2. Gene
  3. RNF20 - ring finger protein 20 Gene

RNF20 - ring finger protein 20 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BRE1; BRE1A; hBRE1

Gene ID: 56254 | Gene type: protein coding

About RNF20

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:101,533,853-101,563,344 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.7), brain (RPKM 13.7) and 25 other tissues.

Summary

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin Ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

RNF20 Products(1)

mRNA Protein Name
NM_019592.7 NP_062538.5 E3 ubiquitin-protein ligase BRE1A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone H2B C-terminal K residue ubiquitin ligase activity IMP
IMP: Inferred from mutant phenotype
16337599 GOA
enables histone binding IDA
IDA: Inferred from direct assay
16337599 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
19575011 GOA
enables p53 binding IDA
IDA: Inferred from direct assay
16337599 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16307923 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16337599 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16307923 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16307923 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19037095 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
18832071 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16713563 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16307923 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
19037095 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18832071 GOA
NOT involved in regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19575011 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19037095 GOA
Cellular Component GO Annotation Evidence Reference Source
part of HULC complex IDA
IDA: Inferred from direct assay
19410543 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
19037095 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16307923 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16307923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF20 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (922 - 960)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase BRE1A

BRE1 E3 ubiquitin ligase homolog

RNF20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Array
25416956
Intra RNF20 Q5VTR2 CHEK2 Homo sapiens O96017
Anti Tag CoIP
25640309
Intra RNF20 Q5VTR2 RNF40 Homo sapiens O75150
Anti Tag CoIP
19410543
Intra RNF20 Q5VTR2 RNF40 Homo sapiens O75150
Chromatography
19410543
Intra RNF20 Q5VTR2 RNF40 Homo sapiens O75150
GMS
16307923
Intra RNF20 Q5VTR2 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
32296183
Intra RNF20 Q5VTR2 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
32296183
Intra RNF20 Q5VTR2 TACC3 Homo sapiens Q9Y6A5
Y2H Array
32296183
Intra RNF20 Q5VTR2 UBE2E1 Homo sapiens P51965
Pull Down
16307923
Intra RNF20 Q5VTR2 HTT Homo sapiens P42858
Y2H Prey Pooling
23275563
Intra RNF20 Q5VTR2 HTT Homo sapiens P42858
Y2H
17500595
Intra RNF20 Q5VTR2 COPS5 Homo sapiens Q92905
Biochemical
19214193
Intra RNF20 Q5VTR2 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra RNF20 Q5VTR2 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra RNF20 Q5VTR2 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra RNF20 Q5VTR2 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra RNF20 Q5VTR2 CDC73 Homo sapiens Q6P1J9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12075 RNF20 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RNF20 VGNC VGNC:76704
Felis catus RNF20 VGNC VGNC:64689
Canis familiaris RNF20 VGNC VGNC:45653
Mus musculus RNF20 MGD MGI:1925927
Rattus norvegicus RNF20 RGD RGD:1311936
Bos taurus RNF20 VGNC VGNC:34047
Others RNF20 NCBI