BLMH - bleomycin hydrolase Gene

Homo sapiens

Also known as BH; BMH

Gene ID: 642 | Gene type: protein coding

About BLMH

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,248,203-30,291,944 (from NCBI)

This gene has 13 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in skin (RPKM 54.6), placenta (RPKM 12.9) and 25 other tissues.

Summary

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the Enzyme is metabolic inactivation of the Glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for Cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]

BLMH Products(1)

mRNA	Protein	Name
NM_000386.4	NP_000377.1	bleomycin hydrolase

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	EXP EXP: Inferred from Experiment	9668046	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11350084	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	31875550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLMH Protein Structure

Peptidase_C1_2

0
100
200
300
400
455 a.a.

Protein Preferred Names

Protein Names

bleomycin hydrolase

BLM hydrolase

BLMH Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BLMH	Q13867	NUDT12	Homo sapiens	Q9BQG2	Anti Tag CoIP	28514442
Intra	BLMH	Q13867	NUDT12	Homo sapiens	Q9BQG2	Validated Y2H	25910212
Intra	BLMH	Q13867	NUDT12	Homo sapiens	Q9BQG2	Y2H Bait-Prey Pool	25910212
Intra	BLMH	Q13867	NUDT12	Homo sapiens	Q9BQG2	Y2H Array	25910212
Intra	BLMH	Q13867	NUDT12	Homo sapiens	Q9BQG2	Y2H Prey Pooling	25416956
Intra	BLMH	Q13867	NUDT12	Homo sapiens	Q9BQG2	Anti Tag CoIP	33961781
Intra	BLMH	Q13867	TNPO3	Homo sapiens	Q9Y5L0	Validated Y2H	32296183
Intra	BLMH	Q13867	PGLS	Homo sapiens	O95336	Y2H Prey Pooling	32296183
Intra	BLMH	Q13867	TRIM47	Homo sapiens	Q96LD4-2	Validated Y2H	32296183
Intra	BLMH	Q13867	APP	Homo sapiens	P05067-4	Y2H	11350084
Intra	BLMH	Q13867	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	BLMH	Q13867	BLMH	Homo sapiens	Q13867	Y2H Prey Pooling	32296183
Intra	BLMH	Q13867	BLMH	Homo sapiens	Q13867	Validated Y2H	32296183
Intra	BLMH	Q13867	BLMH	Homo sapiens	Q13867	Y2H Array	32296183
Intra	BLMH	Q13867	BLMH	Homo sapiens	Q13867	Y2H Array	25416956
Intra	BLMH	Q13867	BLMH	Homo sapiens	Q13867	Y2H Pooling	16189514
Intra	BLMH	Q13867	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	BLMH	Q13867	BLMH	Homo sapiens	Q13867	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis	Testicular Germ Cell Tumor
Testicular Germ Cell Neoplasm	Testicular Malignant Germ Cell Tumor

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01521	BLMH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BLMH	VGNC	VGNC:26505
Macaca mulatta	BLMH	VGNC	VGNC:70255
Mus musculus	BLMH	MGD	MGI:1345186
Felis catus	BLMH	VGNC	VGNC:60123
Canis familiaris	BLMH	VGNC	VGNC:38465
Rattus norvegicus	BLMH	RGD	RGD:1304668
Others	BLMH	NCBI

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