NRBP1 - nuclear receptor binding protein 1 Gene

Homo sapiens

Also known as MADM; NRBP; BCON3; MUDPNP

Gene ID: 29959 | Gene type: protein coding

About NRBP1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,427,790-27,442,259 (from NCBI)

This gene has 9 transcripts (splice variants), 272 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 41.1), testis (RPKM 38.5) and 25 other tissues.

Summary

Predicted to enable protein homodimerization activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]

NRBP1 Products(7)

mRNA	Protein	Name
NM_001321357.2	NP_001308286.1	nuclear receptor-binding protein isoform 1
NM_001321358.2	NP_001308287.1	nuclear receptor-binding protein isoform 2
NM_001321359.2	NP_001308288.1	nuclear receptor-binding protein isoform 2
NM_001321361.2	NP_001308290.1	nuclear receptor-binding protein isoform 3
NM_001321362.2	NP_001308291.1	nuclear receptor-binding protein isoform 4
NM_001321363.2	NP_001308292.1	nuclear receptor-binding protein isoform 5
NM_013392.4	NP_037524.1	nuclear receptor-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11956649	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	11956649	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endomembrane system	IDA IDA: Inferred from direct assay	11956649	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRBP1 Protein Structure

Pkinase

0
100
200
300
400
500
535 a.a.

Protein Preferred Names

Protein Names

nuclear receptor-binding protein

multiple domain putative nuclear protein

NRBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NRBP1	Q9UHY1	TSC22D4	Homo sapiens	Q8IV54	Y2H Prey Pooling	25416956
Intra	NRBP1	Q9UHY1	TSC22D4	Homo sapiens	Q8IV54	Validated Y2H	25416956
Intra	NRBP1	Q9UHY1	TSC22D4	Homo sapiens	Q8IV54	Y2H Array	25416956
Intra	NRBP1	Q9UHY1	C2orf50	Homo sapiens	Q96LR7	Y2H Prey Pooling	32296183
Intra	NRBP1	Q9UHY1	C2orf50	Homo sapiens	Q96LR7	Y2H Array	32296183
Intra	NRBP1	Q9UHY1	SNX31	Homo sapiens	Q8N9S9-2	Y2H Array	32296183
Intra	NRBP1	Q9UHY1	SNX31	Homo sapiens	Q8N9S9-2	Y2H Prey Pooling	32296183
Cross	NRBP1	Q9UHY1	Sall4	Mus musculus	Q8BX22	Anti Tag CoIP	22510880
Cross	NRBP1	Q9UHY1	Sall4	Mus musculus	Q8BX22	TAP	22510880
Intra	NRBP1	Q9UHY1	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Pooling	16189514
Intra	NRBP1	Q9UHY1	TSC22D4	Homo sapiens	Q9Y3Q8	MAPPIT	25416956
Intra	NRBP1	Q9UHY1	TSC22D4	Homo sapiens	Q9Y3Q8	Pull Down	32707033
Intra	NRBP1	Q9UHY1	TSC22D4	Homo sapiens	Q9Y3Q8	Anti Tag CoIP	35271311
Intra	NRBP1	Q9UHY1	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	NRBP1	Q9UHY1	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	NRBP1	Q9UHY1	RAC3	Homo sapiens	P60763	IF	11956649
Intra	NRBP1	Q9UHY1	RAC3	Homo sapiens	P60763	Y2H	11956649
Cross	NRBP1	Q9UHY1	polg_den2n	Dengue virus type 2	P14340	Anti Tag CoIP	15084397
Cross	NRBP1	Q9UHY1	polg_den2n	Dengue virus type 2	P14340	Y2H	15084397
Cross	NRBP1	Q9UHY1	polg_den2n	Dengue virus type 2	P14340	Imaging	15084397

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09562	NRBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NRBP1	MGD	MGI:2183436
Bos taurus	NRBP1	VGNC	VGNC:32255
Canis familiaris	NRBP1	VGNC	VGNC:43961
Rattus norvegicus	NRBP1	RGD	RGD:1589575
Felis catus	NRBP1	VGNC	VGNC:68561
Macaca mulatta	NRBP1	VGNC	VGNC:75524
Others	NRBP1	NCBI

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