FBXO28 - F-box protein 28 Gene

Homo sapiens (human)

Also known as Fbx28; DEE100; CENP-30

Gene ID: 23219 | Gene type: protein coding

About FBXO28

Summary

Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXO28 Products(1)

mRNA	Protein	Name
NR_049764.2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in kinetochore	IDA IDA: Inferred from direct assay	20813266	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

F-box only protein 28

centromere protein 30

FBXO28 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FBXO28	Q9NVF7	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	FBXO28	Q9NVF7	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	FBXO28	Q9NVF7	CAVIN1	Homo sapiens	Q6NZI2	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	CAVIN1	Homo sapiens	Q6NZI2	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	SKP1	Homo sapiens	P63208	Validated Y2H	25416956
Intra	FBXO28	Q9NVF7	SKP1	Homo sapiens	P63208	Y2H Array	25416956
Intra	FBXO28	Q9NVF7	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	FBXO28	Q9NVF7	EMILIN3	Homo sapiens	Q9NT22	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	EMILIN3	Homo sapiens	Q9NT22	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	SPAG5	Homo sapiens	Q96R06	Validated Y2H	25416956
Intra	FBXO28	Q9NVF7	SPAG5	Homo sapiens	Q96R06	Y2H Array	25416956
Intra	FBXO28	Q9NVF7	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	25416956
Intra	FBXO28	Q9NVF7	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	28514442
Intra	FBXO28	Q9NVF7	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	TRAF5	Homo sapiens	O00463	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	33961781
Intra	FBXO28	Q9NVF7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	GOLGA2	Homo sapiens	Q08379	Y2H	21516116
Intra	FBXO28	Q9NVF7	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	FBXO28	Q9NVF7	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	EXOC7	Homo sapiens	Q9UPT5-1	Validated Y2H	32296183
Intra	FBXO28	Q9NVF7	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	25416956
Intra	FBXO28	Q9NVF7	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	25416956
Intra	FBXO28	Q9NVF7	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	25416956
Intra	FBXO28	Q9NVF7	GCC1	Homo sapiens	Q96CN9	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	AGGF1	Homo sapiens	Q8N302	Y2H Array	32296183
Intra	FBXO28	Q9NVF7	AGGF1	Homo sapiens	Q8N302	Y2H Prey Pooling	32296183
Intra	FBXO28	Q9NVF7	HOMER3	Homo sapiens	Q9NSC5	Anti Tag CoIP	33961781
Intra	FBXO28	Q9NVF7	STX1B	Homo sapiens	P61266	BRET	38225382

Cross: Cross-species interaction Intra: Intraspecies interaction

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