2. Gene
  3. EIF4ENIF1 - eukaryotic translation initiation factor 4E nuclear import factor 1 Gene

EIF4ENIF1 - eukaryotic translation initiation factor 4E nuclear import factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 4E-T; Clast4

Gene ID: 56478 | Gene type: protein coding

About EIF4ENIF1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,436,963-31,493,568 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 19.7), brain (RPKM 7.2) and 25 other tissues.

Summary

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

EIF4ENIF1 Products(3)

mRNA Protein Name
NM_001164501.2 NP_001157973.1 eukaryotic translation initiation factor 4E transporter isoform a
NM_001164502.2 NP_001157974.1 eukaryotic translation initiation factor 4E transporter isoform b
NM_019843.4 NP_062817.2 eukaryotic translation initiation factor 4E transporter isoform a

EIF4ENIF1 Protein Structure

EIF4E-T

EIF4E-T: Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E (30 - 713)

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  • 985 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E transporter

2610509L04Rik

Related Diseases

Diseases Alias
Suppurative Lymphadenitis

Suppurative Lymphadenopathy
Thymus Lymphoma

Thymic Lymphoma
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04280 EIF4ENIF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EIF4ENIF1 VGNC VGNC:72054
Mus musculus EIF4ENIF1 MGD MGI:1921453
Rattus norvegicus EIF4ENIF1 RGD RGD:1560908
Bos taurus EIF4ENIF1 VGNC VGNC:28414
Felis catus EIF4ENIF1 VGNC VGNC:61794
Canis familiaris EIF4ENIF1 VGNC VGNC:40288