DDX6 - DEAD-box helicase 6 Gene

Homo sapiens

Also known as P54; RCK; HLR2; IDDILF; Rck/p54

Gene ID: 1656 | Gene type: protein coding

About DDX6

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,747,763-118,791,744 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues, 38 paralogues and is associated with 58 phenotypes. Ubiquitous expression in brain (RPKM 27.6), lymph node (RPKM 26.5) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

DDX6 Products(2)

mRNA	Protein	Name
NM_001257191.3	NP_001244120.1	probable ATP-dependent RNA helicase DDX6
NM_004397.6	NP_004388.2	probable ATP-dependent RNA helicase DDX6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16364915	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	24768540	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within P-body assembly	IDA IDA: Inferred from direct assay	20826699	GOA
involved in P-body assembly	IDA IDA: Inferred from direct assay	27342281	GOA
involved in P-body assembly	IMP IMP: Inferred from mutant phenotype	25995375	GOA
acts upstream of positive effect miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	27342281	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	27342281	GOA
involved in viral RNA genome packaging	IMP IMP: Inferred from mutant phenotype	22022269	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	16699599	GOA
located in P-body	IMP IMP: Inferred from mutant phenotype	22022269	GOA
part of RISC complex	IDA IDA: Inferred from direct assay	20616046	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	26184334	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	17392519	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26184334	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX6 Protein Structure

