VASP - vasodilator stimulated phosphoprotein Gene

Homo sapiens

Gene ID: 7408 | Gene type: protein coding

About VASP

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,507,479-45,526,983 (from NCBI)

This gene has 13 transcripts (splice variants), 276 orthologues and 5 paralogues. Ubiquitous expression in appendix (RPKM 50.6), spleen (RPKM 48.4) and 25 other tissues.

Summary

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

VASP Products(1)

mRNA	Protein	Name
NM_003370.4	NP_003361.1	vasodilator-stimulated phosphoprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables profilin binding	IPI IPI: Inferred from physical interaction	17914456	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8836115	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	23153535	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VASP Protein Structure

WH1

VASP_tetra

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

vasodilator-stimulated phosphoprotein

Related Diseases

Diseases

Alias

Thrombosis

Thrombosis Of Blood Vessel

Osteogenesis Imperfecta, Type Xvi

Osteogenesis Imperfecta Type 16	OI16
Oi, Type Xvi	Osteogenesis Imperfecta Type Xvi
Chromosome 11p11.2 Deletion Syndrome 91.3-Kb	Osteogenesis Imperfecta 16
Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb

Shigellosis

Dysentery, Bacillary	Bacillary Dysentery
Shigella Boydii Infectious Disease	Shigella Flexneri Infectious Disease
Shigella Gastroenteritis	Shigella Sonnei Infectious Disease
Shigella Infections

Febrile Seizures, Familial, 1

FEB1	Convulsions, Familial Febrile, 1
Familial Febrile Seizures 1	Familial Febrile Convulsions 1

Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10	OI10
Osteogenesis Imperfecta Type X	Oi, Type X
Osteogenesis Imperfecta 10	Oi Type X
Oi-X

Lissencephaly 4

LIS4	Lissencephaly 4 With Microcephaly
Microlissencephaly	Lissencephaly, Type 4

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153967	BLU0588	Inhibitor	95.92%	Unkown
HY-155106	SMA4		/	Unkown
HY-RS15609	VASP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VASP	VGNC	VGNC:36769
Macaca mulatta	VASP	VGNC	VGNC:78756
Rattus norvegicus	VASP	RGD	RGD:1311542
Mus musculus	VASP	MGD	MGI:109268
Felis catus	VASP	VGNC	VGNC:66922
Others	VASP	NCBI

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