2. Gene
  3. VASP - vasodilator stimulated phosphoprotein Gene

VASP - vasodilator stimulated phosphoprotein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 7408 | Gene type: protein coding

About VASP

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,507,479-45,526,983 (from NCBI)

This gene has 13 transcripts (splice variants), 276 orthologues and 5 paralogues. Ubiquitous expression in appendix (RPKM 50.6), spleen (RPKM 48.4) and 25 other tissues.

Summary

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

VASP Products(1)

mRNA Protein Name
NM_003370.4 NP_003361.1 vasodilator-stimulated phosphoprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables profilin binding IPI
IPI: Inferred from physical interaction
17914456 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8836115 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
23153535 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VASP Protein Structure

WH1

WH1: WH1 domain (4 - 109)

VASP_tetra

VASP_tetra: VASP tetramerisation domain (341 - 379)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

vasodilator-stimulated phosphoprotein

VASP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VASP P50552 FAF2 Homo sapiens Q96CS3
Phage Display
35044719
Intra
VASP P50552 ABI1 Homo sapiens Q8IZP0-5
Y2H Array
32296183
Intra
VASP P50552 ABI1 Homo sapiens Q8IZP0-5
Y2H Prey Pooling
32296183
Intra
VASP P50552 ABI1 Homo sapiens Q8IZP0-5
Validated Y2H
32296183
Intra
VASP P50552 PSORS1C2 Homo sapiens Q9UIG4
Validated Y2H
32296183
Intra
VASP P50552 PSORS1C2 Homo sapiens Q9UIG4
Complementation
32296183
Intra
VASP P50552 CEP43 Homo sapiens O95684
Y2H Prey Pooling
25416956
Intra
VASP P50552 CEP43 Homo sapiens O95684
Anti Tag CoIP
33961781
Intra
VASP P50552 CEP43 Homo sapiens O95684
Validated Y2H
25416956
Cross
VASP P50552 ypkA Yersinia pestis Q9RI12
Y2H Array
21911467
Intra
VASP P50552 NSMAF Homo sapiens Q92636
Anti Bait CoIP
17599063
Intra
VASP P50552 HSPA8 Homo sapiens P11142
Crosslink
30021884
Intra
VASP P50552 HSPA8 Homo sapiens P11142
Anti Tag CoIP
33961781
Intra
VASP P50552 ZYX Homo sapiens Q15942
Anti Tag CoIP
33961781
Intra
VASP P50552 ZYX Homo sapiens Q15942
Y2H Prey Pooling
32296183
Intra
VASP P50552 ZYX Homo sapiens Q15942
Anti Tag CoIP
28514442
Intra
VASP P50552 ZYX Homo sapiens Q15942
Validated Y2H
32296183
Intra
VASP P50552 ZYX Homo sapiens Q15942
Y2H Array
32296183
Intra
VASP P50552 TRIM9 Homo sapiens Q9C026
Y2H Prey Pooling
32296183
Intra
VASP P50552 TRIM9 Homo sapiens Q9C026
Validated Y2H
32296183
Intra
VASP P50552 TRIM9 Homo sapiens Q9C026
Y2H Array
32296183
Intra
VASP P50552 TRIM9 Homo sapiens Q9C026
Y2H Pooling
16189514
Intra
VASP P50552 NR4A1 Homo sapiens P22736
Display Tech
20195357
Intra
VASP P50552 NR4A1 Homo sapiens P22736
TAP
20195357
Intra
VASP P50552 ABI3 Homo sapiens Q9P2A4
Y2H Prey Pooling
32296183
Intra
VASP P50552 ABI3 Homo sapiens Q9P2A4
Y2H Array
25416956
Intra
VASP P50552 ABI3 Homo sapiens Q9P2A4
Y2H Array
32296183
Intra
VASP P50552 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra
VASP P50552 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
Intra
VASP P50552 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra
VASP P50552 XIRP1 Homo sapiens Q702N8
Y2H
16631741
Intra
VASP P50552 XIRP1 Homo sapiens Q702N8
Filter Binding
16631741
Intra
VASP P50552 XIRP1 Homo sapiens Q702N8
Far-WB
16631741
Intra
VASP P50552 SCGB2A2 Homo sapiens Q13296
Validated Y2H
25416956
Intra
VASP P50552 SCGB2A2 Homo sapiens Q13296
Y2H Array
25416956
Intra
VASP P50552 RPS6KA1 Homo sapiens Q15418
Anti Bait CoIP
21423205
Cross
VASP P50552 VCL Gallus gallus P12003
Pull Down
8836115
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Thrombosis

Thrombosis Of Blood Vessel
Osteogenesis Imperfecta, Type Xvi

Osteogenesis Imperfecta Type 16

OI16

Oi, Type Xvi

Osteogenesis Imperfecta Type Xvi

Chromosome 11p11.2 Deletion Syndrome 91.3-Kb

Osteogenesis Imperfecta 16

Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb
Shigellosis

Dysentery, Bacillary

Bacillary Dysentery

Shigella Boydii Infectious Disease

Shigella Flexneri Infectious Disease

Shigella Gastroenteritis

Shigella Sonnei Infectious Disease

Shigella Infections
Febrile Seizures, Familial, 1

FEB1

Convulsions, Familial Febrile, 1

Familial Febrile Seizures 1

Familial Febrile Convulsions 1
Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10

OI10

Osteogenesis Imperfecta Type X

Oi, Type X

Osteogenesis Imperfecta 10

Oi Type X

Oi-X
Lissencephaly 4

LIS4

Lissencephaly 4 With Microcephaly

Microlissencephaly

Lissencephaly, Type 4
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153967 BLU0588 Inhibitor 95.92% Unkown
HY-155106 SMA4 / Unkown
HY-RS15609 VASP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VASP VGNC VGNC:36769
Macaca mulatta VASP VGNC VGNC:78756
Rattus norvegicus VASP RGD RGD:1311542
Mus musculus VASP MGD MGI:109268
Felis catus VASP VGNC VGNC:66922
Others VASP NCBI