RAC3 - Rac family small GTPase 3 Gene

Homo sapiens

Gene ID: 5881 | Gene type: protein coding

About RAC3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,031,678-82,034,204 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 10.2), brain (RPKM 6.3) and 22 other tissues.

Summary

The protein encoded by this gene is a GTPase which belongs to the Ras superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

RAC3 Products(2)

mRNA	Protein	Name
NM_001316307.2	NP_001303236.1	ras-related C3 botulinum toxin substrate 3 isoform 2
NM_005052.3	NP_005043.1	ras-related C3 botulinum toxin substrate 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	11956649	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	11756406	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11956649	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	29276006	GOA
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11956649	GOA
involved in cell projection assembly	IDA IDA: Inferred from direct assay	11956649	GOA
involved in positive regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	11756406	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11756406	GOA
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21297961	GOA
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21297961	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell periphery	IDA IDA: Inferred from direct assay	11756406	GOA
located in endomembrane system	IDA IDA: Inferred from direct assay	11956649	GOA
part of filamentous actin	IDA IDA: Inferred from direct assay	16525025	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21297961	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21297961	GOA
located in growth cone	IDA IDA: Inferred from direct assay	16525025	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	16525025	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	16525025	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11756406	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAC3 Protein Structure

Ras

0
100
192 a.a.

Protein Preferred Names

Protein Names

ras-related C3 botulinum toxin substrate 3

p21-Rac3

RAC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAC3	P60763	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	RAC3	P60763	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	RAC3	P60763	NRBP1	Homo sapiens	Q9UHY1	Anti Tag CoIP	11956649
Intra	RAC3	P60763	ESR1	Homo sapiens	P03372	Phage Display	21217774
Intra	RAC3	P60763	ESR1	Homo sapiens	P03372	Y2H	21217774
Intra	RAC3	P60763	ESR1	Homo sapiens	P03372	Pull Down	21217774

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Structural Brain Anomalies And Dysmorphic Facies

NEDBAF

Ascaridiasis

Ascariasis

Toxic Megacolon

Megacolon, Toxic	Toxic Dilatation Of Colon
Toxic Functional Megacolon

Deafness, Autosomal Recessive 104

DFNB104	Autosomal Recessive Nonsyndromic Deafness 104
Autosomal Recessive Deafness 104	Deafness, Autosomal Recessive, 104
Deafness, Autosomal Recessive, Type 104

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia

Konigsmark Syndrome	DFNA1
Autosomal Dominant Nonsyndromic Deafness 1	Lfhl1
Deafness, Autosomal Dominant 1	Autosomal Dominant Deafness 1
Autosomal Dominant Deafness 1, With Or Without Thrombocytopenia	Hereditary Low Frequency Hearing Loss 1
Diaph1-Related Sensorineural Hearing Loss-Thrombocytopenia Syndrome	Diaph1-Related Sensorineural Deafness-Thrombocytopenia Syndrome
Hereditary Low-Frequency Hearing Loss	Hereditary Low-Frequency Sensorineural Hearing Loss
Lfsnhl1	Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 1
Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 1	Deafness, Autosomal Dominant, Type 1

Osteogenesis Imperfecta, Type Xv

Osteogenesis Imperfecta Type 15	OI15
Osteogenesis Imperfecta Type Xv	Oi, Type Xv
Osteogenesis Imperfecta 15	Oi Type Xv
Oi-Xv

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-113801	N-(3-Oxooctanoyl)-DL-homoserine lactone		99.15%	Unkown
HY-136345	(Rac)-3′-Hydroxy simvastatin		/	Unkown
HY-167811	1,2-Dipalmitoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] hydrochloride		/	Unkown
HY-RS11593	RAC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-100841	(Rac)-3-Hydroxyphenylglycine	Control	99.58%	Unkown
HY-W779204	rac-3-Hexadecanamido-2-methoxypropan-1-ol phosphocholine hydrate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAC3	VGNC	VGNC:76642
Bos taurus	RAC3	VGNC	VGNC:55865
Felis catus	RAC3	VGNC	VGNC:99429
Rattus norvegicus	RAC3	RGD	RGD:1590052
Mus musculus	RAC3	MGD	MGI:2180784

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