DEAD

Helicase_C

0
100
200
300
400
483 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX6

ATP-dependent RNA helicase p54

DDX6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDX6	P26196	PNMA5	Homo sapiens	Q96PV4	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	DDX6	P26196	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	DDX6	P26196	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	DDX6	P26196	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	DDX6	P26196	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	DDX6	P26196	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	ZBTB14	Homo sapiens	O43829	Y2H Array	32296183
Intra	DDX6	P26196	NONO	Homo sapiens	Q15233-2	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	NONO	Homo sapiens	Q15233-2	Y2H Array	25416956
Intra	DDX6	P26196	CNKSR3	Homo sapiens	Q6P9H4	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	CNKSR3	Homo sapiens	Q6P9H4	Validated Y2H	32296183
Intra	DDX6	P26196	CNKSR3	Homo sapiens	Q6P9H4	Y2H Array	32296183
Intra	DDX6	P26196	SLAIN1	Homo sapiens	Q8ND83	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	SLAIN1	Homo sapiens	Q8ND83	Validated Y2H	32296183
Intra	DDX6	P26196	SLAIN1	Homo sapiens	Q8ND83	Y2H Array	32296183
Intra	DDX6	P26196	INKA1	Homo sapiens	Q96EL1	Y2H Array	32296183
Intra	DDX6	P26196	INKA1	Homo sapiens	Q96EL1	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	INKA1	Homo sapiens	Q96EL1	Validated Y2H	32296183
Intra	DDX6	P26196	SIPA1L2	Homo sapiens	Q9P2F8-2	BFG-2H	27107012
Intra	DDX6	P26196	SIPA1L2	Homo sapiens	Q9P2F8-2	Y2H Array	32296183
Intra	DDX6	P26196	SIPA1L2	Homo sapiens	Q9P2F8-2	Validated Y2H	32296183
Intra	DDX6	P26196	SIPA1L2	Homo sapiens	Q9P2F8-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	SIPA1L2	Homo sapiens	Q9P2F8-2	Validated Y2H	27107012
Intra	DDX6	P26196	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	DDX6	P26196	DES	Homo sapiens	P17661	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	DES	Homo sapiens	P17661	Y2H Array	32296183
Intra	DDX6	P26196	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	DDX6	P26196	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	DDX6	P26196	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	DDX6	P26196	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	DDX6	P26196	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	DDX6	P26196	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	FXR1	Homo sapiens	P51114-2	Validated Y2H	32296183
Intra	DDX6	P26196	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	DDX6	P26196	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	DDX6	P26196	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	DDX6	P26196	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	DDX6	P26196	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	30886144
Intra	DDX6	P26196	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	DDX6	P26196	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	DDX6	P26196	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	DDX6	P26196	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	DDX6	P26196	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	DDX6	P26196	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	DDX6	P26196	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	DDX6	P26196	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	DDX6	P26196	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Array	32296183
Intra	DDX6	P26196	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	DDX6	P26196	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	DDX6	P26196	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Array	32296183
Intra	DDX6	P26196	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	ZBTB10	Homo sapiens	Q96DT7-3	Validated Y2H	32296183
Intra	DDX6	P26196	SCYL1	Homo sapiens	Q96KG9-4	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	SCYL1	Homo sapiens	Q96KG9-4	Validated Y2H	32296183
Intra	DDX6	P26196	SCYL1	Homo sapiens	Q96KG9-4	Y2H Array	32296183
Intra	DDX6	P26196	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	DDX6	P26196	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	DDX6	P26196	CCDC14	Homo sapiens	Q49A88-3	Validated Y2H	32296183
Intra	DDX6	P26196	CCDC14	Homo sapiens	Q49A88-3	Y2H Array	32296183
Intra	DDX6	P26196	CCDC14	Homo sapiens	Q49A88-3	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	DDX6	P26196	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	DDX6	P26196	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	DDX6	P26196	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	ZC2HC1C	Homo sapiens	Q53FD0-2	Validated Y2H	32296183
Intra	DDX6	P26196	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	DDX6	P26196	SPATA6	Homo sapiens	Q9NWH7-2	Validated Y2H	32296183
Intra	DDX6	P26196	SPATA6	Homo sapiens	Q9NWH7-2	Y2H Array	32296183
Intra	DDX6	P26196	SPATA6	Homo sapiens	Q9NWH7-2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	DDX6	P26196	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	DDX6	P26196	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	DDX6	P26196	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Cross	DDX6	P26196	N	SARS-CoV-2	P0DTC9	Confocal	35107372
Cross	DDX6	P26196	N	SARS-CoV-2	P0DTC9	Anti Bait CoIP	35107372
Intra	DDX6	P26196	PATL1	Homo sapiens	Q86TB9	Anti Bait CoIP	20584987
Intra	DDX6	P26196	PATL1	Homo sapiens	Q86TB9	BN-PAGE	26184334
Intra	DDX6	P26196	PATL1	Homo sapiens	Q86TB9	Confocal	20584987
Intra	DDX6	P26196	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	26184334
Intra	DDX6	P26196	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	35271311
Intra	DDX6	P26196	JAKMIP1	Homo sapiens	Q96N16	Validated Y2H	32296183
Intra	DDX6	P26196	JAKMIP1	Homo sapiens	Q96N16	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	JAKMIP1	Homo sapiens	Q96N16	Y2H Array	32296183
Intra	DDX6	P26196	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	DDX6	P26196	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	DDX6	P26196	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	DDX6	P26196	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	DDX6	P26196	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Validated Y2H	32296183
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Array	25416956
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Array	32296183
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Anti Tag CoIP	26184334
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Anti Tag CoIP	35271311
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	EIF4ENIF1	Homo sapiens	Q9NRA8	Validated Y2H	25416956
Intra	DDX6	P26196	PDLIM7	Homo sapiens	Q9NR12	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	PDLIM7	Homo sapiens	Q9NR12	Validated Y2H	32296183
Intra	DDX6	P26196	PDLIM7	Homo sapiens	Q9NR12	Y2H Array	32296183
Intra	DDX6	P26196	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	DDX6	P26196	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	DDX6	P26196	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	DCP1A	Homo sapiens	Q9NPI6	IF	16364915
Intra	DDX6	P26196	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	33961781
Intra	DDX6	P26196	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	28514442
Intra	DDX6	P26196	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	35271311
