2. Gene
  3. TDO2 - tryptophan 2,3-dioxygenase Gene

TDO2 - tryptophan 2,3-dioxygenase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TO; TDO; TPH2; TRPO; HYPTRP

Gene ID: 6999 | Gene type: protein coding

About TDO2

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,903,696-155,920,406 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 223 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 202.8) and appendix (RPKM 14.2).

Summary

This gene encodes a heme Enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in Cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

TDO2 Products(1)

mRNA Protein Name
NM_005651.4 NP_005642.1 tryptophan 2,3-dioxygenase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables heme binding IDA
IDA: Inferred from direct assay
27762317 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
24722188 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables tryptophan 2,3-dioxygenase activity IDA
IDA: Inferred from direct assay
27762317 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
27762317 GOA
involved in tryptophan catabolic process to kynurenine IDA
IDA: Inferred from direct assay
27762317 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDO2 Protein Structure

Trp_dioxygenase

Trp_dioxygenase: Tryptophan 2,3-dioxygenase (27 - 372)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

tryptophan 2,3-dioxygenase

tryptamin 2,3-dioxygenase

TDO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TDO2 P48775 NGB Homo sapiens Q9NPG2
Validated Y2H
32296183
Intra
TDO2 P48775 NGB Homo sapiens Q9NPG2
Y2H Array
25416956
Intra
TDO2 P48775 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
TDO2 P48775 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
TDO2 P48775 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
TDO2 P48775 PM20D2 Homo sapiens Q8IYS1
Validated Y2H
32296183
Intra
TDO2 P48775 AHCYL1 Homo sapiens O43865
Validated Y2H
32814053
Intra
TDO2 P48775 AHCYL1 Homo sapiens O43865
Y2H Pooling
32814053
Intra
TDO2 P48775 AHCYL1 Homo sapiens O43865
Y2H Array
32814053
Intra
TDO2 P48775 NR1D1 Homo sapiens P20393
Y2H Array
32296183
Intra
TDO2 P48775 NR1D1 Homo sapiens P20393
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Y2H Array
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 NMNAT1 Homo sapiens Q9HAN9
Y2H Array
24722188
Intra
TDO2 P48775 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 SDCBP Homo sapiens O00560
Y2H Array
24722188
Intra
TDO2 P48775 CDH1 Homo sapiens P12830
Y2H Array
32814053
Intra
TDO2 P48775 CDH1 Homo sapiens P12830
Y2H Pooling
32814053
Intra
TDO2 P48775 CDH1 Homo sapiens P12830
Validated Y2H
32814053
Intra
TDO2 P48775 EIF4E Homo sapiens P06730
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 EIF4E Homo sapiens P06730
Validated Y2H
25416956
Intra
TDO2 P48775 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Validated Y2H
25416956
Intra
TDO2 P48775 SDCBP2 Homo sapiens Q9H190
Y2H Array
25416956
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Anti Tag CoIP
33961781
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Validated Y2H
25416956
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Anti Tag CoIP
28514442
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Array
25416956
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Array
32296183
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Array
24722188
Intra
TDO2 P48775 ASMTL Homo sapiens O95671
Y2H Pooling
16189514
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Array
32296183
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Prey Pooling
32296183
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Array
24722188
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Validated Y2H
32296183
Intra
TDO2 P48775 TDO2 Homo sapiens P48775
Y2H Array
25416956
Intra
TDO2 P48775 MOB1A Homo sapiens Q9H8S9
Validated Y2H
32296183
Intra
TDO2 P48775 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
TDO2 P48775 ZFYVE26 Homo sapiens Q68DK2-5
Y2H Prey Pooling
25416956
Intra
TDO2 P48775 ZFYVE26 Homo sapiens Q68DK2-5
Validated Y2H
25416956
Intra
TDO2 P48775 ZFYVE26 Homo sapiens Q68DK2-5
Validated Y2H
32296183
Intra
TDO2 P48775 MOB3C Homo sapiens Q70IA8
Validated Y2H
25416956
Intra
TDO2 P48775 MOB3C Homo sapiens Q70IA8
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertryptophanemia

HYPTRP

Hypertryptophanemia, Familial

Familial Hypertryptophanemia
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Constipation
Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Acute Porphyria

Porphyrias, Hepatic

Hepatic Porphyria

Porphyria Hepatic

Acute Intermittent Porphyria
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Variegate Porphyria

Porphyria Variegata

Protoporphyrinogen Oxidase Deficiency

VP

Ppox Deficiency

Porphyria, South African Type

Porphyria Variegata, Susceptibility To

Protocoproporphyria

Porphyria Variegate

Porphyria South African Type

Pv

Porphyria, Variegate

Vp - [Variegate Porphyria]
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114319 β-Cembrenediol / Unkown
HY-161348 AT-0174 Inhibitor / Unkown
HY-161996 IDO1-IN-25 Inhibitor / Unkown
HY-RS14331 TDO2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TDO2 VGNC VGNC:47217
Rattus norvegicus TDO2 RGD RGD:68370
Mus musculus TDO2 MGD MGI:1928486
Bos taurus TDO2 VGNC VGNC:35712
Macaca mulatta TDO2 VGNC VGNC:78298
Felis catus TDO2 VGNC VGNC:66044