1. Gene
  2. NXT2 - nuclear transport factor 2 like export factor 2 Gene

NXT2 - nuclear transport factor 2 like export factor 2 Gene

Homo sapiens

Also known as P15-2

Gene ID: 55916 | Gene type: protein coding

About NXT2

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:109,535,824-109,544,698 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.8), bone marrow (RPKM 5.3) and 23 other tissues.

Summary

The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]

NXT2 Products(3)

mRNA Protein Name
NM_001242617.2 NP_001229546.1 NTF2-related export protein 2 isoform 2
NM_001242618.2 NP_001229547.1 NTF2-related export protein 2 isoform 3
NM_018698.5 NP_061168.2 NTF2-related export protein 2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
part of nuclear RNA export factor complex IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXT2 Protein Structure

NTF2

NTF2: Nuclear transport factor 2 (NTF2) domain (18 - 136)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

NTF2-related export protein 2

protein p15-2

NXT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NXT2 Q9NPJ8 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
Intra
NXT2 Q9NPJ8 HEL-S-30 Homo sapiens V9HWB8
Y2H Array
25416956
Intra
NXT2 Q9NPJ8 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
25416956
Intra
NXT2 Q9NPJ8 SSBP3 Homo sapiens Q9BWW4
Validated Y2H
25416956
Intra
NXT2 Q9NPJ8 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
NXT2 Q9NPJ8 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
NXT2 Q9NPJ8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
NXT2 Q9NPJ8 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
NXT2 Q9NPJ8 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
NXT2 Q9NPJ8 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
NXT2 Q9NPJ8 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
NXT2 Q9NPJ8 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
NXT2 Q9NPJ8 CEP63 Homo sapiens Q96MT8
Y2H Prey Pooling
25416956
Intra
NXT2 Q9NPJ8 CEP63 Homo sapiens Q96MT8
Validated Y2H
25416956
Intra
NXT2 Q9NPJ8 NXF3 Homo sapiens Q9H4D5
Y2H Array
25416956
Intra
NXT2 Q9NPJ8 NXF3 Homo sapiens Q9H4D5
Y2H Pooling
16189514
Intra
NXT2 Q9NPJ8 NXF3 Homo sapiens Q9H4D5
Y2H Array
31515488
Intra
NXT2 Q9NPJ8 NXF3 Homo sapiens Q9H4D5
Validated Y2H
25416956
Intra
NXT2 Q9NPJ8 USP54 Homo sapiens Q70EL1
Y2H Array
25416956
Intra
NXT2 Q9NPJ8 USP54 Homo sapiens Q70EL1
Y2H Prey Pooling
25416956
Intra
NXT2 Q9NPJ8 USP54 Homo sapiens Q70EL1
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

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Orthologs Information

Species Symbol Source ID
Macaca mulatta NXT2 VGNC VGNC:75430
Mus musculus NXT2 MGD MGI:2147914
Rattus norvegicus NXT2 RGD RGD:1560204
Bos taurus NXT2 VGNC VGNC:32385
Canis familiaris NXT2 VGNC VGNC:44080