TDO2 - tryptophan 2,3-dioxygenase Gene

Homo sapiens

Also known as TO; TDO; TPH2; TRPO; HYPTRP

Gene ID: 6999 | Gene type: protein coding

About TDO2

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,903,696-155,920,406 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 223 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 202.8) and appendix (RPKM 14.2).

Summary

This gene encodes a heme Enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in Cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

TDO2 Products(1)

mRNA	Protein	Name
NM_005651.4	NP_005642.1	tryptophan 2,3-dioxygenase

TDO2 Protein Structure

Trp_dioxygenase

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

tryptophan 2,3-dioxygenase

tryptamin 2,3-dioxygenase

Related Diseases

Diseases

Alias

Hypertryptophanemia

HYPTRP	Hypertryptophanemia, Familial
Familial Hypertryptophanemia

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Constipation

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Acute Porphyria

Porphyrias, Hepatic	Hepatic Porphyria
Porphyria Hepatic	Acute Intermittent Porphyria

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Variegate Porphyria

Porphyria Variegata	Protoporphyrinogen Oxidase Deficiency
VP	Ppox Deficiency
Porphyria, South African Type	Porphyria Variegata, Susceptibility To
Protocoproporphyria	Porphyria Variegate
Porphyria South African Type	Pv
Porphyria, Variegate	Vp - [Variegate Porphyria]

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114319	β-Cembrenediol		/	Unkown
HY-161348	AT-0174	Inhibitor	/	Unkown
HY-161996	IDO1-IN-25	Inhibitor	/	Unkown
HY-RS14331	TDO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TDO2	VGNC	VGNC:47217
Rattus norvegicus	TDO2	RGD	RGD:68370
Mus musculus	TDO2	MGD	MGI:1928486
Bos taurus	TDO2	VGNC	VGNC:35712
Macaca mulatta	TDO2	VGNC	VGNC:78298
Felis catus	TDO2	VGNC	VGNC:66044

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