NGB - neuroglobin Gene

Homo sapiens

Gene ID: 58157 | Gene type: protein coding

About NGB

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,265,483-77,271,206 (from NCBI)

This gene has 1 transcript (splice variant) and 180 orthologues. Biased expression in adrenal (RPKM 4.2), brain (RPKM 1.8) and 3 other tissues.

Summary

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among Other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

NGB Products(1)

mRNA	Protein	Name
NM_021257.4	NP_067080.1	neuroglobin

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP-dissociation inhibitor activity	IDA IDA: Inferred from direct assay	12860983	GOA
enables nitrite reductase activity	IDA IDA: Inferred from direct assay	21296891	GOA
enables oxygen binding	IDA IDA: Inferred from direct assay	11029004	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	18302932	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NGB Protein Structure

Globin

0
100
151 a.a.

Protein Preferred Names

Protein Names

neuroglobin

NGB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NGB	Q9NPG2	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	NGB	Q9NPG2	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	NGB	Q9NPG2	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	NGB	Q9NPG2	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	NGB	Q9NPG2	VAC14	Homo sapiens	Q08AM6	Y2H Array	25416956
Intra	NGB	Q9NPG2	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	NGB	Q9NPG2	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	L3MBTL3	Homo sapiens	Q96JM7	Y2H Prey Pooling	25416956
Intra	NGB	Q9NPG2	L3MBTL3	Homo sapiens	Q96JM7	Y2H Array	25416956
Intra	NGB	Q9NPG2	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	NGB	Q9NPG2	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	NGB	Q9NPG2	BTBD2	Homo sapiens	Q9BX70	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	BTBD2	Homo sapiens	Q9BX70	Y2H Array	32296183
Intra	NGB	Q9NPG2	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	NGB	Q9NPG2	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	NGB	Q9NPG2	TDO2	Homo sapiens	P48775	Validated Y2H	25416956
Intra	NGB	Q9NPG2	TDO2	Homo sapiens	P48775	Y2H Array	32296183
Intra	NGB	Q9NPG2	TDO2	Homo sapiens	P48775	Y2H Prey Pooling	25416956
Intra	NGB	Q9NPG2	TDO2	Homo sapiens	P48775	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956
Intra	NGB	Q9NPG2	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	NGB	Q9NPG2	GATAD2B	Homo sapiens	Q8WXI9	Y2H Array	32296183
Intra	NGB	Q9NPG2	GATAD2B	Homo sapiens	Q8WXI9	Y2H Prey Pooling	32296183
Intra	NGB	Q9NPG2	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	NGB	Q9NPG2	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	NGB	Q9NPG2	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ischemia

Acute Coronary Syndrome

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12697	NGB 2904	Antagonist	98.28%	Unkown
HY-12697A	NGB 2904 hydrochloride	Antagonist	/	Unkown
HY-RS09274	NGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NGB	MGD	MGI:2151886
Canis familiaris	NGB	VGNC	VGNC:43793
Macaca mulatta	NGB	VGNC	VGNC:84408
Bos taurus	NGB	VGNC	VGNC:32058
Rattus norvegicus	NGB	RGD	RGD:621461

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