: 1408 | Gene type: protein coding

About CRY2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,847,118-45,883,244 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 24.1), brain (RPKM 22.3) and 25 other tissues.

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CRY2 Products(2)

mRNA	Protein	Name
NM_001127457.3	NP_001120929.1	cryptochrome-2 isoform 2
NM_021117.5	NP_066940.3	cryptochrome-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables DNA (6-4) photolyase activity	IDA IDA: Inferred from direct assay	8909283	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	12627958	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	12627958	GOA
NOT enables deoxyribodipyrimidine photo-lyase activity	IDA IDA: Inferred from direct assay	8909283	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	9383998	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9383998	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	12627958	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12397359	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12397359	GOA
NOT involved in photoreactive repair	IDA IDA: Inferred from direct assay	12627958	GOA
acts upstream of or within regulation of sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	9753616	GOA
involved in response to light stimulus	IMP IMP: Inferred from mutant phenotype	15751956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	9753616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRY2 Protein Structure

DNA_photolyase

FAD_binding_7

0
100
200
300
400
500
614 a.a.

Protein Preferred Names

Protein Names

cryptochrome-2

cryptochrome 2 (photolyase-like)

CRY2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CRY2	Q49AN0	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	CTBP1	Homo sapiens	Q13363-2	Validated Y2H	25416956
Intra	CRY2	Q49AN0	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	32296183
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083-2	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	CRY2	Q49AN0	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-2	Homo sapiens	Q701N4	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-4	Homo sapiens	Q6L8H1	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-4	Homo sapiens	Q6L8H1	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-4	Homo sapiens	Q6L8H1	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-1	Homo sapiens	Q6L8H4	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	CRY2	Q49AN0	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	CRY2	Q49AN0	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	CRY2	Q49AN0	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	CRY2	Q49AN0	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	CRY2	Q49AN0	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	XRN2	Homo sapiens	Q9H0D6	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	XRN2	Homo sapiens	Q9H0D6	Y2H Array	32296183
Intra	CRY2	Q49AN0	XRN2	Homo sapiens	Q9H0D6	Validated Y2H	32296183
Intra	CRY2	Q49AN0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CRY2	Q49AN0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KLHL6	Homo sapiens	Q8WZ60	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KLHL6	Homo sapiens	Q8WZ60	Y2H Array	32296183
Intra	CRY2	Q49AN0	KLHL6	Homo sapiens	Q8WZ60	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	PPP5C	Homo sapiens	P53041	Anti Tag CoIP	16790549
Intra	CRY2	Q49AN0	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	CRY2	Q49AN0	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083	Y2H Array	25416956
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083	Y2H Prey Pooling	25416956
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	CRY2	Q49AN0	NADK	Homo sapiens	O95544	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	NADK	Homo sapiens	O95544	Y2H Array	32296183
Intra	CRY2	Q49AN0	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	CRY2	Q49AN0	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	CRY2	Q49AN0	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	CRY2	Q49AN0	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CRY2	Q49AN0	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Dysthymic Disorder

Dysthymia	Chronic Depressive Disorder
Chronic Depression	Depressive Personality
Depressive Personality Disorder	Persistent Depressive Disorder
Persistent Depression

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0318	Metronidazole		99.92%	Yes
HY-B0318A	Metronidazole hydrochloride		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108468	KL001		99.68%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115672	KS15		99.40%	Unkown
HY-134194	KL201		98.15%	Unkown
HY-RS03205	CRY2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRY2	VGNC	VGNC:27731
Canis familiaris	CRY2	VGNC	VGNC:39634
Mus musculus	CRY2	MGD	MGI:1270859
Felis catus	CRY2	VGNC	VGNC:61196
Rattus norvegicus	CRY2	RGD	RGD:620935
Macaca mulatta	CRY2	VGNC	VGNC:71500

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