DLG2 - Dlg2 discs large MAGUK scaffold protein 2 Gene

Rattus norvegicus

Also known as Dlgh2

Gene ID: 64053 | Gene type: protein coding

About DLG2

Summary

Enables PDZ domain binding activity; protein C-terminus binding activity; and protein Phosphatase binding activity. Involved in neuronal ion channel clustering and receptor clustering. Located in several cellular components, including dendrite; juxtaparanode region of axon; and neuronal cell body. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

DLG2 Products(1)

mRNA	Protein	Name
NM_022282.2	NP_071618.2	disks large homolog 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15024025	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9786987	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	20410104	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	8755482	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuronal ion channel clustering	IMP IMP: Inferred from mutant phenotype	8755482	RGD
involved in receptor clustering	IMP IMP: Inferred from mutant phenotype	8755482	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	8755482	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10648730	RGD
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	19109503	RGD
located in membrane	IDA IDA: Inferred from direct assay	20089912	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8755482	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	10648730	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	20089912	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disks large homolog 2

channel-associated protein of synapse-110	chapsyn-110
discs, large homolog 2	disks large 1 tumor suppressor protein-like
postsynaptic density protein PSD-93	synaptic density protein PSD-93

DLG2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Dlg2	Q63622	ATP2B4	Homo sapiens	P23634-6	Anti Bait CoIP	11274188
Cross	Dlg2	Q63622	CRHR1	Homo sapiens	P34998	Anti Tag CoIP	26352593
Cross	Dlg2	Q63622	KIF1B	Homo sapiens	O60333-3	Y2H	12097473
Intra	Dlg2	Q63622	Map1a	Rattus norvegicus	P34926	Pull Down	9786987
Intra	Dlg2	Q63622	Map1a	Rattus norvegicus	P34926	Far-WB	9786987
Intra	Dlg2	Q63622	Dgkz	Rattus norvegicus	O08560	Y2H	19229292
Intra	Dlg2	Q63622	Dgkz	Rattus norvegicus	O08560	Anti Bait CoIP	19229292

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03797	DLG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	DLG2	NCBI	NCBI:1740

Name
Email *

	Sorry, but the email address you supplied was invalid.