CCL28 - C-C motif chemokine ligand 28 Gene

Homo sapiens

Also known as MEC; CCK1; SCYA28

Gene ID: 56477 | Gene type: protein coding

About CCL28

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,356,975-43,412,391 (from NCBI)

This gene has 4 transcripts (splice variants), 99 orthologues and 1 paralogue. Biased expression in salivary gland (RPKM 40.6), colon (RPKM 10.6) and 5 other tissues.

Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

CCL28 Products(4)

mRNA	Protein	Name
NM_001301873.2	NP_001288802.1	C-C motif chemokine 28 isoform a precursor
NM_001301874.2	NP_001288803.1	C-C motif chemokine 28 isoform a precursor
NM_001301875.2	NP_001288804.1	C-C motif chemokine 28 isoform b
NM_148672.3	NP_683513.1	C-C motif chemokine 28 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	18308860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	12538707	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	18308860	GOA
involved in cytolysis in another organism	IMP IMP: Inferred from mutant phenotype	12538707	GOA
involved in killing of cells of another organism	IMP IMP: Inferred from mutant phenotype	12538707	GOA
involved in negative regulation of leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	18308860	GOA
involved in positive regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	18308860	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12538707	GOA
colocalizes with secretory granule	IDA IDA: Inferred from direct assay	12538707	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL28 Protein Structure

IL8

0
100
127 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 28

CC chemokine CCL28

Recombinant CCL28 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7250	MEC/CCL28 Protein, Human	Q9NRJ3-1 (S20-Y127)	≥95%
HY-P75447	MEC/CCL28 Protein, Human (His)	Q9NRJ3-1 (I23-Y127)	≥95%

Related Diseases

Diseases

Alias

Pancreatitis

Mumps Pancreatitis

Acute Hemorrhagic Pancreatitis

Pancreatitis, Acute Hemorrhagic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02098	CCL28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCL28	RGD	RGD:619937
Canis familiaris	CCL28	VGNC	VGNC:38890
Mus musculus	CCL28	MGD	MGI:1861731
Bos taurus	CCL28	VGNC	VGNC:26953
Macaca mulatta	CCL28	VGNC	VGNC:70815
Others	CCL28	NCBI

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