NGB - neuroglobin Gene

Homo sapiens

Gene ID: 58157 | Gene type: protein coding

About NGB

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,265,483-77,271,206 (from NCBI)

This gene has 1 transcript (splice variant) and 180 orthologues. Biased expression in adrenal (RPKM 4.2), brain (RPKM 1.8) and 3 other tissues.

Summary

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

NGB Products(1)

mRNA	Protein	Name
NM_021257.4	NP_067080.1	neuroglobin

NGB Protein Structure

Globin

0
100
151 a.a.

Protein Preferred Names

Protein Names

neuroglobin

Related Diseases

Diseases

Alias

Ischemia

Acute Coronary Syndrome

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12697	NGB 2904	Antagonist	98.28%	Unkown
HY-12697A	NGB 2904 hydrochloride	Antagonist	/	Unkown
HY-RS09274	NGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NGB	MGD	MGI:2151886
Canis familiaris	NGB	VGNC	VGNC:43793
Macaca mulatta	NGB	VGNC	VGNC:84408
Bos taurus	NGB	VGNC	VGNC:32058
Rattus norvegicus	NGB	RGD	RGD:621461

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