2. Gene
  3. S100A2 - S100 calcium binding protein A2 Gene

S100A2 - S100 calcium binding protein A2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAN19; S100L

Gene ID: 6273 | Gene type: protein coding

About S100A2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,561,108-153,565,844 (from NCBI)

This gene has 6 transcripts (splice variants), 323 orthologues and 21 paralogues. Biased expression in esophagus (RPKM 199.3), urinary bladder (RPKM 56.6) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast Cancer. [provided by RefSeq, Jul 2008]

S100A2 Products(3)

mRNA Protein Name
NM_001366406.1 NP_001353335.1 protein S100-A2 isoform 2
NM_001366407.1 NP_001353336.1 protein S100-A2 isoform 3
NM_005978.4 NP_005969.2 protein S100-A2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20188096 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endothelial cell migration IMP
IMP: Inferred from mutant phenotype
15313892 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A2 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (5 - 47)

  • 0
  • 97 a.a.
Protein Preferred Names Protein Names

protein S100-A2

S100A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
S100A2 P29034 S100A3 Homo sapiens P33764
Validated Y2H
32296183
Intra
S100A2 P29034 S100A3 Homo sapiens P33764
Complementation
32296183
Intra
S100A2 P29034 S100A3 Homo sapiens P33764
MAPPIT
32296183
Intra
S100A2 P29034 EZR Homo sapiens P15311
FPS
31837246
Intra
S100A2 P29034 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
S100A2 P29034 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
S100A2 P29034 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
S100A2 P29034 TRPM4 Homo sapiens Q8TD43
FPS
31837246
Intra
S100A2 P29034 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
S100A2 P29034 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
S100A2 P29034 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
S100A2 P29034 KPNA2 Homo sapiens P52292
EMSA Supershift
20965181
Intra
S100A2 P29034 KPNA2 Homo sapiens P52292
Pull Down
20965181
Intra
S100A2 P29034 MYH9 Homo sapiens P35579
FPS
31837246
Intra
S100A2 P29034 TP53 Homo sapiens P04637
FPS
31837246
Intra
S100A2 P29034 TP53 Homo sapiens P04637
GMS
20591429
Intra
S100A2 P29034 MDM2 Homo sapiens Q00987
SPR
20591429
Intra
S100A2 P29034 MDM4 Homo sapiens O15151
FPS
31837246
Intra
S100A2 P29034 S100B Homo sapiens P04271
Validated Y2H
25416956
Intra
S100A2 P29034 S100A1 Homo sapiens P23297
Y2H Array
25416956
Intra
S100A2 P29034 S100A1 Homo sapiens P23297
Y2H Prey Pooling
25416956
Intra
S100A2 P29034 S100A2 Homo sapiens P29034
Validated Y2H
32296183
Intra
S100A2 P29034 S100A2 Homo sapiens P29034
Y2H Prey Pooling
32296183
Intra
S100A2 P29034 S100A2 Homo sapiens P29034
Y2H Array
25416956
Intra
S100A2 P29034 S100A2 Homo sapiens P29034
Y2H Array
32296183
Intra
S100A2 P29034 S100A2 Homo sapiens P29034
X-Ray Diffraction
22394450
Intra
S100A2 P29034 S100A2 Homo sapiens P29034
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A2 Proteins

Cat. No. Product Name Accession Purity
HY-P72481 S100A2 Protein, Human P29034 (M1-P98) ≥95%
HY-P74585 S100A2 Protein, Human (HEK293, hFc) NP_005969.1 (M2-P98) ≥95%

Related Diseases

Diseases Alias
Epidermoid Cysts

Epidermoid Cyst

Sebaceous Cyst

Epidermal Inclusion Cyst

Epidermal Cyst
Pilomatrixoma

Pilomatricoma

PTR

Epithelioma Calcificans Of Malherbe

Benign Pilomatricoma

Calcifying Epithelioma Of Malherbe

Pilomatricoma, Somatic

Benign Pilomatrixoma

Malherbe Calcifying Epithelioma
Conjunctival Intraepithelial Neoplasm

Intraepithelial Neoplasia Of Conjunctiva

Conjunctival Intraepithelial Neoplasia
Chondroblastoma

Chondroblastoma Of Bone
Epidermal Appendage Tumor

Neoplasm Of Skin With Adnexal Differentiation

Neoplasm Of The Skin Appendage

Skin Appendage Tumour
Trachea Leiomyoma

Tracheal Neoplasms

Leiomyoma Of The Trachea

Tracheal Neoplasm

Tracheal Leiomyoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Conjunctival Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Conjunctiva

Conjunctival Epidermoid Carcinoma

Invasive Squamous Cell Carcinoma Of The Conjunctiva

Ocular Surface Squamous Neoplasia
Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Osteogenesis Imperfecta, Type Iv

Osteogenesis Imperfecta Type 4

Osteogenesis Imperfecta Type Iv

OI4

Oi, Type Iv

Osteogenesis Imperfecta With Normal Sclerae

Oi Type Iv

Oi Type 4

Osteogenesis Imperfecta With Normal Sclera

Common Variable Oi With Normal Sclerae

Osteogenesis Imperfecta 4

Oi-Iv
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145900 S100A2-p53-IN-1 Inhibitor / Unkown
HY-RS12378 S100A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus S100A2 MGD MGI:3510999
Canis familiaris S100A2 VGNC VGNC:45828
Bos taurus S100A2 VGNC VGNC:34242
Rattus norvegicus S100A2 RGD RGD:6500254
Macaca mulatta S100A2 VGNC VGNC:76956
Others S100A2 NCBI