Cdc42 - cell division cycle 42 Gene

Rattus norvegicus

Gene ID: 64465 | Gene type: protein coding

About Cdc42

Summary

Enables GTP binding activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including Cdc42 protein signal transduction; actin filament branching; and regulation of synapse organization. Located in Golgi membrane; plasma membrane; and secretory granule. Is active in Schaffer collateral - CA1 synapse. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]

Cdc42 Products(1)

mRNA	Protein	Name
NM_171994.5	NP_741991.3	cell division control protein 42 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	17161586	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	17161586	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15537656	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	20525016	RGD
involved in actin filament branching	IMP IMP: Inferred from mutant phenotype	17855387	RGD
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	21763307	RGD
involved in establishment of Golgi localization	IMP IMP: Inferred from mutant phenotype	20525016	RGD
involved in organelle transport along microtubule	IMP IMP: Inferred from mutant phenotype	20525016	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	9487126	RGD
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17161586	RGD
involved in positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	18562481	RGD
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	21844200	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17161586	RGD
involved in positive regulation of synapse structural plasticity	IMP IMP: Inferred from mutant phenotype	21423166	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	21423166	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	21423166	RGD
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	18562481	RGD
involved in submandibular salivary gland formation	IEP IEP: Inferred from expression pattern	18784978	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	15147909	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	21423166	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	21423166	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15537656	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15537656	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cell division control protein 42 homolog

cell division cycle 42 (GTP binding protein)

cell division cycle 42 homolog

Cdc42 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Cdc42	Q8CFN2	BAIAP2	Homo sapiens	Q9UQB8	Y2H	18448434

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-I0400	N-Acetylneuraminic acid		99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12646	Rhosin hydrochloride		99.93%	Unkown
HY-12755	ML141		99.87%	Unkown
HY-12874	CASIN		99.89%	Unkown
HY-112842	MBQ-167	Inhibitor	99.86%	Unkown
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-111424	BDP9066	Inhibitor	98.36%	Unkown
HY-13963	ZCL278	Inhibitor	98.46%	Unkown
HY-N0710	alpha-Cyperone		99.80%	Unkown
HY-136379	CID44216842	Inhibitor	99.84%	Unkown
HY-B0580B	(R)-Ketorolac	Inhibitor	99.65%	Unkown
HY-136383	AZA1		98.07%	Unkown
HY-115376	Z62954982	Inhibitor	≥99.0%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-113849	MLS-573151	Inhibitor	99.74%	Unkown
HY-149464	ARN22089	Inhibitor	98.73%	Unkown
HY-111424A	(R)-BDP9066	Inhibitor	98.49%	Unkown
HY-15031	l-Naproxen	Inhibitor	99.63%	Unkown
HY-116269	AZA197		98.28%	Unkown
HY-152095	PPI-GIT1/β-Pix interaction-IN-1	Inhibitor	99.01%	Unkown
HY-RS02300	CDC42 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-111423	BDP8900	Inhibitor	/	Unkown
HY-149921	Antiangiogenic agent 3	Inhibitor	/	Unkown
HY-161736	ARN25499	Inhibitor	/	Unkown
HY-170327	ZCL279	Inhibitor	/	Unkown
HY-RS02301	CDC42BPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02303	CDC42EP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02304	CDC42EP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02305	CDC42EP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-12646A	Rhosin		/	Unkown
HY-167828	ARN25062	Inhibitor	/	Unkown
HY-D2415	BODIPY-FL staurosporine		/	Unkown
HY-N15267	Ovalitenone	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdc42	NCBI	NCBI:998

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