2. Gene
  3. RPS6KA1 - ribosomal protein S6 kinase A1 Gene

RPS6KA1 - ribosomal protein S6 kinase A1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RSK; HU-1; RSK1; p90Rsk; MAPKAPK1; MAPKAPK1A

Gene ID: 6195 | Gene type: protein coding

About RPS6KA1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,529,761-26,575,025 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 218 orthologues and 7 paralogues. Broad expression in small intestine (RPKM 31.6), duodenum (RPKM 29.3) and 21 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RPS6KA1 Products(5)

mRNA Protein Name
XM_024448871.2 XP_024304639.1 ribosomal protein S6 kinase alpha-1 isoform X2
XM_047427258.1 XP_047283214.1 ribosomal protein S6 kinase alpha-1 isoform X1
NM_001330441.2 NP_001317370.1 ribosomal protein S6 kinase alpha-1 isoform c
NM_002953.4 NP_002944.2 ribosomal protein S6 kinase alpha-1 isoform a
NM_001006665.2 NP_001006666.1 ribosomal protein S6 kinase alpha-1 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
IDA: Inferred from direct assay
18402937 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19470470 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10679322 GOA
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: Inferred from direct assay
22797923 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
35772404 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
18402937 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11684016 GOA
involved in positive regulation of hepatic stellate cell activation IMP
IMP: Inferred from mutant phenotype
10679322 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22065586 GOA
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
35772404 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (62 - 319)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (343 - 383)

Pkinase

Pkinase: Protein kinase domain (418 - 675)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-1

90 kDa ribosomal protein S6 kinase 1

MAP kinase-activated protein kinase 1a

MAPK-activated protein kinase 1a

MAPKAP kinase 1a

MAPKAPK-1a

RSK-1

S6K-alpha 1

dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)

p90-RSK 1

p90RSK1

p90S6K

ribosomal S6 kinase 1

ribosomal protein S6 kinase, 90kDa, polypeptide 1

RPS6KA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RPS6KA1 Q15418 CDC37 Homo sapiens Q16543
Anti Tag CoIP
35271311
Intra RPS6KA1 Q15418 CDC37 Homo sapiens Q16543
Anti Tag CoIP
31980649
Intra RPS6KA1 Q15418 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra RPS6KA1 Q15418 HSP90AB1 Homo sapiens P08238
TAP
23455922
Intra RPS6KA1 Q15418 SCRIB Homo sapiens Q14160
Pull Down
30126976
Intra RPS6KA1 Q15418 S100B Homo sapiens P04271
FPS
31837246
Intra RPS6KA1 Q15418 VASP Homo sapiens P50552
Protein Kinase Assay
21423205
Intra RPS6KA1 Q15418 VASP Homo sapiens P50552
Anti Bait CoIP
21423205
Intra RPS6KA1 Q15418 MAPK1 Homo sapiens P28482
TAP
23455922
Intra RPS6KA1 Q15418 MAPK1 Homo sapiens P28482
X-Ray Diffraction
23519423
Cross RPS6KA1 Q15418 yopM Yersinia enterocolitica serotype O:8/biotype 1B A1JU68
Anti Bait CoIP
25513777
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease
Coffin-Lowry Syndrome

CLS

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Syndrome 1

Coffin Syndrome

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Coffin Lowry Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123919 TL13-112 Inhibitor 98.15% Unkown
HY-148063 DB0614 98.80% Unkown
HY-122582 TL13-12 Inhibitor 98.06% Unkown
HY-148061 DB1113 99.28% Unkown
HY-136194 TL13-22 Inhibitor 99.71% Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-RS12248 RPS6KA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12249 Rps6ka1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12250 Rps6ka1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RPS6KA1 VGNC VGNC:45738
Macaca mulatta RPS6KA1 VGNC VGNC:76927
Rattus norvegicus RPS6KA1 RGD RGD:620675
Felis catus RPS6KA1 VGNC VGNC:64754
Bos taurus RPS6KA1 VGNC VGNC:34140
Mus musculus RPS6KA1 MGD MGI:104558
Others RPS6KA1 NCBI