NXF3 - nuclear RNA export factor 3 Gene

Homo sapiens

Gene ID: 56000 | Gene type: protein coding

About NXF3

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:103,075,810-103,093,143 (from NCBI)

This gene has 7 transcripts (splice variants), 247 orthologues and 3 paralogues. Biased expression in testis (RPKM 42.7), gall bladder (RPKM 7.2) and 1 other tissue.

Summary

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]

NXF3 Products(1)

mRNA	Protein	Name
NM_022052.2	NP_071335.1	nuclear RNA export factor 3

NXF3 Protein Structure

Tap-RNA_bind

NTF2

0
100
200
300
400
500
531 a.a.

Protein Preferred Names

Protein Names

nuclear RNA export factor 3

TAP-like protein 3

NXF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NXF3	Q9H4D5	NXT2	Homo sapiens	Q9NPJ8-3	Complementation	32296183
Intra	NXF3	Q9H4D5	NXT2	Homo sapiens	Q9NPJ8-3	Validated Y2H	32296183
Intra	NXF3	Q9H4D5	NXT2	Homo sapiens	Q9NPJ8-3	MAPPIT	32296183
Intra	NXF3	Q9H4D5	SKIL	Homo sapiens	P12757	Validated Y2H	25416956
Intra	NXF3	Q9H4D5	SKIL	Homo sapiens	P12757	Y2H Prey Pooling	25416956
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Validated Y2H	32296183
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Y2H Array	25416956
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Anti Tag CoIP	33961781
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Complementation	32296183
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Y2H Array	32296183
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Y2H Prey Pooling	25416956
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	MAPPIT	32296183
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Y2H Prey Pooling	32296183
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Y2H Pooling	19060904
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Validated Y2H	25416956
Intra	NXF3	Q9H4D5	NXT1	Homo sapiens	Q9UKK6	Y2H Array	19060904
Intra	NXF3	Q9H4D5	NXT2	Homo sapiens	Q9NPJ8	Anti Tag CoIP	33961781
Intra	NXF3	Q9H4D5	NXT2	Homo sapiens	Q9NPJ8	Y2H Prey Pooling	25416956
Intra	NXF3	Q9H4D5	NXT2	Homo sapiens	Q9NPJ8	Y2H	21516116
Intra	NXF3	Q9H4D5	NXT2	Homo sapiens	Q9NPJ8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anterior Horn Cell Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09712	NXF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NXF3	VGNC	VGNC:75566
Canis familiaris	NXF3	VGNC	VGNC:44072
Rattus norvegicus	NXF3	RGD	RGD:1564923
Mus musculus	NXF3	MGD	MGI:2685230

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