Intra	DDX6	P26196	DCP1A	Homo sapiens	Q9NPI6	TAP	24981860
Intra	DDX6	P26196	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	16364915
Intra	DDX6	P26196	BIRC7	Homo sapiens	Q96CA5	Validated Y2H	25416956
Intra	DDX6	P26196	BIRC7	Homo sapiens	Q96CA5	Validated Y2H	32296183
Intra	DDX6	P26196	BIRC7	Homo sapiens	Q96CA5	Y2H Array	32296183
Intra	DDX6	P26196	BIRC7	Homo sapiens	Q96CA5	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	BIRC7	Homo sapiens	Q96CA5	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	BIRC7	Homo sapiens	Q96CA5	Y2H Array	31515488
Intra	DDX6	P26196	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	DDX6	P26196	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	DDX6	P26196	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	28683311
Intra	DDX6	P26196	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	28683311
Intra	DDX6	P26196	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	MESD	Homo sapiens	Q14696	Validated Y2H	32296183
Intra	DDX6	P26196	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	DDX6	P26196	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	DDX6	P26196	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	DDX6	P26196	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	DDX6	P26196	ATXN2	Homo sapiens	Q99700	Anti Tag CoIP	35271311
Intra	DDX6	P26196	ATXN2	Homo sapiens	Q99700	TAP	24981860
Intra	DDX6	P26196	ATXN2	Homo sapiens	Q99700	Y2H	17392519
Intra	DDX6	P26196	ATXN2	Homo sapiens	Q99700	Anti Tag CoIP	26184334
Intra	DDX6	P26196	ATXN2	Homo sapiens	Q99700	Anti Tag CoIP	33961781
Intra	DDX6	P26196	ATXN2	Homo sapiens	Q99700	Confocal	17392519
Intra	DDX6	P26196	ATXN2	Homo sapiens	Q99700	Anti Bait CoIP	17392519
Intra	DDX6	P26196	JUP	Homo sapiens	P14923	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	JUP	Homo sapiens	P14923	Y2H Array	32296183
Intra	DDX6	P26196	IK	Homo sapiens	Q13123	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	IK	Homo sapiens	Q13123	Validated Y2H	32296183
Intra	DDX6	P26196	IK	Homo sapiens	Q13123	Y2H Array	32296183
Intra	DDX6	P26196	SHMT1	Homo sapiens	P34896	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	SHMT1	Homo sapiens	P34896	Validated Y2H	32296183
Intra	DDX6	P26196	SHMT1	Homo sapiens	P34896	Y2H Array	32296183
Intra	DDX6	P26196	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	DDX6	P26196	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	DDX6	P26196	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	DDX6	P26196	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	DDX6	P26196	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	DDX6	P26196	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	DDX6	P26196	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	DDX6	P26196	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	DDX6	P26196	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	DDX6	P26196	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	32296183
Intra	DDX6	P26196	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	DDX6	P26196	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	DDX6	P26196	ZBTB43	Homo sapiens	O43298	Y2H Array	32296183
Intra	DDX6	P26196	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	DDX6	P26196	RBM11	Homo sapiens	P57052	Validated Y2H	32296183
Intra	DDX6	P26196	RBM11	Homo sapiens	P57052	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	RBM11	Homo sapiens	P57052	Y2H Array	32296183
Intra	DDX6	P26196	TRIM37	Homo sapiens	O94972	Validated Y2H	25416956
Intra	DDX6	P26196	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	PAK5	Homo sapiens	Q9P286	Validated Y2H	32296183
Intra	DDX6	P26196	PAK5	Homo sapiens	Q9P286	Y2H Array	32296183
Intra	DDX6	P26196	BEGAIN	Homo sapiens	Q9BUH8	Y2H Array	32296183
Intra	DDX6	P26196	BEGAIN	Homo sapiens	Q9BUH8	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	BEGAIN	Homo sapiens	Q9BUH8	Validated Y2H	32296183
Intra	DDX6	P26196	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	DDX6	P26196	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	DDX6	P26196	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	DDX6	P26196	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	DDX6	P26196	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	DDX6	P26196	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	DDX6	P26196	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	DDX17	Homo sapiens	Q92841	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	DDX17	Homo sapiens	Q92841	Validated Y2H	32296183
Intra	DDX6	P26196	DDX17	Homo sapiens	Q92841	Y2H Array	32296183
Intra	DDX6	P26196	DDX17	Homo sapiens	Q92841	Anti Tag CoIP	26184334
Intra	DDX6	P26196	RUNDC3A	Homo sapiens	Q59EK9	Y2H Array	25416956
Intra	DDX6	P26196	RUNDC3A	Homo sapiens	Q59EK9	Y2H Prey Pooling	25416956
Intra	DDX6	P26196	PRPH	Homo sapiens	P41219	Validated Y2H	32296183
Intra	DDX6	P26196	PRPH	Homo sapiens	P41219	Y2H Array	32296183
Intra	DDX6	P26196	PRPH	Homo sapiens	P41219	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	DDX6	P26196	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	DDX6	P26196	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	USH1G	Homo sapiens	Q495M9	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	USH1G	Homo sapiens	Q495M9	Validated Y2H	32296183
Intra	DDX6	P26196	USH1G	Homo sapiens	Q495M9	Y2H Array	32296183
Intra	DDX6	P26196	NAB2	Homo sapiens	Q15742	Y2H Array	32296183
Intra	DDX6	P26196	NAB2	Homo sapiens	Q15742	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	NAB2	Homo sapiens	Q15742	Validated Y2H	32296183
Intra	DDX6	P26196	DNAAF11	Homo sapiens	Q86X45	Validated Y2H	32296183
Intra	DDX6	P26196	DNAAF11	Homo sapiens	Q86X45	Y2H Array	32296183
Intra	DDX6	P26196	DNAAF11	Homo sapiens	Q86X45	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Validated Y2H	32296183
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	33961781
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Y2H Array	32296183
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	28514442
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	TAP	24981860
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Y2H Array	29892012
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	BN-PAGE	26184334
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	35271311
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Y2H Array	31515488
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Validated Y2H	25416956
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Y2H Prey Pooling	32296183
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	26184334
Intra	DDX6	P26196	EDC3	Homo sapiens	Q96F86	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

DDX6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82507	DDX6 Antibody (YA2252)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies

IDDILF

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Telecanthus

Childhood Liposarcoma

Pediatric Liposarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03663	DDX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DDX6	MGD	MGI:104976
Bos taurus	DDX6	VGNC	VGNC:27981
Canis familiaris	DDX6	VGNC	VGNC:39869
Felis catus	DDX6	VGNC	VGNC:61420
Macaca mulatta	DDX6	VGNC	VGNC:71764
Rattus norvegicus	DDX6	RGD	RGD:1564560

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