MAP3K3 - mitogen-activated protein kinase kinase kinase 3 Gene

Homo sapiens

Also known as MEKK3; MAPKKK3

Gene ID: 4215 | Gene type: protein coding

About MAP3K3

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,622,417-63,696,305 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 15.4), lung (RPKM 14.5) and 25 other tissues.

Summary

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

MAP3K3 Products(4)

mRNA	Protein	Name
NM_001330431.2	NP_001317360.1	mitogen-activated protein kinase kinase kinase 3 isoform 3
NM_001363768.2	NP_001350697.1	mitogen-activated protein kinase kinase kinase 3 isoform 4
NM_002401.5	NP_002392.2	mitogen-activated protein kinase kinase kinase 3 isoform 2
NM_203351.3	NP_976226.1	mitogen-activated protein kinase kinase kinase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12392720	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	15001576	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	15001576	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	15001576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K3 Protein Structure

PB1

Pkinase

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 3

MAP/ERK kinase kinase 3

MAP3K3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K3	Q99759	YWHAH	Homo sapiens	Q04917	TAP	14743216
Intra	MAP3K3	Q99759	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
Intra	MAP3K3	Q99759	MAP2K5	Homo sapiens	Q13163	Pull Down	32707033
Intra	MAP3K3	Q99759	MAP2K5	Homo sapiens	Q13163	PLA	25241761
Intra	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	Imaging	14743216
Intra	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	Anti Tag CoIP	14743216
Intra	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	TAP	14743216
Intra	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	Pull Down	32707033
Intra	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	CoIP	15001576
Intra	MAP3K3	Q99759	YWHAZ	Homo sapiens	P63104	TAP	14743216
Intra	MAP3K3	Q99759	YWHAE	Homo sapiens	P62258	TAP	14743216
Intra	MAP3K3	Q99759	YWHAE	Homo sapiens	P62258	CoIP	12392720
Intra	MAP3K3	Q99759	YWHAE	Homo sapiens	P62258	Pull Down	16407301
Intra	MAP3K3	Q99759	YWHAB	Homo sapiens	P31946	CoIP	18308725
Intra	MAP3K3	Q99759	YWHAB	Homo sapiens	P31946	TAP	14743216
Intra	MAP3K3	Q99759	YWHAG	Homo sapiens	P61981	TAP	14743216
Intra	MAP3K3	Q99759	YWHAG	Homo sapiens	P61981	Pull Down	32707033
Intra	MAP3K3	Q99759	YWHAQ	Homo sapiens	P27348	TAP	14743216

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Verrucous Hemangioma

Verrucous Keratotic Hemangioma

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Ciliary Dyskinesia, Primary, 20

Primary Ciliary Dyskinesia 20	CILD20
Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus
Ics20	Immotile Cilia Syndrome 20
Dyskinesia, Ciliary, Primary, 20

Non-Syndromic X-Linked Intellectual Disability 107

Mrx107

X-Linked Mental Retardation 107

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Senile Angioma

Senile Hemangioma

Senile Naevus Of Skin

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome	KTS
Ktw Syndrome	Angioosteohypertrophy Syndrome
Angio-Osteohypertrophy Syndrome	Klippel Trenaunay Syndrome
Klippel-Trénaunay-Weber Syndrome	Haemangiectatic Hypertrophy
Weber-Klippel-Trenaunay	Congenital Dysplastic Angiopathy
Klippel-Trenaunay Disease	Weber Klippel Trenaunay

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08056	MAP3K3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAP3K3	VGNC	VGNC:42973
Bos taurus	MAP3K3	VGNC	VGNC:31196
Rattus norvegicus	MAP3K3	RGD	RGD:1304575
Macaca mulatta	MAP3K3	VGNC	VGNC:81462
Mus musculus	MAP3K3	MGD	MGI:1346874
Felis catus	MAP3K3	VGNC	VGNC:97495

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