EIF4ENIF1 - eukaryotic translation initiation factor 4E nuclear import factor 1 Gene

Homo sapiens

Also known as 4E-T; Clast4

Gene ID: 56478 | Gene type: protein coding

About EIF4ENIF1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,436,963-31,493,568 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 19.7), brain (RPKM 7.2) and 25 other tissues.

Summary

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

EIF4ENIF1 Products(3)

mRNA	Protein	Name
NM_001164501.2	NP_001157973.1	eukaryotic translation initiation factor 4E transporter isoform a
NM_001164502.2	NP_001157974.1	eukaryotic translation initiation factor 4E transporter isoform b
NM_019843.4	NP_062817.2	eukaryotic translation initiation factor 4E transporter isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	22966201	GOA
enables nuclear export signal receptor activity	IDA IDA: Inferred from direct assay	10856257	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10856257	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in P-body assembly	IDA IDA: Inferred from direct assay	22966201	GOA
involved in P-body assembly	IMP IMP: Inferred from mutant phenotype	16157702	GOA
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	24335285	GOA
acts upstream of positive effect miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	24335285	GOA
involved in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA IDA: Inferred from direct assay	32354837	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	24335285	GOA
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	16157702	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	32354837	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	28216671	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	16157702	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28216671	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28216671	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4ENIF1 Protein Structure

EIF4E-T

0
200
400
600
800
985 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E transporter

2610509L04Rik

EIF4ENIF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF4ENIF1	Q9NRA8	EIF4E2	Homo sapiens	O60573-1	Anti Tag CoIP	28698298
Intra	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730-1	Anti Tag CoIP	28698298
Intra	EIF4ENIF1	Q9NRA8	DDX6	Homo sapiens	P26196	BN-PAGE	26184334
Intra	EIF4ENIF1	Q9NRA8	HNRNPF	Homo sapiens	P52597	Validated Y2H	25416956
Intra	EIF4ENIF1	Q9NRA8	HNRNPF	Homo sapiens	P52597	Y2H Array	25416956
Intra	EIF4ENIF1	Q9NRA8	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	EIF4ENIF1	Q9NRA8	TXLNA	Homo sapiens	P40222	Y2H Array	25416956
Intra	EIF4ENIF1	Q9NRA8	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	25416956
Intra	EIF4ENIF1	Q9NRA8	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	EIF4ENIF1	Q9NRA8	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	EIF4ENIF1	Q9NRA8	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	EIF4ENIF1	Q9NRA8	OIP5	Homo sapiens	O43482	Validated Y2H	25416956
Intra	EIF4ENIF1	Q9NRA8	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	25416956
Intra	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Y2H Array	25416956
Intra	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Pull Down	10856257
Intra	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Y2H Pooling	19060904
Intra	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Validated Y2H	25416956
Intra	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Y2H Array	19060904
Intra	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Affinity Chrom	10856257
Intra	EIF4ENIF1	Q9NRA8	DTX2	Homo sapiens	Q86UW9	Validated Y2H	25416956
Intra	EIF4ENIF1	Q9NRA8	DTX2	Homo sapiens	Q86UW9	Y2H Array	25416956
Intra	EIF4ENIF1	Q9NRA8	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	25416956
Intra	EIF4ENIF1	Q9NRA8	KRT19	Homo sapiens	P08727	Validated Y2H	25416956
Intra	EIF4ENIF1	Q9NRA8	EFHC1	Homo sapiens	Q5JVL4	Y2H Array	25416956
Intra	EIF4ENIF1	Q9NRA8	EFHC1	Homo sapiens	Q5JVL4	Y2H Prey Pooling	25416956
Intra	EIF4ENIF1	Q9NRA8	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	EIF4ENIF1	Q9NRA8	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	25416956
Intra	EIF4ENIF1	Q9NRA8	TTC19	Homo sapiens	Q6DKK2	Y2H Array	25416956
Intra	EIF4ENIF1	Q9NRA8	TTC19	Homo sapiens	Q6DKK2	Y2H Prey Pooling	25416956
Cross	EIF4ENIF1	Q9NRA8	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Y2H	18985028
Cross	EIF4ENIF1	Q9NRA8	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Y2H Prey Pooling	18985028
Cross	EIF4ENIF1	Q9NRA8	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Pull Down	18985028

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Suppurative Lymphadenitis

Suppurative Lymphadenopathy

Thymus Lymphoma

Thymic Lymphoma

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04280	EIF4ENIF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EIF4ENIF1	VGNC	VGNC:72054
Mus musculus	EIF4ENIF1	MGD	MGI:1921453
Rattus norvegicus	EIF4ENIF1	RGD	RGD:1560908
Bos taurus	EIF4ENIF1	VGNC	VGNC:28414
Felis catus	EIF4ENIF1	VGNC	VGNC:61794
Canis familiaris	EIF4ENIF1	VGNC	VGNC:40288

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