2. Gene
  3. PSMB2 - proteasome 20S subunit beta 2 Gene

PSMB2 - proteasome 20S subunit beta 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HC7-I

Gene ID: 5690 | Gene type: protein coding

About PSMB2

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,599,541-35,641,526 (from NCBI)

This gene has 3 transcripts (splice variants), 220 orthologues and 18 paralogues. Ubiquitous expression in placenta (RPKM 11.8), lymph node (RPKM 10.8) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PSMB2 Products(3)

mRNA Protein Name
NM_001199779.2 NP_001186708.1 proteasome subunit beta type-2 isoform 2
NM_001199780.2 NP_001186709.1 proteasome subunit beta type-2 isoform 3
NM_002794.5 NP_002785.1 proteasome subunit beta type-2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14733938 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
34711951 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
34711951 GOA
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
part of proteasome core complex IDA
IDA: Inferred from direct assay
34711951 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB2 Protein Structure

Proteasome

Proteasome: Proteasome subunit (5 - 183)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

proteasome subunit beta type-2

macropain subunit C7-I

PSMB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PSMB2 P49721 KRT13 Homo sapiens A1A4E9
Y2H Array
25416956
Intra
PSMB2 P49721 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra
PSMB2 P49721 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra
PSMB2 P49721 KRTAP19-7 Homo sapiens Q3SYF9
Validated Y2H
32296183
Intra
PSMB2 P49721 KRTAP19-5 Homo sapiens Q3LI72
Validated Y2H
32296183
Intra
PSMB2 P49721 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
PSMB2 P49721 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
PSMB2 P49721 KRTAP19-6 Homo sapiens Q3LI70
Validated Y2H
32296183
Intra
PSMB2 P49721 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
Intra
PSMB2 P49721 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
Intra
PSMB2 P49721 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
Intra
PSMB2 P49721 KRTAP19-1 Homo sapiens Q8IUB9
Validated Y2H
32296183
Intra
PSMB2 P49721 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
Intra
PSMB2 P49721 PSMB5 Homo sapiens P28074
Anti Tag CoIP
33961781
Intra
PSMB2 P49721 PSMB5 Homo sapiens P28074
Y2H
14733938
Intra
PSMB2 P49721 PSMB5 Homo sapiens P28074
Anti Tag CoIP
28514442
Intra
PSMB2 P49721 PSMB5 Homo sapiens P28074
Pull Down
35858375
Intra
PSMB2 P49721 PSMA1 Homo sapiens P25786
Pull Down
35858375
Intra
PSMB2 P49721 PSMA1 Homo sapiens P25786
Anti Tag CoIP
33961781
Intra
PSMB2 P49721 PSMA1 Homo sapiens P25786
Y2H
14733938
Intra
PSMB2 P49721 PSMB1 Homo sapiens P20618
Anti Tag CoIP
33961781
Intra
PSMB2 P49721 PSMB1 Homo sapiens P20618
Anti Tag CoIP
28514442
Intra
PSMB2 P49721 PSMB1 Homo sapiens P20618
Anti Tag CoIP
35271311
Intra
PSMB2 P49721 PSMB1 Homo sapiens P20618
Y2H
17948026
Intra
PSMB2 P49721 PSMB1 Homo sapiens P20618
Pull Down
35858375
Intra
PSMB2 P49721 KCTD9 Homo sapiens Q7L273
Y2H Array
25416956
Intra
PSMB2 P49721 KCTD9 Homo sapiens Q7L273
Validated Y2H
25416956
Intra
PSMB2 P49721 AXIN2 Homo sapiens Q9Y2T1
Y2H Prey Pooling
32296183
Intra
PSMB2 P49721 AXIN2 Homo sapiens Q9Y2T1
Y2H Array
32296183
Intra
PSMB2 P49721 AXIN2 Homo sapiens Q9Y2T1
Validated Y2H
32296183
Intra
PSMB2 P49721 PSMB3 Homo sapiens P49720
Anti Tag CoIP
33961781
Intra
PSMB2 P49721 PSMB3 Homo sapiens P49720
Y2H
14733938
Intra
PSMB2 P49721 PSMB3 Homo sapiens P49720
Anti Tag CoIP
28514442
Intra
PSMB2 P49721 PSMB3 Homo sapiens P49720
Pull Down
35858375
Intra
PSMB2 P49721 PSMB3 Homo sapiens P49720
Y2H
17948026
Intra
PSMB2 P49721 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
PSMB2 P49721 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
PSMB2 P49721 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
PSMB2 P49721 POMP Homo sapiens Q9Y244
Anti Tag CoIP
35271311
Intra
PSMB2 P49721 POMP Homo sapiens Q9Y244
Anti Tag CoIP
33961781
Intra
PSMB2 P49721 POMP Homo sapiens Q9Y244
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11302 PSMB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PSMB2 VGNC VGNC:76443
Felis catus PSMB2 VGNC VGNC:69108
Mus musculus PSMB2 MGD MGI:1347045
Rattus norvegicus PSMB2 RGD RGD:61874
Bos taurus PSMB2 VGNC VGNC:33446
Canis familiaris PSMB2 VGNC VGNC:45095